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Stellate Cells in Health and Disease

  • ID: 2936277
  • Book
  • 336 Pages
  • Elsevier Science and Technology
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Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs.

The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer.

Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain  sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology.

  • Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy.
  • Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology.
  • Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

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Chapter 1. History and Early Work
Chapter 2. Stellate Cell Culture Models
Chapter 3. Hepatic Fibrosis: A Global Clinical Problem
Chapter 4. Stellate Cells and Hepatic Fibrosis
Chapter 5. Cytokin Production and Signaling in Stellate Cells
Chapter 6. Stellate Cells, Portal Myofibroblasts and Epithelial-Mesenchymal Transition
Chapter 7. Matrix Melalloproteinases and their Inhibitors
Chapter 8. Matrix Melalloproteinases and their Inhibitors
Chapter 9. Stellate Cells and Liver Cancer
Chapter 10. Morphogens and hepatic stellate cell fate regulation
Chapter 11. Stellate Cells in alcoholic Steatohepatitis
Chapter 12. Stellate Cells as target for Reversal of Fibrosis/Cirrhosis
Chapter 13. Interactions of Stellate Cells with other Nonparenchymal Cells
Chapter 14. Stellate Cells in Regulation of Hepatocyte Survival and Functions
Chapter 15. Stellate Cells in hepatic Immunobiology
Chapter 16. Stellate Cell Depletion Models
Chapter 17. Stellate Cells in Nonhepatic Organs
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Gandhi, Chandrashekhar
Dr. Chandrashekhar Gandhi is a professor within the department of Surgery at the University of Cincinnati. His laboratory focuses on the mechanisms of intercellular communications that regulate the structure and function of the liver in physiology and pathology. Present research elucidates specific molecular and biochemical mechanisms underlying effects of stellate cells. Dr. Gandhi is a member of the American Association for Advancement of Science, The New York Academy of Sciences, American Society for Biochemistry and Molecular Biology, International Liver Transplantation Society, American Association for the Study of Liver Diseases, and the American Society for Investigative Pathology. He has contributed over 70 published research articles and owns the patent for "Diagnostic and Therapeutic Uses of Augmenter of Liver Regeneration (ALR) in Inflammatory Conditions” (PCT/US2008/075440).
Pinzani, Massimo
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