Translating Regenerative Medicine to the Clinic

  • ID: 3060347
  • Book
  • 354 Pages
  • Elsevier Science and Technology
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Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin.

Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole.

Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic.

- Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic- Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field- Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field- Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

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Introduction: Regenerative Medicine for Cardiovascular Disease-A Good Start
PART I: STEM CELLS: 
Chapter 1: Introduction and Overview of Stem Cells
Chapter 2: Mechanistic Insights from Pathologic Perspective
Chapter 3: Large Animal Models to Study Stem Cell Therapy
Section I. Body's Native Repair Mechanisms
Chapter 4. Evolution of understanding of the mechanisms of repair    
Chapter 5: Impact of Age on Stem Cell Function
Section II: Autologous Bone Marrow
Chapter 6: Bone Marrow Mononuclear Cells
Chapter 7: Chronic Limb Ischemia
Chapter 8: Chronic/Refractory Angina
Chapter 9: Acute Myocardial Infarction
A. European Experience:  Andreas Zeiher
B. US Experience: Jay Traverse
Chapter 10: Chronic Ischemic Heart Failure
Section III:  Autologous Adipose Derived Regenerative Cells
Chapter 11: Adipose Tissue
Section IV: Allogeneic Alternatives to Autologous Bone Marrow
Chapter 12: Overview of MSCs    
Chapter 13: Allogeneic vs Autologous Source: Comparative Effects
Chapter 14: Use of MSCs for AMI
Chapter 15: Combined Cell Strategies
Chapter 16: Heart Failure
Section V: Cardiac Progenitor Cells
Chapter 17:  C-Kit+ cells
Chapter 18:  Cardiospheres
Section VI: Other Allogeneic Sources of Stem Cells
Chapter 19:  Umbilical Cord, Placenta, Endometrium
Section VII. Genetic Engineering/Cell Transformation
Chapter 20:  Genetic Engineering of Fibroblasts to Cardiomyocytes
Chapter 21:  Transformation to inducible Pleuripotent Stem Cells
Chapter 22:  Transformation to MAPC's
Section VIII: METHODS OF DELIVERY: 
Chapter 23.  Transcoronary and Endocardial
Chapter 24.  Retrograde and Epicardial
Part II. TISSUE ENGINEERING:
Chapter 25.  Epicardial Patch
Chapter 26.  Matrix Scaffolds
Chapter 27.  Matrix plus cells
Chapter 28.  Biomaterial
Chapter 29:  Organogenesis
Part III. GENE THERAPY:
Chapter 30:  Pre-clinical Identification of target genes
Chapter 31:  SERCA-2a gene for recovery of inotropic function
Chapter 32:  SDF-1 Gene for Heart Failure Non-Inotropic Mechanisms
Chapter 33:  Gene Therapy for Angiogenesis: Chronic Limb Ischemia
Chapter 34:  Stem Cells Target Gene Transfected Stem Cells
Part IV: FUTURE DIRECTIONS:
Chapter 35:  CCTRN: Past, Present, and Vision for the Future
Chapter 36:  Signature of Responders-lessons from Bio-Repository
Chapter 37:  Adjunctive therapy with LVADs for Recovery
Chapter 38:  Trials in Non-Ischemic Heart Failure 
Chapter 39:  Enhancing Stem Cell Homing for Tissue Repair
Chapter 40:  Stroke: Pre-Clinical and Clinical Trial Data
SUMMARY
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Laurence, Jeffrey
Dr Laurence is pursuing the pathophysiology of cardiovascular and skeletal abnormalities linked to HIV disease and its therapies at Weill Cornell. Dr Laurence is the editor-in-chief of Translational Medicine, which Elsevier co-publishes with the CSCTR.
Baptista, Pedro
Atala, Anthony
Anthony Atala is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs. Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Stem Cells- Translational Medicine, Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of Tissue Engineering and Regenerative Medicine, Rejuvenation Research, and Gene Therapy and Regulation; as Executive Board Member or Section Editor of the International Journal of Artificial Organs, Organogenesis, and Current Urology Reports; and as Editorial Board member of Expert Opinion on Biological Therapy, Biomedical Materials, Journal of Tissue Science and Engineering, 3D Printing and Additive Manufacturing, Technology, the Journal of Urology, Recent Patents on Regenerative Medicine, BioMed Central-Urology, Urology, and Current Transplantation Reports. Dr. Atala is a recipient of many awards, including the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, the World Technology Award in Health and Medicine, presented to individuals achieving significant and lasting progress, the Samuel D. Gross Prize, awarded every 5 years to a national leading surgical researcher by the Philadelphia Academy of Surgery, the Barringer Medal from the American Association of Genitourinary Surgeons for distinguished accomplishments, the Gold Cystoscope award from the American Urological Association for advances in the field, the Ramon Guiteras Award for pioneering research in regenerative medicine and outstanding contributions as a scholar and teacher, the Innovation Award from the Society of Manufacturing Engineers for the creation of synthetic organs, and the Rocovich Gold Medal, awarded to a distinguished scientist who has made a major impact on science toward the understanding of human disease. In 2011 he was elected to the Institute of Medicine of the National Academy of Sciences.
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