Biochemical Engineering. A Textbook for Engineers, Chemists and Biologists. 2nd, Completely Revised and Enlarged Edition

  • ID: 2882982
  • Book
  • 328 Pages
  • John Wiley and Sons Ltd
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Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co–author Jun–ichi Horiuchi, who is one of the leading experts in the field.

The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self–study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions.

An excellent, comprehensive introduction to the principles of biochemical engineering.
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Preface

Nomenclature

PART I: Basic Concepts and Principles

INTRODUCTION

Background and Scope

Dimensions and Units

Intensive and Extensive Properties

Equilibria and Rates

Batch vs. Continuous Operation

Material Balance

Energy Balance

ELEMENTA OF PHYSICAL TRANSFER PROCESSES

Introduction

Heat Conduction and Molecular Diffusion

Fluid Flow and Momentum Transfer

Laminar vs. Turbulent Flow

Transfer Phenomena in Turbulent Flow

Film Coefficients of Heat and Mass Transfer

CHEMICAL AND BIOCHEMICAL KINETICS

Introduction

Fundamental Reaction Kinetics

CELL KINETICS

Introduction

Cell Growth

Growth Phases in Batch Culture

Factors Affecting Rates of Cell Growth

Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF)

PART II: Unit Operations and Apparatus for Bio–Systems

HEAT TRANSFER

Introduction

Overall Coefficients U and Film Coefficients h

Mean Temperature Difference

Estimation of Film Coefficients h

Estimation of Overall Coefficients U

MASS TRANSFER

Introduction

Overall Coefficients K and Film Coefficients k of Mass Transfer

Types of Mass Transfer Equipment

Models for Mass Transfer at the Interface

Liquid Phase Mass Transfer with Chemical Reactions

Correlations for Film Coefficients of Mass Transfer

Performance of Packed Column

BIOREACTORS

Introduction

Some Fundamental Concepts

Bubbling Gas–Liquid Reactors

Mechanically Stirred Tanks

Gas Dispersion in Stirred Tanks

Bubble Columns

Airlift Reactors

Packed–Bed Reactors

Microreactors

MEMBRANE PROCESSES

Introduction

Dialysis

Ultrafiltration

Microfiltration

Reverse Osmosis

Membrane Modules

CELL–LIQUID SEPARATION AND CELL DISRUPTION

Introduction

Conventional Filtration

Microfiltration

Centrifugation

Cell Disruption

STERILIZATION

Introduction

Kinetics of Thermal Death of Cells

Batch Heat Sterilization of Culture Media

Continuous Heat Sterilization of Culture Media

Sterilizing Filtration

ADSORPTION AND CHROMATOGRAPHY

Introduction

Equilibria in Adsorption

Rates of Adsorption into Adsorbent Particles

Single– and Multi–Stage Processes for Adsorption

Adsorption in Fixed Beds

Separation by Chromatography

Biorecognition Assay

PART III: Practical Aspects in Bioengineering

FERMENTOR ENGINEERING

Introduction

Stirrer Power Requirements for Non–Newtonian Liquids

Heat Transfer in Fermentors

Gas–Liquid Mass Transfer in Fermentors

Criteria for Scaling–Up Fermentors

Modes of Fermentor Operation

Fermentors for Animal Cell Culture

INSTRUMENTATION AND CONTROL OF BIOPROCESSES

Introduction

Instrumentation of Bioprocesses

Control of Bioprocesses

Advanced Control of Bioprocesses

DOWNSTREAM OPERATIONS IN BIOPROCESSES

Introduction

Separation of Microorganisms by Filtration and Microfiltration

Separation by Chromatography

Separation in Fixed Beds

Sanitation in Downstream Processes

MEDICAL DEVICES

Introduction

Blood and Its Circulation

Oxygenation of Blood

Artificial Kidney

Bioartificial Liver

Appendix

Index

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Shigeo Katoh
Jun–ichi Horiuchi
Fumitake Yoshida
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