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Epigenetics: Emerging Targets, Available Technologies, Expert Interviews, and an Epigenetic Community Perspective

  • ID: 3068117
  • Report
  • November 2013
  • Region: Global
  • 96 Pages
  • Insight Pharma Reports
The first part of this report covers necessary background information, mostly pertaining to epigenetic targets, and the reasons they are being investigated. Several companies have kindly disclosed several strategies, methods, and techniques that they use for either target identification or technology development.

Report Features Include:

- Insight Pharma Reports polled a survey which had more than 150 responses. Specific areas highlighted are targets under investigation, market outlook, and how partnerships with external organizations have advanced the industry
- Interviews with CEOs, CSOs, and Expert Scientists from Constellation Pharmaceuticals, Epizyme Inc., and EpiTherapeutics, Active Motif, Cayman Chemical, and Reaction Biology
- Company background information
- Specific pharmaceutical/biopharmaceutical companies and their strategies

Note: Product cover images may vary from those shown
Executive Summary

Part I: Epigenetic Background and Target Information

Chapter 1

What is epigenetics?
Histone modifications
Histone methyltransferases
Arginine methyltransferases (RMT)
Histone demethylases
Epigenetic readers

Part II: Targets in the Industry

Chapter 2

Constellation Pharmaceuticals
Company background
Areas of research
SWI/SNF
EZH2
DOT1L
BET bromodomains
Challenges encountered
Competitive advantage
Partnerships
Future endeavors
Interview with Robert Sims
Company background
Research objectives
Benefits and challenges
Future endeavors

Chapter 3

EpiTherapeutics
Company background
Areas of research
PLU1
FBXL10
GASC1
Chemistry platform
Challenges encountered
Competitive advantage
Partnerships and future endeavors
Interview with Martin Bonde
Company background
Areas of research
Chemistry platform
Challenges encountered
Competitive advantage
Partnerships
Future endeavors

Chapter 4

Epizyme Inc.
Company background
Areas of research
DOT1L
EZH2
Challenges encountered
Competitive advantage
Partnerships
Future endeavors
Interview with Jesse Smith
Background
Areas of research
Target validation
Use of biomarkers
Challenges encountered
Partnerships
Future endeavors

Part III: Rising Technologies and Company Strategies

Chapter 5

Active Motif
Company background
Chromatin Immunoprecipitation (ChIP) technology
Competitive advantage
Challenges encountered
Validating antibodies using ChIP, ChIP-chip, and ChIP-Seq
Partnerships and strategies
Future endeavors
Interview with Kyle Hondorp
Company background
Immunoprecipitation technology
Challenges encountered
Future endeavors
Partnerships and growth

Chapter 6

Cayman Chemical
Company background
Applications
Time-resolved fluorescence resonance energy transfer (TR-FRET) assays
S-adenosyl-L-methionine (SAM)-screener assays
Challenges encountered
Partnerships
Future outlook
Interview with Dr. Levi Blazer
Company background
Partnerships
Areas of research
Assays
Challenges encountered
Future endeavors

Chapter 7

Reaction Biology Corporation
Company background
Reaction Biology Corporation’s role in epigenetics
Competitive strategies
Partnerships
Future outlook
Interview with Haiching Ma
Company background
Areas of research
Partnerships
Future expectations

Part IV: Epigenetics in the Community

Chapter 8

Survey results
Areas of study
Market outlook
Partnerships

References
Note: Product cover images may vary from those shown

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