+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)


Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

  • ID: 3025280
  • Book
  • January 2015
  • Elsevier Science and Technology

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents.

Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.

Note: Product cover images may vary from those shown
Chapter 1 Chemical modulators of protein misfolding, neurodegeneration and tau: What's not covered next
Chapter 2 Targeting the protein quality control (PQC) machinery: Chaperones & Co...
Chapter 3 Targeting proteasomal degradation of soluble, misfolded proteins: Ubi major
Chapter 4 Targeting unselective autophagy of cellular aggregates: A shotgun approach
Chapter 5 Targeting selective autophagy of insoluble protein aggregates: The sniper's philosophy
Chapter 6 Targeting assembly and disassembly of protein aggregates: A raggle-taggle bunch with high hopes
Note: Product cover images may vary from those shown
Pierfausto Seneci Associate Professor, Department of Organic and Industrial Chemistry, University of Milan, Milan, Italy.

Dr. Pierfausto Seneci is Associate Professor in the Department of Organic and Industrial Chemistry at the University of Milan. He is currently affiliated with the University of Milan Centre for Interdisciplinary Biomolecular Studies and Industrial Applications (CISI) Centre of Excellence, and is responsible for the Combinatorial Chemistry/High Throughput MedChem Laboratory. He has over 20 years of medicinal chemistry experience working in industry, and held business development positions with GSK, Sanofi, and start-up pharmaceutical companies including Sirenade and NiKem working in drug discovery, neurodegeneration, oncology, and antibacterials. He is author of approximately 80 papers on the topic and several book chapters, including the book "Solid-Phase Synthesis and Combinatorial Technologies” with Wiley-Interscience in 2000.
Note: Product cover images may vary from those shown