Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity.
- Accessible and current coverage of coumarin derivatives from structure to potential applications
- Application of SAR technology to predict bioactivity of the derivatives based on its chemical structure
- Information for researchers in medicinal chemistry, pharmaceutical sciences, and related fields
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Chapter 1. Introduction to Coumarin and SAR Chapter 2. Anti-Microbial Agents Chapter 3. Anti-Tumor Agents Chapter 4. Neuroprotective Agents Chapter 5. Anti-depressing agents Chapter 6. Anti-inflammatory Agents Chapter 7. Anti-oxidant agents Chapter 8. Anti-coagulant Agents Chapter 9. Miscellaneous agents
Dr. Santhosh Penta completed his PhD in the field of synthetic organic and heterocyclic chemistry from NIT Warangal with postdoctoral experience with Prof. P. K. Panda, University of Hyderabad, Central University, Hyderabad. Dr. Penta has expertise in the design, synthesis, and, characterization of novel biologically potent nitrogen and sulfur heterocyclic compounds / novel chemical entities by using different methodologies and strategies. Currently during his tenure at NIT-Raipur, he has initiated the research work in multidisciplinary research programs including organic synthesis; and medicinal, combinatorial, and green chemistry, and started to study the biological activity. He is a lifetime member of scientific bodies like the Indian Council of Chemists, The Indian Science Congress Association, Materials Research Society of India, and Indian Chemical Society. Presently, three research scholars are working under his guidance for their PhD.