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The Retinoids. Biology, Biochemistry, and Disease

  • ID: 3110360
  • Book
  • 608 Pages
  • John Wiley and Sons Ltd
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The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. The book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.

The text is divided into five parts, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.

Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

An up–to–date synthesis of research on retinoids

Covers molecular mechanisms, pathway evolution, control of gene expression, and functions in development and adult physiology

Integrates basic biology and biochemistry with roles in disease and potential for therapies

Authored by internationally recognized leaders in the field

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Contributors ix

Preface xiii

Part I: Vitamin A metabolic and enzymatic pathways 1

1 Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms 3William S. Blaner and Yang Li

2 Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids 35Earl H. Harrison and Carlo dela Senã s

3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets 57Joseph L. Napoli and Charles R. Krois

4 Evolution of the Retinoic Acid Signaling Pathway 75Vincent Laudet, Elisabeth Zieger, and Michael Schubert

Part II: Biochemistry and cellular biology of retinoic acid signaling 91

5 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post–Translational And Epigenetic Regulatory Mechanisms 93Marilyn Carrier and Cécile Rochette–Egly

6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes 117Li–Na Wei

7 Retinoid Receptors: Protein Structure, Dna Recognition and Structure Function Relationships 131William Bourguet and Dino Moras

8 How the RAR RXR Heterodimer Recognizes the Genome 151Sylvia Urban, Tao Ye, and Irwin Davidson

9 Retinoid Receptor–Selective Modulators: Chemistry, 3D Structures and Systems Biology 165Marco–Antonio Mendoza–Parra, William Bourguet, Angel R. de Lera, and Hinrich Gronemeyer

10 Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid–Related Molecules are Ligands for the Small Heterodimer Partner (SHP) Orphan Receptor 193Marcia I. Dawson and Zebin Xia

11 The Dual Transcriptional Activity of Retinoic Acid 273Noa Noy

12 Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice 291Lorraine J. Gudas


13 Retinoic Acid Signaling and Central Nervous System Development 309Malcolm Maden

14 The Role of Retinoic Acid in Limb Development 339Gregg Duester

15 Retinoic Acid Signaling and Heart Development 353Stéphane Zaffran and Karen Niederreither

16 Retinoic Acid in the Developing Lung and Other Foregut Derivatives 371Wellington V. Cardoso and Felicia Chen

17 Retinoic Acid and the Control of Meiotic Initiation 383Josephine Bowles and Peter Koopman


18 Retinoids and the Visual Cycle: New Actors for an OLD Function 403Darwin Babino and Johannes von Lintig

19 Retinoid Signaling in the Central Nervous System 421Peter McCaffery and Wojciech Kre z el

20 Retinoid Turnover and Catabolism: Influences of Diet and Inflammation 449A. Catharine Ross and Reza Zolfaghari

21 Retinoids and the Immune System 465J. Rodrigo Mora and Makoto Iwata

22 Retinoic Acid Receptor Signaling in Post–Natal Male Germ Cell Differentiation 485Manuel Mark and Norbert B. Ghyselinck


23 Epidemiology and Prevention of Vitamin a Deficiency Disorders 507Keith P. West, Jr.

24 Retinoid Pathway Gene Mutations and the Pathophysiology Of Related Visual Diseases 529Yaroslav Tsybovsky and Krzysztof Palczewski

25 Retinoic Acid in Acute Myeloid Leukemias 543Hugues de Thé and Pierre Fenaux

26 Advances in the Use of Retinoids in Cancer Therapy and Prevention 557Michael J. Spinella, Sarah J. Freemantle, and Ethan Dmitrovsky

Index 575

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Pascal Dollé
Karen Niederreither
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