Doing Research in Emergency and Acute Care. Making Order Out of Chaos

  • ID: 3148897
  • Book
  • 288 Pages
  • John Wiley and Sons Ltd
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A practical guide to understanding and navigating the unique challenges faced by physicians and other professionals who wish to undertake research in the ED or other acute care setting.

Focusing on the hyper–acute and acute care environment and fulfilling two closely–related needs:

1) the need for even seasoned researchers to understand the specific logistics and issues of doing research in the ED; and 2) the need to educate clinically active physicians in research methodology.

This new text is not designed to be a complex, encyclopedic resource, but instead a concise, easy–to–read resource designed to convey key need–to–know information within a comprehensive framework. Aimed at the busy brain, either as a sit–down read or as a selectively–read reference guide to fill in knowledge gaps, chapters are short, compartmentalized, and are used strategically throughout the text in order to introduce and frame concepts. This format makes it easy – and even entertaining – for the research novice to integrate and absorb completely new (and typically dry) material.

The textbook addresses aspects of feasibility, efficiency, ethics, statistics, safety, logistics, and collaboration in acute research. Overall, it grants access for the seasoned researcher seeking to learn about acute research to empathically integrate learning points into his or her knowledge base.

As the ED is the primary setting for hyper–acute and acute care, and therefore a prime site for related clinical trial recruitment and interventions, the book presents specific logistical research challenges that researchers from any discipline, including physicians, research nurse coordinators, study monitors, or industry partners, need to understand in order to succeed.

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List of contributors, ix

Part 1: Getting ready: Preparing for your research study

1 Aspects of research specific to acute care, 3Jarrod M. Mosier and Peter Rosen

2 Aspects of feasibility in research, 7Kama Z. Guluma

3 How do I formulate a research question?, 13Michael P. Wilson

4 Evidence ]based medicine: Finding the knowledge gap, 17Eddy Lang and Zubair Bayat

5 How to carry out an efficient literature search, 21Aleksandr Tichter, Louise Falzon, and Peter Wyer

6 What do I need to know to get started with animal and basic science research?, 31George J. Shaw

7 The IRB process: How to write up a human studies protocol, 37Christian Tomaszewski

8 Ethics in research: How to collect data ethically, 45Nas Rafi and Brian Snyder

9 Safety in research: How to ensure patient safety?, 53Robert Grover and Vicken Y. Totten

Part 2: Getting it done: Doing your research study

10 How to design a study that everyone will believe: Minimizing bias and confounding, 61Michael Witting

11 How to design a study that everyone will believe: An overview of research studies and picking the right design, 65Julian Villar, Jennifer Lanning, and Robert Rodriguez

12 How to design a study that everyone will believe: Random selection and allocation of patients to treatment conditions, 71Katie L. Tataris, Mary Mercer, and Prasanthi Govindarajan

13 How to design a study that everyone will believe: Surveys, 79Edward M. Castillo and Gary M. Vilke

14 How to design a study that everyone will believe: Retrospective reviews, 85Jonathan Auten and Paul Ishimine

15 How to design a study that everyone will believe: Prehospital studies, 93Christopher Kahn

16 How to design a study that everyone will believe: Ethical concepts for special populations in emergency research, 97Kimberly Nordstrom

17 How to design a study that everyone will believe: Industry studies, 105Richard F. Clark and Alicia B. Minns

18 How to design a study that everyone will believe: Prospective studies, 115Gary Gaddis

19 How to design a study that everyone will believe: effectiveness, safety, and the intention to treat, 121Ashleigh Campillo, Christopher J. Coyne, and Juan A. Luna

20 How to design a study that everyone will believe: Emergency department operations and systems, 129Vaishal Tolia

21 How to design a study that everyone will believe: The challenges of doing international research, 133Vicken Y. Totten

22 The development of clinical prediction rules, 139Benton R. Hunter and Christopher R. Carpenter

23 Testing the safety and efficacy of devices: Device safety, as well as obtaining an IDE (investigational device exemption) from the FDA, 149Sean ]Xavier Neath

24 Privacy in research: How to collect data safely and confidentially, 155Gary M. Vilke and Edward M. Castillo

25 How do I establish a research assistant program?, 161Judd E. Hollander

26 How to complete a research study well and in a minimum of time: The importance of collaboration, 167Austin Hopper and Michael P. Wilson

Part 3: Getting it out there: Analyzing and publishing your study

27 Eliminating common misconceptions to enable intelligent use of biostatistics: How can a novice use statistics more intelligently?, 175Gary Gaddis

28 Basic statistics: sample size and power: How are sample size and power calculated?, 183Manish Garg, Richard Harrigan, and Gary Gaddis

29 Basic statistics: Means, P values, and confidence intervals, 191Daniel del Portal and Richard Harrigan

30 Basic statistics: Assessing the impact of therapeutic interventions with odds–ratios, relative risk, and hazard ratios, 199Jesse J. Brennan and Edward M. Castillo

31 Basic statistics: Assessing the impact of a diagnostic test; choosing a gold standard, sensitivity, specificity, PPV, NPV, and likelihood ratios, 205Stephen R. Hayden

32 Advanced biostatistics: Chi ]square, ANOVA, regression, and multiple regression, 213Gary Gaddis

33 Can I combine the results of this study with others? An introduction to systematic reviews, 223Brian H. Rowe

34 How to write a scientific paper for publication, 231Stephen R. Hayden

35 How do I make reviewers happy? The review process: What do reviewers look for in a manuscript? What is the review process?, 239David J. Karras and Jacob W. Ufberg

36 How do I write a grant?, 247Zachary D.W. Dezman and Jon Mark Hirshon

37 How to make an academic career: Developing a successful path in research, 253Deirdre Anglin and Michael Menchine

Glossary, 259

Index, 267

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Michael P. Wilson
Kama Z. Guluma
Stephen R. Hayden
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