An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced.
All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography).
Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results.
- The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches
- 80% updated and new content
- New Chapter on "Biophysics of Voltage-Gated Ion Channels"
- New Chapter on "Synaptic Plasticity"
- Includes a chapter on the Neurobiology of Disease
- Highly referenced, comprehensive and quantitative
- Full color, professional graphics throughout
- All graphics are available in electronic version for teaching purposes
SECTION I. CELLULAR AND MOLECULAR 1. Cellular Components of Nervous Tissue
Patrick R. Hof, Graham Kidd, Javier DeFelipe, Jean de Vellis, Miguel A. Gama Sosa, Gregory A. Elder and Bruce D. Trapp 2. Subcellular Organization of the Nervous System: Organelles and Their Functions
Scott Brady and Peter Brophy 3. Energy Metabolism in the Brain
Gerald Dienel 4. Intracellular Signaling
Howard Schulman 5. Regulation of Neuronal Gene Expression and Protein Synthesis
Cristina Alberini and Eric Klann 6. Modeling and Analysis of Intracellular Signaling Pathways
Paul D. Smolen, Douglas A. Baxter and John H. Byrne 7. Pharmacology and Biochemistry of Synaptic Transmission: Classical Transmitters
Ariel Y. Deutch and Robert H. Roth 8. Nonclassic Signaling in the Brain
Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts 9. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More
Juan C. Sáez and Bruce Nicholson 10. Neurotransmitter Receptors
M. Neal Waxham 11. Molecular Properties of Ion Channels
Jason Tien, Yuh Nung Jan and Lily Yeh Jan
SECTION II. PHYSIOLOGY OF ION CHANNELS, EXCITABLE MEMBRANES AND SYNAPTIC TRANSMISSION 12. Membrane Potential and Action Potential
David A. McCormick 13. Biophysics of Voltage-Gated Ion Channels
Diane Lipscombe 14. Dynamical Properties of Excitable Membranes
Douglas A. Baxter and John H. Byrne 15. Release of Neurotransmitters
Robert S. Zucker, Dimitri M. Kullmann and Pascal S. Kaeser 16. Postsynaptic Potentials and Synaptic Integration
John H. Byrne 17. Cable Properties and Information Processing in Dendrites
SECTION III. INTEGRATION 18. Synaptic Plasticity
Ruth Heidelberger, Harel Shouval, Robert S. Zucker and John H. Byrne 19. Information Processing in Neural Networks
James J. Knierim 20. Learning and Memory: Basic Mechanisms
John H. Byrne, Kevin S. LeBar, Joseph LeDoux, Glenn E. Schafe and Richard F. Thompson 21. Molecular Mechanisms of Neurological Disease
Monica Gireud, Natalie Sirisaengtaksin and Andrew J. Bean
The June and Virgil Waggoner Professor and Chair, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Byrne is an internationally acclaimed Neuroscientist. He received his PhD under the direction of Noble Prize winner, Eric Kandel. Dr. Byrne is a prolific author and Editor-in-Chief of Learning and Memory (CSHP).
Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Heidelberger is an accomplished cellular neurophysiologist specializing in mechanisms of neurotransmitter release. She received her doctoral training under the guidance of Gary Matthews and her postdoctoral training under the direction of Nobel Laureate Erwin Neher. Dr. Heidelberger is a former president and executive board member of the Biophysical Society's Subgroup on Exocytosis and Endocytosis and serves on the editorial board of the Journal of Neurophysiology. She has directed and taught graduate-level courses in cellular neurophysiology and membrane biophysics for more than a decade.
Waxham, M. Neal
The William Wheless III Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Waxham's multi-disciplinary laboratory focuses on the molecular and cellular mechanisms of synaptic function and plasticity. He has developed and directed graduate-level courses in cellular and molecular neurobiology for more than two decades.