Epigenomic Medicine II - Haematological Malignancies

  • ID: 3144239
  • Book
  • Region: Global
  • 97 Pages
  • Research Signpost
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Neoplasia originates from the Hellenic terms meaning new growth and encompasses benign, pre-malignant (carcinoma in situ) and malignant conditions. Similarly, the word oncology which refers to the study of tumours or neoplasms originates from the Hellenic term “oncos” (= tumour). Further, the word cancer is of Hellenic origin from the term “karkinos” (= giant crab). Cancer represents a complex collection of diseases with multi-faceted genetic and epigenetic aberrations. While the central dogma, which dictates that cancer is the result of an accumulation of genetic mutations, persists, our textbook view is changing with advances in epigenetic research.

Indeed, it accepted that an epigenetic aberration may be considered one of the two “hits” in Knudson’s classical “two-hit” model of cancer. This volume of “Epigenomic Medicine” is focussed on haematological malignancies which in themselves represent a complex heterogeneous group of disorders. Non-Hodgkin’s lymphoma and leukemia account for approximately 5% and 3%, respectively, whereas other haematological malignancies are rare. This volume is comprised essentially of three discrete sections. Section one, Chapters 2-5, is focussed on the aetiology, pathobiology and treatment of leukaemia which formed the basis of Dr Kwa’s PhD thesis.

The second section, Chapters 6 & 7, is related to the pathogenesis and therapeutic strategies for cutaneous T-cell lymphoma. The final section, Chapters 8 & 9, provides an account of emerging, synthetic and natural epigenome-modifying compounds. Chapter 1 provides a brief overview of the genetic and epigenetic principles associated with neoplasia and brings the discussion of haematological malignancies into context. Overall, this volume of “Epigenomic Medicine” provides an overview of the key concepts related to neoplasia and haematological malignancies, which can serve as ideal background reading in the field.
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1. Genetic and epigenetic events in cancer: An overview
Faith AA Kwa and Tom C Karagiannis

2. Pathobiology of acute leukaemias
Faith AA Kwa and Tom C Karagiannis

3. Aetiology and pathogenesis of chronic leukaemias
Faith AA Kwa and Tom C Karagiannis

4. Diagnostic and prognostic tools for leukaemia
Faith AA Kwa and Tom C Karagiannis

5. Current therapies for leukaemia
Faith AA Kwa and Tom C Karagiannis

6. Pathobiology of cutaneous T-cell lymphoma
Annabelle L Rodd, Faith AA Kwa and Tom C Karagiannis

7. Conventional and novel therapies for cutaneous T-cell lymphoma
Annabelle L Rodd, Faith AA Kwa and Tom C Karagiannis

8. Histone deacetylase inhibitors in the treatment of haematological malignancies
Faith AA Kwa, Paul V Licciardi, Annabelle L Rodd, Gulcan Sarila, Katherine Ververis and Tom C Karagiannis

9. Dietary epigenome modifying compounds for the treatment of cancer
Paul V Licciardi, Faith AA Kwa, Natasha Di Costanzo, Katherine Ververis and Tom C Karagiannis

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Tom C. Karagiannis and Faith A.A. Kwa
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