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Pocket Guide to GastrointestinaI Drugs

  • ID: 2638455
  • Book
  • 288 Pages
  • John Wiley and Sons Ltd
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Learn all you need to know about gastrointestinal drugs and their clinical use with this one–stop, rapid reference pocket guide.

Brought to you by many of the world′s leading GI drug experts, Pocket Guide to Gastrointestinal Drugs provides comprehensive guidance to the pharmacological properties of drugs used to treat gastrointestinal conditions, including mechanisms of action, appropriate administration, and potential adverse effects associated with their use.

Organized by class of drug and ranging from PPIs to immunosupressants, each chapter first examines the specific agents within that class and then their appropriate and judicious use across a range of specific GI disorders.

Key features include:

  • Introduction of drug class
  • Basic pharmacology, including mechanism of action, bioavailability, metabolism, interactions, adverse effects, toxicity, and special considerations
  • Dosing information for each GI condition and on– and off–label use
  • Consistent use of both generic and trade names throughout
  • Specific reference to drug use in pediatric patients and during pregnancy

Perfect for quick consultation on the wards and in the office, Pocket Guide to Gastrointestinal Drugs is the ideal tool for all those managing patients with GI conditions, including gastroenterologists, GI trainees, emergency physicians, GI specialist nurses, primary care physicians and residents, intensivists and pharmacists.

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List of contributors, xi

Preface, xvi


1 Prokinetic agents and antiemetics, 3Hemangi Kale and Ronnie Fass

Prokinetics, 3

Antiemetic agents, 7

Recommended reading, 14

2 Proton pump inhibitors, 15Wanda P. Blanton and M. Michael Wolfe

Introduction, 15

Mechanism of action, pharmacodynamics, kinetics, 15

Clinical use and dosing, 18

Adverse effects/safety, 27

Recommended reading, 28

3 Histamine H2–receptor antagonists, 31Kentaro Sugano

Introduction, 31

Mechanism of action, 31

Pharmacology, 33

Clinical effectiveness, 40

Adverse events, 41

Recommended reading, 42

4 Prostaglandins and other mucosal protecting agents, 44Carlos Sostres and Angel Lanas

Introduction of drug class, 44

Physicochemical properties, 45

Formulations and recommended dosages, 46

Mechanism of action, 47

Drug interactions, 48

Pharmacokinetics, 49

Clinical effectiveness, 49

Toxicity, 51

Pregnancy classes, 52

Other mucosal protecting agents, 52

Recommended reading, 54


5 5–HT modulators and other antidiarrheal agents and cathartics, 59Albena Halpert and Douglas Drossman

Introduction, 59

5–HT modulators used in the management of GI disorders, 59

5–HT agents approved in the US for specific GI indications, 60

Medications used for the treatment of chronic constipation, 71

Medications used for the treatment of narcotic–induced constipation, 76

Antidiarrheal agents, 76

Conclusion, 80

Recommended reading, 80

6 5–aminosalicylates, 82Hannah L. Miller and Francis A. Farraye

Introduction, 82

Preparations, 82

Clinical use and efficacy, 84

Pharmacology: preparations and dosing, 87

Mechanism of action, 89

Bioavailability and metabolism, 89

Adverse effects and toxicity, 91

Pregnancy, 93

Drug interactions (package inserts), 94

Precautions and contraindications, 94

Special considerations: effectiveness in colorectal cancer prevention, 96

Conclusion, 97

Recommended reading, 97

7 Immunosuppressive agents, 100Lev Lichtenstein and Gerald M. Fraser

Introduction, 100

Thiopurines, 100

Low–dose methotrexate (MTX), 106

Calcineurin inhibitors, 111

Recommended reading, 114

8 Biological agents, 117Gert Van Assche

Biological agents approved to treat IBD, 117

Optimal treatment strategies with anti TNF therapies in IBD, 119

Safety of biological agents in IBD, 120

Emerging biologicals, 121

Recommended reading, 121


9 Interferons, 125Robert C. Lowe

Introduction, 125

Mechanism of action, 125

Pharmacology, 126

Clinical effectiveness, 127

Toxicity, 128

Interferon types with generic and brand names, 129

Pregnancy classes, 130

Initial interferon dosing regimens for chronic hepatitis C, 130

Recommended reading, 131

10 Nucleoside analogs, 133Uri Avissar and David P. Nunes

Introduction, 133

Mechanism of action, 135

Pharmacology, 137

Clinical effectiveness, 139

Nucleoside analogs, 141

Nucleotide analogs, 146

Summary, 147

Recommended reading, 148

11 Ursodeoxycholic acid, chelating agents, and zinc in the treatment of metabolic liver diseases, 150Andrew K. Burroughs and James S. Dooley

Ursodeoxycholic acid, 150

Treatment of copper overload, 155

Recommended reading, 162

12 Agents for the treatment of portal hypertension, 165Karen L. Krok and Andrés Cárdenas

Introduction, 165

Nonselective beta–blockers (NSBB), 166

Nitrates, 169

Vasopressin analogs, 169

Somatostatin analog, 170

Midodrine, 171

Albumin, 172

Loop diuretics, 172

Aldosterone antagonist, 174

Aquaretics, 174

Disaccharides, 175

Antibiotics, 176

Recommended reading, 177

13 Pancreatic enzymes, 179Steven J. Czinn and Samra S. Blanchard

Introduction, 179

Mechanism of action, 180

Dosing and schedule of administration, 180

Monitoring therapy, 183

Adverse effects, 183

Recommended reading, 184


14 Antibiotics for the therapy of gastrointestinal diseases, 187Melissa Osborn

Introduction, 187

Pharmacologic properties, 187

Clinical uses, 195

Recommended reading, 202

15 Antimicrobials for parasitic diseases, 204Joachim Richter

5–Nitroimidazoles, 204

Benzimidazoles, 206

Ivermectin, 211

Praziquantel, 212

Treatment dosages, 214

Recommended reading, 216

16 Vaccines for viral hepatitides, 219Savio John and Raymond T. Chung

Hepatitis A vaccination, 219

Hepatitis B vaccination, 222

Recommended reading, 227

17 Rotavirus and other enteric vaccinations, 229Christopher J. Moran and Esther J. Israel

Rotavirus vaccination, 229

Typhoid fever vaccination, 232

Recommended reading, 233


18 Parenteral and enteral nutrition feeding formulas, 237Dominic N. Reeds and Beth Taylor

Introduction, 237

Indications for nutrition support, 237

Energy and macronutrient requirements, 237

Protein, 238

Carbohydrate, 239

Lipids, 239

Enteral liquid feeding formulations, 239

Disease–specifi c formulas, 244

Selection of an appropriate enteral formula, 245

Implementation of enteral nutrition, 245

Parenteral nutrition, 245

Summary, 247

Recommended reading, 247

19 Probiotics, 249Christina M. Surawicz

Introduction, 249

Pharmacology, 250

Mechanisms of action, 251

Clinical indications, 251

Safety/toxicity, 255

Summary, 255

Recommended reading, 256

Index, 259

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M. Michael Wolfe
Robert C. Lowe
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