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Disordered Pharmaceutical Materials

  • ID: 3110499
  • Book
  • 544 Pages
  • John Wiley and Sons Ltd
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A one–stop resource for researchers, developers, and post graduate students in pharmaceutical science. This handbook and ready reference provides detailed, but not overloaded information –– presenting the topic without unnecessarily complex formalism.

As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, as well as preparation and characterization techniques for the target–oriented development of drug delivery systems based on disordered crystals and amorphous solids. Special attention is paid to examine the different facets and levels of disorder in their structural and dynamic aspects as well as the effect of disorder on dissolution and stability. Chapters on processing induced disorder and on patenting issues round off the book. As a result the book helps overcoming the challenges of using these materials in the pharmaceutical industry.

For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.
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FUNDAMENTAL ASPECTS OF DISORDER

Disorder and Structure: Existence and Absence of Long Range Order

Disorder and Molecular Mobility

Disorder and Thermodynamics: Entropy and Role of Disorder in the Stability of Physical States

Chemical Disorder

Short Range Organization in Disordered Materials: Static and Dynamic Intermolecular Correlations

RELEVANCE OF DISORDER FOR PHARMACEUTICAL PRODUCTS

Disorder and Solubility

Disorder and Stability (Physical and Chemical)

Disorder and Drug Delivery

Drawback and Opportunities of Disorder

EXPERIMENTAL METHODS FOR THE INVESTIGATION OF DISORDERED MATERIALS

Investigation of Structure: Diffraction Experiments, Spectroscopies

Investigation of Mobility (Relaxations and Vibrations)

Thermodynamic and Calorimetric Investigations

Chemical Aspects

Imaging Methods

HOW DISORDERED CAN PERFECT MOLECULAR CRYSTALS BE?

Condition for the Existence of a Crystalline Order

Disordered Perfect Crystals: Substitutional, Conformational, Rotational Disorder

Crystalline Polymorphism and Disorder

Order–Disorder Phase Transitions in Molecular Crystals

Static and Dynamic Disorder in Crystals: Vibrations, Molecular Rotations, Solid Solutions

Defective Crystals

Dislocation Disorder

Microcrystalline Order

Experimental Consequences

AMORPHOUS AND GLASSY STATE

Molecular Organization in Amorphous Molecular Solids

Intermediate Range Order

Metastability and Instability of Amorphous Materials

Crystallization out of the Amorphous State;

Vitrification Condition;

Glass Transition at Tg

Molecular Mobility in the Amorphous Materials Above and Below Tg

Aging of Glasses

Glass Transition of Solutions

AMORPHOUS PHARMACEUTICALS

Preparation Techniques: Spray Drying, Freeze Drying, Extrusion, Milling

Impacts of Glass Properties on Mechanical and Surface Properties: Agglomeration, Flowability, Caking, Dissolution

Stability Issues and Possible Stability Manipulations

Amorphous Intermediates in Cocrystal Formation

MESOMORPHIC MATERIALS FOR DRUG DELIVERY

Liquid Crystals

Plastic Crystals

Macromolecular Disorder

Solubilities of Drug in Polymer

Release of a Drug from Dissolving Polymer

Gel Formation, Hydrogels

NUMERICAL MODELING OF DISORDERED PHARMACEUTICAL MATERIALS

Validity of Force Fields Used in Drug Molecular Modeling

Property–dependent Choice of Simulation Models

Modeling and Prediction of Properties

Modeling as an Help to Interpret Data

PROCESS AND DISORDER

Disorder Accidentally or Unavoidably Produced in the Course of Processing Ordered Materials

Processing of Disordered Materials

PATENTING OF DISORDERED PHARMACEUTICAL PRODUCTS

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Marc Descamps
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