- Contributions from leading authorities- Informs and updates on all the latest developments in the field
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- Regulation of Immunoglobulin Class Switch Recombination: Choreography of Non-Coding Transcription, Targeted DNA Deamination and Long-Range DNA Repair
Allysia Matthews, Simin Zheng, Lauren DiMenna and Jayanta Chaudhuri
- Two Forms of Adaptive Immunity in Vertebrates: Similarities and Differences
Masanori Kasahara and Yoichi Sutoh
- Recognition of Tumors by the Innate Immune System and Natural Killer Cells
Assaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin and David H. Raulet
- Signaling Circuits in Early B Cell Development
Michael Reth and Peter Nielsen
- Interleukin 10 Receptor Signaling: Master Regulator of Intestinal Mucosal Homeostasis in Mice and Humans
Dror S. Shouval, Jodie Ouahed, Amlan Biswas, Jeremy A. Goettel, Bruce Horwitz, Alexio M. Muise and Scott B. Snapper
- Development of Mast Cells and Importance of their Tryptase and Chymase Serine Proteases in Inflammation and Wound Healing
Jeffrey Douaiher, Julien Succar, Luca Lancerotto, Michael F. Gurish, Dennis P. Orgill, Matthew J. Hamilton, Steven A. Krilis and Richard L. Stevens
- Why does Somatic Hypermutation by AID Require Transcription of its Target Genes?
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.