Chesley's Hypertensive Disorders in Pregnancy continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this the hypertensive disorders remain marginally studied and management is often controversial. The fourth edition of Chesley's Hypertensive Disorders in Pregnancy focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, and not just preeclampsia.
- Features new chapters focusing on recent discoveries in areas such as fetal programming, genomics/proteomics, and angiogenesis
- Includes extensive updates to chapters on epidemiology, etiological considerations, pathophysiology, prediction, prevention, and management
- Discusses the emerging roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia
- Each section overseen by one of the editors; each chapter co-authored by one of the editors, ensuring coherence throughout book
2. The Clinical Spectrum of Preeclampsia
3. Epidemiology of Pregnancy-Related Hypertension
4. Genetic Factors in the Etiology of Preeclampsia
5. The Placenta in Normal Pregnancy and Preeclampsia
6. Angiogenesis and Preeclampsia
7. Metabolic Syndrome and Preeclampsia
8. Immunology of Normal Pregnancy and Preeclampsia
9. Endothelial Cell Dysfunction and Oxidative Stress
10. Animal Models
11. Tests to Predict Preeclampsia
12. Prevention of Preeclampsia and Eclampsia
13. Cerebrovascular (Patho)Physiology in Preeclampsia/ Eclampsia
14. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy
15. The Renin-Angiotensin Systems, their Autoantibodies, and Body Fluid Volume in Preeclampsia
16. The Kidney and Normal Pregnancy and Preeclampsia
17. Platelets, Coagulation, and the Liver
18. Chronic Hypertension and Pregnancy
19. Antihypertensive Treatment
Robert N. Taylor, MD, PhD is Vice Chair for Research in the Department of Obstetrics and Gynecology at Wake Forest School of Medicine. Previously, he was Professor of Obstetrics and Gynecology at Emory University and Director of the Center for Reproductive Sciences at the University of California, San Francisco (UCSF). Dr. Taylor received his undergraduate education at Stanford University and completed the combined MD-PhD program at Baylor College of Medicine. His graduate work on the molecular biology of estrogen action was performed under the supervision of Roy G. Smith, PhD and Bert W. O'Malley, MD. Dr. Taylor trained as a resident in Obstetrics and Gynecology and subsequently as a fellow in Reproductive at UCSF. He then completed a postdoctoral fellowship with Lewis T. ("Rusty) Williams, MD, PhD in the Howard Hughes Medical Institute at UCSF, where he studied the regulation of placental angiogenesis by growth factors and their receptors. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist widely published in the areas of preeclampsia, embryonic implantation and endometriosis. Dr. Taylor serves on influential international, national and state executive committees including the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, several NIH Women's Reproductive Health Research advisory boards, and the California Institute for Regenerative Medicine. He is a Past President of the Society for Gynecologic Investigation and honorary secretary of the World Endometriosis Society.
Roberts, James M.
Dr. James M. Roberts, MD is Professor of Obstetrics and Gynecology and Epidemiology and Clinical and Translational Research at the University of Pittsburgh. His research includes fundamental, clinical and health services approaches to the understanding and management of adverse pregnancy outcomes. He led an NIH RCT (10,000 women) of antioxidant vitamins to prevent preeclampsia. He has been the recipient of lifetime achievement awards by the International Society for the Study of Hypertension in Pregnancy, the SGI and the Preeclampsia Foundation Hope. He has served or serves on the editorial boards of journals including, Placenta, Journal of Clinical Endocrinology, Metabolism. Reproductive Sciences, Women's Health Issues and Hypertension. He has been on scientific review boards of the NIH, the CIHR, the FDA and the March of Dimes. He was the chair of the NICHD Maternal Fetal Medicine Network from 1990 -1999 and is past president of the Perinatal Research Society, the North American Society for the Study of Hypertension in Pregnancy, the Society of Gynecological Investigation, and the International Society for the Study of Hypertension in Pregnancy. He was formally admitted to fellowship ad eundem of the Royal College of Obstetricians and Gynaecologists in September 2000. He has been elected to membership in the Institute of Medicine of the National Academy of Sciences. He has also received mentoring awards from the NICHD and the Society of Gynecological Investigation.
Cunningham, Gary F.
F. Gary Cunningham, MD is holder of the Miguel and Beatrice Distinguished Chair of Obstetrics and Gynecology at the University of Texas Southwestern Medical Center. He is also chair emeritus of the Department of Obstetrics and Gynecology, having served in that position for 22 years. Dr. Cunningham received his MD degree from the Louisiana State University School of Medicine and completed a residency in Obstetrics and Gynecology at Charity Hospital of New Orleans. Following this, he completed a fellowship in Maternal-Fetal Medicine at UT Southwestern and Parkland Hospital in Dallas, Texas. His early career was influenced by Dr. Jack Pritchard, and together they performed extensive clinical and laboratory research in preeclampsia and eclampsia, coagulopathies and other hematological complications of pregnancy, as well as a myriad of medical and surgical disorders complicating pregnancy. He has served as an examiner for the American Board of Obstetrics and Gynecology, served as tor for an NIH consensus conference, and is a member of the Society for Maternal-Fetal Medicine, Society for Gynecologic Investigation, and the American Gynecological and Obstetrical Society. Dr. Cunningham has served as senior editor of the 18th through 24th editions of Williams Obstetrics.
Lindheimer, Marshall D.
Dr. Marshall Lindheimer, a professor (emeritus) of Medicine, Obstetrics & Gynecology, and Clinical Pharmacology at the University of Chicago is a longtime admirer and was a longtime friend of the late Leon Chesley. Chief Editor of the second and third editions of this text and leader of the search for its current chief editor, Dr. Lindheimer prefers to be called "editor emeritus despite continuing to comment and publish in the area of the hypertension and renal disease in pregnancy. His CV contains over 400 publications including a monograph, other edited texts, reviews, text chapters and articles devoted to both basic and clinical research. Boarded in Internal Medicine and Nephrology, he is the recipient of many awards and honors that include an honorary membership in the Society of Maternal Fetal Medicine and an ad eundem of the Royal College of Obstetrics and Gynecology London. He has received an Honoris Causa degree from Bern University, the Chesley award from the International Society for the Study of Hypertension in Pregnancy, the Belding Scribner Award from the American Society of Nephrology and the Joseph Bolivar DeLee Humanitarian award from the Board of Directors at Lying-in Hospital, Chicago. Both the National Kidney Foundation of Illinois and the Preeclampsia Foundation have honored him as well. Of note on his wall is a congratulatory letter from President Obama, recognizing his accomplishments in regard to the health of pregnant women and their unborn children.