WTEC Panel Report on Tissue Engineering Research

  • ID: 2986257
  • Book
  • 268 Pages
  • Elsevier Science and Technology
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WTEC Panel on Tissue Engineering Research is a comparative review of tissue engineering research and development activities in the United States, Japan, and Western Europe conducted by a panel of leading U.S. experts in the field. This book covers biomaterials, cells, biomolecules, non-medical applications, engineering design, informatics, and legal and regulatory issues associated with tissue engineering research and applications.
This document will serve as a basis for continued dialogue within nations' tissue engineering research and development community and with other important stakeholders, providing guidance for future programs. This text highlights the necessity for providing continued and enhanced resources to further the progress in tissue engineering, harness developments, and maintain scientific and economic leadership.

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Foreword

List of Figures


List of Tables


Executive Summary


1. Introduction


Background: The Significance of Tissue Engineering


History of Tissue Engineering


Promise of Tissue Engineering


Other Applications


Emerging Industry of Tissue Engineering


Objectives of the WTEC Study


Scope and Methodology


Vision for the Future


Acknowledgements


References


2 Biomaterials


Introduction


U.S. R&D Activities


Japanese R&D Activities


European R&D Activities


Summary


References


3 Cells


Introduction


Analysis of Current State of the Art and Factors Influencing Progress


Control of Cell Proliferation and Differentiation


U.S. R&D Activities


Background


Current Efforts


Future Position


R&D Activities in Europe


Japan


Summary


References


4 Biomolecules


Introduction


Gene Transfer


Angiogenic Factors/Growth Factors


Differentiation Factors


Bone Morphogenic Proteins


References


5 Cell-Based Technologies: Non-Medical Applications


Introduction


Overview of R&D Activities


Summary


6 Engineering Design Aspects of Tissue Engineering


Introduction


Bioreactor Technology


Preservation of Cells and Engineered Tissues


Mass Transport Issues Following Implantation


Biomechanics Issues


Summary


References


7 Informatics and Tissue Engineering


Introduction


Informatics Components That Will Ultimately Support Tissue Engineering


U.S. R&D Activities


European R&D Activities


Japanese R&D Activities


Summary


References


8 Legal and Regulatory Issues


Introduction


FDA Regulation


Other Considerations Relevant to Engineered Tissues


Regulation of Pharmaceutical/Medical Human Tissue Products in Europe


Regulation of Pharmaceutical/Medical Human Tissue Products in Japan


Conclusion


References


Appendices


A. Biographies of Panelists


B. Site Reports-Europe


bwA, Aachen Centre of Competence: Biomaterials


Cell Lining GmbH


Berlin Workshop


ERA Consulting (UK), Ltd


ETH Zurich


European Agency for the Evaluation of Medicinal Products (EMEA)


European Molecular Biology Laboratory (EMBL)


German Cancer Research Center (DKFZ)


German Heart Institute


Humboldt University of Berlin, Charite


Biomaterial and Tissue Repair Laboratory (INSERM)


Imperial College of Science, Technology and Medicine


Imperial College of Science, Technology and Medicine


University of Glasgow


IsoTis (Technical Report)


IsoTis (Regulatory Report)


Kirchhoff Institute of Physics (KIP)


Manchester University


Max Planck Institute for Polymer Research


MeVis


Smith & Nephew Group Research Centre


University of Freiburg


University of Koln


University of Regensburg


University of Twente


C. Appendix C. Site Reports-Japan


Hokkaido University


Japan Tissue Engineering Company, Ltd


Keio University


Kyoto University


Kyushu University


Nippon Telegraph and Telephone Corporation (NTT) Basic Research Laboratories


Nagoya University


National Cancer Center Research Institute


National Institute for Advanced Interdisciplinary Research (NAIR)


National Institute of Bioscience and Human Technology


Institute of Physical and Chemical Research (RIKEN) Cell Bank


Tokyo Institute of Technology


Tokyo Women's Medical University


University of Tokyo


University of Tsukuba


D. Summary of the June 2000 U.S. Review Workshop


E. The Federal Investment in Tissue Engineering


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McIntire, Larry V.
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