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Medicinal Chemistry - Fusion of Traditional and Western Medicine, Edition 3

  • ID: 3429841
  • Book
  • September 2015
  • Bentham Science Publishers Ltd
Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in the various fields of medicinal chemistry, pharmacy, medical and dental programs. Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful. Since, new drugs are being developed by multi-disciplinary teams; this E-Book describes new paradigms that are emerging in modern biology, biochemistry and medicine. It is therefore a fusion of traditional and western medicine and between systems thinking and reductionist thinking.

The 3rd edition attempts to explain the predictive, preventive, personalized and participatory (P4) paradigm of medicinal chemistry. This edition features new chapters focusing on personalized medicinal chemistry and the endocrine system (with a discussion of bioidentical hormone therapy). Other chapters cover the disease mechanism and associated pharmacology of drugs for several diseases including cancer, metabolic syndrome, diabetes, heart disease, stroke, osteoporosis, neurodegenerative diseases, the immune system and much more. The new edition also includes an overview of emergent medical problems and possible solutions (such as the flu, ebola virus, global climate change, a shortage of medicines, genetic engineering and stem cell therapy). Drugs that have been approved by the FDA since the 1st edition was written are also included. The book concludes with an explanation of systems thinking in medicinal chemistry, an important, yet rarely explored topic in other medicinal chemistry text books.
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Foreword

Preface

Conflict Of Interest

Acknowledgements

Dedication

Chapter 1 Personalized Medicinal Chemistry
Introduction
Methods
PCR
Tof-Ms
Next-Generation Sequencing (NGS)
Pharmacogenomics
Effects Of Drugs On Metabolism
Applications
Key Points
Abbreviations
References

Chapter 2 Biology Of Inflammation
Key Points
Abbreviations
References

Chapter 3 Metabolic Syndrome, Diabetes, Heart Disease And Stroke
Glucose And Energy Production
Metabolic Syndrome
Diabetes And Smoldering Inflammation
Treatments And Possible Cures For Diabetes
Peroxisome Proliferator-Activated Receptors, Ppars
Rxr Proteins
Lxr Proteins
Fxr Protein
Constitutive Andostane Receptor (CAR)
Retinoic Acid-Related Orphan Receptor (ROR)
Tak1 Receptor
Treatments For Obesity
Stroke
Myocardial Infarction Or Heart Attack
Preventing And Treatmenting Heart Disease
Key Points
Abbreviations
References

Chapter 4 Biology Of Cancer: Genetics, Biomarkers And Clinical Approaches
Introduction
Angiogenesis
Role Of The Immune System
Diagnosis And Prognosis
Classification For Cancer Development
Causes Of Cancer
The Cell Cycle And Rtks
Role Of Viruses In Causing Cancer
The Role Of The P53 Oncoprotein
Oncogenes And Oncoproteins
Advances In Treating Breast Cancer
Aromatase
Vegf
Pi3K/Akt/Mtor Pathway
Igf-1
Inflammatory Breast Cancer
Early Detection
Lung Cancer
Skin Cancer
Micrornas
Cancer Stem Cells
Telomerase
Mutations In Somatic And Germline Cells
Role Of Cyp450 Enzymes
Cancer Genomics
Cancer Epigenetics
Mutations
Medicinal Chemistry Point Of View
Key Points
Abbreviations:
References

Chapter 5 Medicinal Chemistry And The Endocrine System
Hypothalamus
Pineal Body (Epiphysis)
Pituitary Gland (Hypophysis)
Thyroid
Alimentary Sytem
Kidneys
Adrenal Glands
Reproductive System
The Heart And Skeletal Muscles
Bones And Skeletal System
Calcium Regulation
Targets
Diffuse Neuro-Endocrine System
Major Endocrine Systems
Diseases
Key Points
Abbreviations
References

Chapter 6 Reproductive Medicine, Osteoporosis
Key Points
Abbreviations
References

Chapter 7 The Nervous System
Introduction
Components Of The Nervous System
Neurotransmitters
Neuropeptides
Nitric Oxide And Carbon Monoxide
Glial Cells
Pain Control
Faster Ways To Make Vaccines
Classifying Viruses
Flu (Influenza) Vaccines
Mmr Vaccine The Mmr
Varicella Vaccine
Hepatitis A Vaccines
Dtap Vaccine
Mcv4 Vaccine
Meningitis Vaccines
Human Papilloma Virus Vaccine
Risks To Pharmaceutical Companies
Effort To Develop New Vaccines
Discovering Antigens And Evaluating Cell-Mediated Immune Responses
Advances In Analyzing Immune Responses
Key Points
Abbreviations
References

Chapter 8 The Immune System And Immune Network
Immune Network
Components Of The Immune System
Types Of Immune Cells
Chemical Mediators Of The Immune System
Key Points
Abbreviations
References

Chapter 9 Infectious Diseases
Key Points
Abbreviations
References

Chapter 10 Vaccines
Introduction
Viral Vectors
Cancer Vaccines
Vaccines From Dead Or Inactive Organisms Or Viruses
Childhood Immunizations

Chapter 11 Preventing Diseases By Proper Nutrition
Nutrition
Limits To Usa Recommendations
Risks In Eating Mass-Produced Meat
Fish And Seafood
Other Sources Of Omega-3 And Polyunsaturated Fats
Soybeans And Soy Products
Turmeric
Ginger Root
Antioxidants In Fruits And Vegetables
Fighting Starvation And Malnutrition
Green Revolution
Pollution, Soil Contamination, Ecological Risks And Human Health
Chemical Composition Of Soil And The Changes Involved In The Production Of Crops And Livestock
Genetically-Modified Organisms (Gmos)
Nutrients In Foods
Dietary Supplements
Breast Feeding
Vitamins
Toxicity Of Poorly Chelated Iron
Hazardous Dietary Supplements
Some Of The Most Important And Popular Dietary Supplements
Key Points
Abbreviations
References

Chapter 12 New Problems And Solutions
Emergent Problems
Global Climate Change
Biotechnology-Based Solutions
Nanotechnology
P4 Medicine
Stem Cell Technology
Shortage Of Medicines
Testing For Prostate Specific Antigen
Other Important Recent Discoveries
Recently Approved Drugs
Key Points
Abbreviations
References

Chapter 13 Communication And Signaling In Medicinal Chemistry
Introduction
G Protein-Coupled Receptors
Protein Kinases
Abbreviations
References

Chapter 14 Systems Thinking In Medicinal Chemistry
Systems Biology
Emergent Properties
Systems Thinking
Sinle Cell Technologies
Autopoiesis, Allostasis And Attractors
Gaia
Networks
Networks In Aging As Well As Neurodegenerative And Psychiatric Diseases
Network Analysis Of Mother’S Milk
Conclusion
Key Points
Abbreviations
References

Appendix

Subject Index
Drugs To Help People Stop Smoking [1]
Drugs That Treat Neurodegenerative Diseases
Inflammatory Cytokines
Parkinson’S Disease
Alzheimer’S Disease
Epilepsy
Anxiety Disorders
Depression
Antipsychotics
Autism
Amyotrophic Lateral Sclerosis (Als) [1]
Damaged Spinal Cords
Medicinal Chemistry Point Of View
Key Points
Abbreviations
References
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