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Frontiers in Antimicrobial Agents Vol. 1

  • ID: 3508520
  • Book
  • December 2015
  • Bentham Science Publishers Ltd
The addition of only two novel classes of antibiotics to fight drug resistant microorganisms in the clinic over the past three decades means that the quest for new molecules that are effective against the threat of drug resistance is now a significant issue in modern medicine. Researchers have begun to experiment on alternative therapies to combat this threat.

Novel chemical agents are considered to be drugs of choice for tomorrow's clinical practice owing to their low probability to generate resistance. The first volume of Frontiers in Antimicrobial Agents describes innovative alternatives to the classical antimicrobial therapeutics, such as phage therapy, AMPs, probiotics, novel biocides, natural products and immunotherapy. Cutting-edge research is brought to the forefront, shedding light on the developments taking place to meet the challenge of drug resistant microorganisms. The volume also features information on antimicrobial approaches in veterinary medicine.

The book is a useful reference for researchers, microbiologists and healthcare professionals interested in updates on antibiotic resistance and alternatives to classical antibiotic therapy.
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List Of Contributors

Chapter 1 Introduction
Conflict Of Interest
Acknowledgements
References

Chapter 2 Bacteriophages As Antibacterial Agents: Why Are We Facing An Antibiotic Crisis And How Could Bacteriophages Be Of Help?
1. Introduction
2. Why Are We Facing An Antibiotic (Ab) Crisis?
3. How To Resolve This Antibiotic Crisis?
4. Bacteriophages Or In Short ‘Phages’
5. Bacteriophage Therapy Or Phage Therapy
6. Experimental Phage Therapy
7. Safety Issues
8. In Fact We Live In An “Ocean” Of Bacteriophages
9. Safety Requirements For Phage Therapy
10. The Potential Advantages Of Phage Therapy Versus Antibiotics
11. Phage Therapy In Public Health
12. Why Phage Therapy Is Not Yet Implemented?
Conclusions And Perspectives
Conflict Of Interest
Acknowledgements
References

Chapter 3 Antimicrobial Peptides
Introduction
1. What Are Antimicrobial Peptides (Amps)
1.1. Mode Of Action
1.2. Immune System
1.3. Resistance
2. Chronology Of Amps Discovery – A Brief History
2.1. Classification Of Amps
2.1.1. Biological Source
2.1.2. Biological Functions
2.1.3. Biosynthesis
2.1.4. Molecular Properties
2.1.5. Molecular Targets
2.1.6. Three-Dimensional (3D) Structure
2.2. Currently Active Amps Databases
3. Therapeutic Applications Of Amps
3.1. Anticancer Amps
3.2. Antiviral Amps
3.3. Anti-Parasitic Amps
3.4. New Generation Of Amps
Concluding Remarks
Conflict Of Interest
Acknowledgements
References
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