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The Treatment of Epilepsy. 4th Edition

  • ID: 3148867
  • Book
  • 1072 Pages
  • John Wiley and Sons Ltd
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An indispensable clinical reference work which offers a clear practical clinical guide to the whole field of epilepsy therapy.

A wide range of treatment options are available for epilepsy, which depend on the nature of the epilepsy and the circumstances of the individual patient. Identifying the best regimen can be complex, and neurologists, paediatricians, epileptologists and trainees need a clear, concise yet comprehensive guide to the best treatment options.

The Treatment of Epilepsy, fourth edition, provides such a guide, describing all conventional pharmacological, medical and surgical options available for the treatment of epilepsy, and putting them in their appropriate clinical context. The book is compiled by three editors actively involved with the International League of Epilepsy, and written by renowned international experts in the field from 18 countries. 

  • This fourth edition has been extensively revised incorporating the many recent developments in therapy,
  • The first two sections cover the background to, and principles of, treatment in different clinical situations,
  • Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti–epileptic drug and covering all clinically–relevant aspects,
  • Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach,
  • Drug and prescribing data presented in clear tables for quick clinical referral,
  • The text consists of 81 chapters and a historical introduction, and is now in full color with many clear tables and figures.

 Praise for previous editions:

"Treatment of Epilepsy is a vital contribution to the field. The book′s primary focus is on the medical and surgical evaluation and treatment of the disease. Experts around the globe who have made seminal contributions to the treatment of epilepsy have contributed to the book, which preserves its flow and focus extremely well. ′This book is highly recommended′ ′for anybody who is involved in the evaluation and medical care of patients with epilepsy.′"  (NEJM, February 2005)

"I would highly recommendThe Treatment of Epilepsy for neurologists, neurosurgeons, psychiatrists, pediatricians, and internists, as well as nurse practitioners, physician′s assistants, and others who are interested in delving into the details of the treatment of epilepsy." (Epilepsy & Behavior, 6 October 2010)
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List of Contributors

Preface to the Fourth Edition

Preface to the First Edition

Historical Introduction: The Drug Treatment of Epilepsy from 1857 to 2015Simon Shorvon

Section I Introduction (Lead editor: Simon Shorvon)

1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE 1Simon Shorvon

2 Differential Diagnosis of Epilepsy 24Mark Cook

3 Mechanisms of Epileptogenesis 38Giuliano Avanzini and Silvana Franceschetti

4 Antiepileptic Drug Discovery 52H. Steve White and Melissa Barker–Haliski

5 Antiepileptic Drug Development 61Dieter Schmidt

6 Mechanisms of Antiepileptic Drug Action 75Matthew C. Walker and Rainer Surges

7 Mechanisms of Drug Resistance and Tolerance 92Wolfgang Löscher and Dieter Schmidt

8 Epilepsy Biomarkers 103Jerome Engel, Jr. and Asla Pitkänen

Section II Principles of Medical Management (Lead editor: Simon Shorvon)

9 General Principles of Medical Management 110Emilio Perucca

10 Pharmacokinetic Optimization of Therapy 124Svein I. Johannessen, Cecilie Johannessen Landmark and Emilio Perucca

11 Management of Chronic Active Epilepsy in Adults 139Simon Shorvon

12 Management of Epilepsy in Remission 148Patrick Kwan, Howan Leung and Xiaoting Hao

13 Management of Epilepsy in Neonates and Infants 156Elissa G. Yozawitz and Solomon L. Moshé

14 Management of Childhood Epilepsy Syndromes 174Colin D. Ferrie

15 Management of Epilepsy in People with Intellectual Disabilities 193Eylert Brodtkorb

16 Management of Epilepsy in the Elderly 205Hiba Arif Haider and Lawrence J. Hirsch

17 Emergency Treatment of Seizures and Status Epilepticus 221Matthew C. Walker and Simon Shorvon

18 Management of Medical Comorbidity Associated with Epilepsy 245Gagandeep Singh

19 Psychiatric Features of Epilepsy and their Management 259Brent Elliott and Simon Shorvon

20 Prevention and Management of Side–effects of Antiepileptic Drugs 275Gaetano Zaccara and Piero Perucca

21 Ketogenic Diets 288Eric H. Kossoff and Courtney A. Haney

22 Complementary and Alternative Treatments for Epilepsy 298Sallie Baxendale

23 Reproductive Aspects of Epilepsy Treatment 311Torbjörn Tomson

24 Genetic Counselling in Epilepsy 323Federico Zara

25 Drug Interactions 344Edoardo Spina and Domenico Italiano

26 Medical Treatment of Epilepsy in Resource–Poor Countries 360Patrick Adjei

Section III Antiepileptic Drugs (Lead editor: Emilio Perucca)

27 Introduction to the Choice of Antiepileptic Drugs 365Emilio Perucca

28 Acetazolamide 376Miri Y. Neufeld

29 Adrenocorticotropic Hormone and Corticosteroids 388Federico Vigevano and Maria Roberta Cilio

30 Benzodiazepines Used in the Treatment of Epilepsy 398Eugen Trinka and Francesco Brigo

31 Brivaracetam 418Joseph D’Souza and Emilio Perucca

32 Carbamazepine 431Torbjörn Tomson and Svein I. Johannessen

33 Eslicarbazepine Acetate 447Meir Bialer and Christian Elger

34 Ethosuximide 460Tracy A. Glauser and Emilio Perucca

35 Felbamate 472Ilo E. Leppik and James R. White

36 Gabapentin 479Ernest R. Somerville, Andrew W. Michell and Arjune Sen

37 Lacosamide 489Rajesh Sachdeo and Roopal Karia

38 Lamotrigine 498Awais Riaz and Fumisuke Matsuo

39 Levetiracetam 516Derek J. Chong and Jacqueline A. French

40 Oxcarbazepine 533Edward Faught and Hyunmi Kim

41 Perampanel 546Martin Brodie

42 Phenobarbital, Primidone and Other Barbiturates 555Roberto Michelucci and Elena Pasini

43 Phenytoin 574Mervyn J. Eadie

44 Piracetam 589Simon D. Shorvon

45 Pregabalin 595Sylvain Rheims and Philippe Ryvlin

46 Retigabine 606Michel Baulac

47 Rufinamide 617Victor Biton

48 Stiripentol 628Tapani Keränen

49 Tiagabine 633Reetta Kälviäinen

50 Topiramate 642J. Helen Cross and Catherine J. Riney

51 Valproate 652Anthony G. Marson and Graeme J. Sills

52 Vigabatrin 667Günter Krämer and Gabriele Ch. Wohlrab

53 Zonisamide 680Michel Baulac

54 Other Less Commonly Used Antiepileptic Drugs 689Martin Holtkamp

55 Drugs in Clinical Development 701Norman Delanty and H. Steve White

Section IV Presurgical Assessment and Epilepsy Surgery (Lead editor: Jerome Engel, Jr.)

56 Overview of Surgical Treatment for Epilepsy 709Jerome Engel, Jr.

57 Scalp EEG in the Epilepsy Surgery Evaluation 723Christine B. Baca and John M. Stern

58 Invasive EEG in Presurgical Evaluation of Epilepsy 733Dennis Spencer, Dang K. Nguyen and Adithya Sivaraju

59 MEG in Epilepsy Surgery Evaluation 756Hermann Stefan and Paul Boon

60 MRI in Presurgical Evaluation 764Christian E. Elger and Bernd Weber

61 PET and SPECT in Presurgical Evaluation of Epilepsy 775Karolien Goffin and Wim Van Paesschen

62 Special Neurophysiological Techniques 787François Mauguière and Julien Jung

63 Neuropsychological Testing in Presurgical Evaluation 804Marilyn Jones–Gotman and Gail L. Risse

64 Presurgical Psychiatric Evaluation 817Andres M. Kanner

65 Mesial Temporal Lobe Surgery and Other Lobar Resections 829James Leiphart and Itzhak Fried

66 Resective Surgery of Neoplasms 842Nicholas M. Wetjen and Gregory D. Cascino

67 Resective Surgery of Vascular and Infective Lesions for Epilepsy 858Christopher E. Uff and Neil D. Kitchen68 Surgery of Developmental Anomalies Causing Epilepsy 878Ahyuda Oh, Joshua J. Chern and Youssef G. Comair

69 Hemispheric Operations for Epilepsy 887Georg Dorfmüller, Christine Bulteau and Olivier Delalande

70 Corpus Callosum Operations 895David W. Roberts

71 Hypothalamic Hamartoma 903John F. Kerrigan

72 Multiple Subpial Transection 916Adriana Bermeo–Ovalle and Michael C. Smith

73 Awake Surgery for Epilepsy 922Webster H. Pilcher

74 Epilepsy Surgery in Children 931Jason S. Hauptman and Gary W. Mathern

75 Complications of Epilepsy Surgery 941Charles E. Polkey

76 Anaesthesia for Epilepsy Surgery 952Barbara M. Van de Wiele

77 Vagus and Trigeminal Nerve Stimulation 959Steven C. Schachter

78 Brain Stimulation for Epilepsy 967Gregory K. Bergey and Robert S. Fisher

79 Non–Resective Approaches for Medically Intractable Epilepsy 980Thomas J. Gianaris, Andrea G. Scherer and Nicholas M. Barbaro

80 Future Focal Treatment Approaches to Epilepsy 987Laura Mantoan Ritter and Hannah Cock

81 Epilepsy Surgery in Countries with Limited Resources 999Andre Palmini and Kurupath Radhakrishnan

Index 1008

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Simon Shorvon
Emilio Perucca
Jerome Engel Jr.
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