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Epigenetic Pharmacology and Therapeutics

  • ID: 2899396
  • Book
  • 128 Pages
  • Elsevier Science and Technology
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Epigenetic Pharmacology and Therapeutics highlights the interface between epigenetics and pharmacology by examining the role of epigenetics in the regulation of ADME genes and metabolism and delineating the importance of epigenetic enzymes in nuclear receptors signaling. This book discusses in detail the current trends in epigenetic therapy in cancer, epigenetic modifications and neurological disorders and epigenetic mechanisms in inflammation. A valuable guide for researchers and students interested in epigenetic pharmacology, this book provides new insight into the emerging role of epigenetic alterations as predictors of drug responses and potential tools to further drug therapy.

- Outlines the molecular mechanism of action of epigenetic drugs and their mechanism of resistance
- Highlights RNA interference and epigenetics in drug discovery
- Reviews the current status of epigenetic drugs in clinical trials
- Covers epigenetic biomarkers as new tools in current epigenetic and future drug therapy
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Chapter 1
Introduction to Epigenetics Chapter 2
Epigenetics Regulation of Nuclear Receptors and Transcriptional Factors Chapter 3
The Role of Epigenetics in Drug Responses Chapter 4
Epigenetic Treatments in Cancer Chapter 5
Epigenetic Modifications and Neurological Disorders: Potential Therapies Chapter 6
Epigenetic Mechanisms in Inflammation Chapter 7
Current Epigenetic Drugs in Clinical Trials Chapter 8
Epigenetic Biomarkers Chapter 9
Conclusions and Future Directions
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Konsoula, Zacharoula
Dr. Konsoula holds a PhD in pharmacology/ toxicology and post-doctoral in epigenetic oncology drug discovery. Her research experience is in the areas of epigenetic tumor biology, stem cells and preclinical pharmacology. Dr. Konsoula has published more than 25 peer reviewed research articles, abstracts, book chapters and review articles in the epigenetics, pharmacology / toxicology and radiation oncology research fields. She is a reviewer for the J Phar Tox Methods (August 2010- present) and Associate Editor for the journal Epigenetics in Cancer / Versita (June 2012- present). She is also a member of AACR, AAPS, ASCPT and SOT.
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