Current Approach to Hyperammonemia

  • ID: 3315557
  • Book
  • Future Medicine Ltd
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Hyperammonemia is a metabolic condition characterized by increased concentrations of ammonia in the blood. Due to the neurotoxic effects of ammonia, a nitrogenous compound, it is a highly dangerous condition, particularly during infantile and early childhood development. Ammonia-induced damage to the brain may fast become irreversible depending on the duration and extent of hyperammonemia. Despite this, the mechanisms by which brain function is severely hampered or irreversibly destroyed have not yet been fully elucidated. This book brings together basic scientists and researchers, as well as clinicians caring for pediatric or adult patients, in an effort to shed light on the various biochemical, analytical and clinical aspects of hyperammonemia; it covers current approaches and the latest advances in state-of-the-art management, as well as providing future perspectives on the condition.
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1. Ammonia metabolism in humans: production and removal: Daniel Rabier

2. Neurobiology of ammonia: Vicente Felipo

3. Ammonia toxicity to the brain: Olivier Braissant

4. Oxidative and nitrosative stress in ammonia neurotoxicity: Marta Skowronska & Jan Albrecht

5. Preanalytical and analytical aspects of ammonia determination: Camilla Scott & Simon Olpin

6. Inherited disorders leading to hyperammonemia in children: Arunabha Ghosh & Andrew Morris

7. Inherited disorders leading to hyperammonemia in adults: Valerie Walker

8. Role of cerebral ammonia toxicity in hepatic encephalopathy: Natalia Qvartskhava, Markus S Jördens, Boris Görg & Dieter Häussinger

9. Role of brain imaging for demonstrating ammonia-induced changes: Ileana Pacheco-Colón, Stanley Fricke & Andrea Gropman

10. Medical treatment of hyperammonemia: Marie-Cécile Nassogne & Marie-Françoise Vincent

11. Extracorporeal detoxification as a treatment of acute hyperammonemia: Nicholas Ah Mew & Marshall Summar

12. Organ and cell-based replacement therapy for the treatment of urea cycle disorders: Shirou Matsumoto & Fumio Endo

13. New treatment options for hyperammonemia: George A Diaz
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