Sample preparation is applied to make real world samples amenable for chromatographic analysis, or to improve the results of this type of analysis. A wide variety of procedures are applied for this purpose, and their description is the main goal of the present book. The principles of these procedures are explained, discussing their advantages and disadvantages, and their applicability to different types of samples as well as their fit for different types of chromatographic analysis. This provides a guide for choosing the appropriate sample preparation for a given analysis. The book also contains numerous literature references and examples of sample preparation for different matrices. The material is presented in three parts, one discussing physical methods used in sample preparation such as filtration, distillation, solvent extraction, solid phase extraction, electro-separations.
- Presents in a systematic way numerous techniques applied for sample preparation for chromatographic analysis
- Provides an up to date source of information regarding the progress made in sample preparation for chromatography
- Describes examples for specific type of matrices, providing a guide for choosing the appropriate sample preparation method for a given analysis
Part 1: General concepts in sample preparation 1.Preliminaries to sample preparation 2. The role of sample preparation 3. Chromatography as a core step for an analytical procedure Part 2: Main sample preparation techniques 4. Mechanical processing in sample preparation 5. Phase transfer in sample preparation 6. Solvent extraction 7. Solid-phase extraction 8. Other sample preparation techniques not involving chemical modifications of the analyte 9. The role of derivatization in chromatography 10. Chemical reactions used in derivatizations 11. Chemical degradation of polymers for chromatographic analysis 12. Comments on sample preparation in chromatography for different types of materials
Dr. Serban C. Moldoveanu is Sr. Principal Scientist at R. J. Reynolds Tobacco Co. His research activity is focused on various aspects of chromatography including method development for the analysis by GC/MS, HPLC, and LC/MS/MS of natural products and cigarette smoke. He also performed research on pyrolysis of a variety of polymers and small molecules. He has over 100 publications in peer reviewed journals, eleven books, and several chapter contributions. He is a member of the editorial board of the Journal of Analytical Methods in Chemistry.
Dr. Victor David is a Professor and Head of the Department of Analytical Chemistry, University of Bucharest, Romania. He is the author of more than 120 publications, including 92 scientific papers in ISI international journals and 10 books and chapters in various Encyclopedias. He is also a reviewer at several international journals.