Carbonic anhydrases (CAs, EC 220.127.116.11) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology.
- Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts
- Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes
- Identifies new targets for drug design studies
- Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications
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PART I INTRODUCTION 1. Carbonic Anhydrases: an overview
PART II CARBONIC ANHYDRASES AS DRUG TARGETS 2. Human Carbonic Anhydrases: catalytic properties, structural features and tissue distribution 3. Carbonic Anhydrase I 4. Carbonic Anhydrase II as target from drug design 5. Carbonic Anhydrase III 6. Carbonic Anhydrase IV 7. The structure, physiological role and potential medicinal applications of Carbonic Anhydrase V 8. Secreted Carbonic Anhydrase Isoenzyme VI 9. Carbonic Anhydrase VII 10. Tumor associated carbonic Anhydrases IX and XII 11. Carbonic anhydrase XIII 12. Carbonic anhydrase XIV: structure, functions and potential medical applications 13. Acatalytic Carbonic anhydrases (CAs VIII, X, XI) 14. Beta-class Carbonic anhydrases: general features and medical implications 15. Bacterial Carbonic Anhydrases as drug targets
PART III CARBONIC ANHYDRASES FOR BIOTECHNOLOGICAL APPLICATIONS 16. Engineered mammalian Carbonic Anhydrases for CO2 capture 17. Carbonic anhydrases from extremophiles and their biotechnological applications 18. Carbonic Anhydrases of environmentally and medically relevant anaerobic prokaryotes 19. Delta Carbonic anhydrases: structure, distribution and potential roles 20. CDCA1 from Thalassiosira weissflogii as representative member of zeta-class CAs: general features and biotechnological applications of anhydrases 21. Carbonic anhydrases as esterases and their biotechnological applications
Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990 he became assistant and then associate professor of chemistry at the University of Bucharest. He was a visiting scholar at University of Florida, Gainesville, USA, at Grifitth University, Brisbane, Australia and visiting professor at University of La Plata, Argentina. In 1995 he moved at the University of Florence, Italy, where he is currently assistant professor of pharmaceutical chemistry. His main research interests include medicinal chemistry, design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 700 papers in these fields.
De Simone, Giuseppina
Giuseppina De Simone was born in Naples, Italy, and graduated in chemistry at the University of Naples Federico II (1993). She worked from August 1994 to January 1995 at the Drug Design Group-Sandoz Pharma AG in Basel, and from September 1995 to February 1996 at the University of Pavia. From November 1996 to January 1997 she was visiting scientist at the Max Plank Institute- Hamburg Germany. In 1998 she received her PhD at the University of Naples. Since 2003, she is Senior Researcher at the Institute of Biostructures and Bioimaging (IBB) of the Italian National Research Council. Her main research interests include X-ray crystallography of macromolecules, structure based drug design, carbonic anhydrases, serine proteases, esterases/lipases, peptide nucleic acids. She has published more than 90 papers in these fields.