The book discusses how this can lead to alcoholic liver disease (ALD) as well as contribute to the onset of Type 2 diabetes and the metabolic syndrome. It also explores how alcohol affects nutrient absorption in the gastrointestinal tract and can lead to anemia and reduced amounts of fat soluble vitamins.
This book explores both the primary and secondary consequences of alcohol consumption. Chapters in the first section investigate the basic science of alcohol metabolism - focusing on how alcohol and its toxic metabolites disrupt and impair normal nutrient regulation at the molecular level. Further chapters explore how alcohol affects many extra-hepatic organs and tissues as well as the secondary consequences of alcohol consumption such as reduced levels of minerals like magnesium, calcium, and trace elements like zinc.
- Offers a valuable resource for nutrition researchers and nutritionists who study alcohol-related diseases and attempt to treat them through nutritional strategies- Explores how alcohol and its toxic metabolite acetaldehyde disrupt and impair normal macro and micro nutrient regulation at the molecular level - Investigates how alcohol affects and interferes with cell signaling, cell death pathways, calcium homeostasis leading to osteoporosis, oxygen balance, as well as the pathophysiology of alcohol consumption and abuse
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Section 1. General and Introductory Aspects 1. Nutrients and Liver Energy Metabolism Daniel Gyamfi and Kwabena Owusu Danquah 2. Alcohol Metabolism: general aspects Reem Ghazali and Vinood B. Patel Section 2. Molecular biology of the cell 3. Alcohol and aldehyde dehydrogenases: molecular aspects Kwabena Owusu Danquah 4. Apoptosis and alcohol F.A. Middleton 5. Pathogenic Mechanisms in Alcoholic Liver Disease (ALD): emerging role of Osteopontin Wing-Kin Syn and Jason D. Coombes 6. The Role of CD36 in the Pathogenesis of Alcohol-Related Disease Caleb T. Epps, Robin D. Clugston, Amit Saha, William S. Blaner and Li-Shin Huang 7. Thiamine deficiency in alcoholics Ann M. Manzardo 8. Vitamin B regulation of Alcoholic Liver Disease Charles H. Halsted and Valentina Medici 9. Vitamin D and alcohol interactions and implication for bone Emilio Gonzalez-Reimers, Geraldine Quintero-Platt, Antonio Martinez-Riera and Francisco Santolaria-Fernandez 10. Antioxidant treatment of alcoholism Camila Siqueira Silva, Helio Vannucchi and Guilherme Vannucchi Portari 11. Selenium dietary supplementation and oxidative balance in alcoholism Olimpia Carreras, María Luisa Ojeda and Fatima Nogales 12. Role of zinc in alcoholic liver disease Zhanxiang Zhou 13. Interactions between alcohol and folate Bogdan Cylwik 14. Effects of Acetladehyde on intestinal barrier function D. Jonkers and Elhaseen Elamin 15. Cholesterol regulation by leptin in alcoholic liver disease Balasubramaniyan Vairappan 16. CRF system and alcohol consumption Andrey E. Ryabinin and William J. Giardino 17. Metabolic profiling approaches for biomarkers of ethanol intake Helen G. Gika and Ian D. Wilson Section 3. Genetic machinery and its function 18. Gene expression in alcoholism: an overview Reem Ghazali and Vinood B. Patel 19. Cytochrome P4502E1 Gene Polymorphisms in alcoholics Tao Zeng and K.-Q. Xie 20. Genes associated with alcohol withdrawal Kesheng Wang and Liang Wang 21. Alcohol and epigenetic modulations Claudio D'Addario and Mauro Maccarrone 22. miRNA Expression in the alcoholic liver disease Shashi Bala 22. Alcohol and DNA Methylation Feng C. Zhou 24. Ethanol-mediated carcinogenesis molecular insights as an overview Helmut K. Seitz 25. Molecular link between alcohol and breast cancer: the role of salsolinol Mariko Murata, Kaoru Midorikawa and Shosuke Kawanishi 26. Ethanol impairs Phospholipase D signaling in astrocytes Ute Burkhardt and Jochen Klein 27. Metabolite changes in alcohol gonadotoxicity Ganna M. Shayakhmetova and Larysa B. Bondarenko 28. Hepcidin and iron dysregulation in alcoholics Kosha Mehta and Vinood B. Patel
Dr Vinood B. Patel BSc PhD FRSC is currently a Senior Lecturer in Clinical Biochemistry at the University of Westminster and honorary fellow at King's College London. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the patho-physiology of liver disease. Other areas of interest include identifying new biomarkers that can be used for diagnosis and prognosis of liver disease, understanding mitochondrial oxidative stress in Alzheimers disease and gastrointestinal dysfunction in autism. Dr. Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King's College London in 1997. His post-doctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr. Patel is a nationally and internationally recognized liver researcher and was involved in several NIH funded biomedical grants related to alcoholic liver disease. Dr. Patel has edited biomedical books in the area of nutrition and health prevention, autism, biomarkers, and has published over 150 articles and in 2014 he was elected as a Fellow to The Royal Society of Chemistry.