Cancer Gene Therapy by Viral and Non–viral Vectors. Translational Oncology - Product Image

Cancer Gene Therapy by Viral and Non–viral Vectors. Translational Oncology

  • ID: 2766405
  • Book
  • 176 Pages
  • John Wiley and Sons Ltd
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Provides expert, state–of–the–art insight into the current progress of viral and non–viral gene therapy

Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one–size–fits–all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor.
This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene–based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non–viral Vectors deals with the practice of gene–therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non–viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy.
Presented in three parts, Cancer Gene Therapy by Viral and Non–viral Vectors covers:

Delivery Systems

 Translational Cancer Research: Gene Therapy by Viral and Non–viral Vectors

 Retroviruses for Cancer Therapy

 DNA Plasmids for Non–viral Gene Therapy of Cancer

 Cancer Therapy with RNAi delivered by Non–viral Membrane/Core Nanoparticles

Targeted Expression

 Cancer Gene Therapy by Tissue–specific and Cancer–targeting Promptors

 MicroRNAs as Drugs and Drug Targets in Cancer

Principles of Clinical Trials in Gene Therapy

 Regulatory issues for Manufacturers of Viral Vectors and Vector–transduced Cells for Phase I/II Trials

 US Regulations Governing Clinical Trials in Gene Therapy

 Remaining Obstacles to the Success of Cancer Gene Therapy

Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non–viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.

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List of Contributors, vii

Series Foreword, ix

Preface, xi

Part I Delivery Systems

1 Translational Cancer Research: Gene Therapy by Viral and Non–viral Vectors, 3Vincenzo Cerullo, Kilian Guse, Markus Vähä–Koskela, and Akseli Hemminki

2 Retroviruses for Cancer Therapy, 21Jiehua Zhou, Yue Ding, John C. Burnett, and John Rossi

3 DNA Plasmids for Non–viral Gene Therapy of Cancer, 39Amer M. Najjar, Judy S.E. Moyes, and Laurence J.N. Cooper

4 Cancer Therapy with RNAi Delivered by Non–viral Membrane/Core Nanoparticles, 61Andrew B. Satterlee and Leaf Huang

Part II Targeted Expression

5 Cancer Gene Therapy by Tissue–specific and Cancer–targeting Promoters, 81Jennifer L. Hsu, Longfei Huo, Chia–Wei Li, Yi–Hsin Hsu, Yan Wang, and Mien–Chie Hung

6 MicroRNAs as Drugs and Drug Targets in Cancer, 97Hui Ling and George A. Calin

Part III Principles of Clinical Trials in Gene Therapy

7 Regulatory Issues for Manufacturers of Viral Vectors and Vector–transduced Cells for Phase I/II Trials, 115Adrian P. Gee and Zhuyong Mei

8 US Regulations Governing Clinical Trials in Gene Therapy, 131Bambi Grilley

9 Remaining Obstacles to the Success of Cancer Gene Therapy, 151Malcolm K. Brenner

Index, 157

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Edited by
Malcolm K. Brenner, MB, BChir, PhD, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA

Mien–Chie Hung PhD, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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