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Hyaluronan Signaling and Turnover, Vol 123. Advances in Cancer Research

  • ID: 2899432
  • Book
  • July 2014
  • Region: Global
  • 418 Pages
  • Elsevier Science and Technology
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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover.

- Provides information on cancer research- Outstanding and original reviews- Suitable for researchers and students

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1.Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy
2.Targeting Hyaluronic Acid Family for Cancer Chemoprevention & Therapy
3.Aberrant Post-Transcriptional Processing of Hyaluronan Synthase 1 in Malignant Transformation and Tumor Progression
4.Hyaluronan Synthases Post-Translational Regulation in Cancer
5.Hyaluronon-Coated Extracellular Vesicles
A Novel Link Between Hyaluronan and Cancer
6.Hyaluronan in the Healthy and Malignant Hematopoietic Microenvironment
7.Hyaluronan Regulation of Endothelial Barrier Function in Cancer
8.HAS2 and CD44 in Breast Tumorigenesis
9.CD44 is a Multidomain Signaling Platform that Integrates Extracellular Matrix Cues with Growth Factor and Cytokine Signals
10.Hyaluronan-CD44 Interaction Promotes Oncogenic Signaling, MicroRNA Functions, Chemoresistance and Radiation Resistance in Cancer Stem Cells Leading to Tumor Progression
11.Advances and Advantages of Nanomedicine in the Pharmacological Targeting of Hyaluronan-CD44 Interactions and Signaling in Cancer
12.Hyaluronan / RHAMM Interactions in Mesenchymal Tumor Pathogenesis: Role of Growth Factors
13.CD147: Regulator of Hyaluronan Signaling in Invasiveness and Chemoresistance
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Simpson, Melanie
Heldin, Paraskevi
Paraskevi Heldin, Ph.D., received her B.Sci. exam (Chemistry/Biochemistry Mathematics), Uppsala University in 1979 and her Ph.D., in Medical and Physiological Chemistry for studies on regulatory phosphorylation of proteins, Faculty of Medicine, Uppsala University, in 1987. After dissertation she changed research area and focused on the biology of hyaluronan under the supervision of Professor T.C. Laurent, Uppsala University. She worked at Department of Medical and Physiological Chemistry during 1987- 2000, and was awarded Docent appointment in Medical and Physiological Chemistry and Scientist Position from The Göran Gustafsson Foundation. Since 2001, she is Adjunct Associate Professor at the Department of Medical Biochemistry and Microbiology, and Associate Investigator and Head of the Matrix Biology Group in Ludwig Institute for Cancer Research, Uppsala, Sweden. Year 2013, she has appointed Adjunct Professor at the Department of Medical Biochemistry and Microbiology, Uppsala Unversity, Sweden. Dr Heldin's interests are focused on understanding the mechanisms of how hyaluronan-CD44 complexes interact with the receptors for the growth factors PDGF and TGFß for modulation of the proliferative and invasive behavior of malignant cells.
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