Hsp90 in Cancer: Beyond the Usual Suspects, Vol 129. Advances in Cancer Research

  • ID: 3429162
  • Book
  • 288 Pages
  • Elsevier Science and Technology
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Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.

- Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins- Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology - Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression

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1. Unusual Suspects in the Twilight Zone between the Hsp90 Interactome and Carcinogenesis
Evangelia Vartholomaiou, Pablo C. Echeverría and Didier Picard
2. Impact of Post-translational Modifications on the Anticancer Activity of Hsp90 Inhibitors
Mark R. Woodford, Diana Dunn, Jonelle B. Miller,Sami Jamal, Len Neckers and Mehdi Mollapour
3. Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
Gaurav Garg, Anuj Khandelwal and Brian S. J. Blagg
4. HSP90 in Cancer:  Transcriptional Roles in the Nucleus
S. K. Calderwood and L. Neckers
5. Hsp90 as a 'Chaperone' of the Epigenome: Insights and Opportunities for Cancer Therapy
Jennifer S. Isaacs
6. Emerging Roles of Extracellular Hsp90 in Cancer
Daniel Senh Wong and Daniel G. Jay
7. GRP94/gp96 in Cancer: Biology, Structure, Immunology and Drug Development
Bill X Wu, Feng Hong, Yongliang Zhang, Ephraim Ansa-Addo and Zihai Li
8. HSP90 and Immune Modulation in Cancer
Michael W. Graner
9. Hsp90: A Global Regulator of the Genotype-To-Phenotype Map in Cancers
Daniel Jarosz
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