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Impact of Genome Editing Techniques

  • ID: 3532986
  • Report
  • Region: Global
  • 72 Pages
  • Frost & Sullivan
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Breakthrough Innovations Across Agriculture and Human Therapeutics
Improvements and new gene editing techniques are constantly that have a high disruptive and revolutionary impact within the application for healthcare and other verticals. Accurate and highly precise manners of manipulating genetic content has not been present until the recent developments across the space of gene editing techniques. These tools, that have been developed can effectively provide researchers with the capacity to understand disease and potentially cure it. It also has the potential to impact the production rate and quality of agricultural and livestock products.

Recent developments across genome editing technologies have resulted in the creation of next generation nucleases, that have higher levels of accuracy when correcting genetic mutations and defects. The classes under the genome editing technologies are the 4 broad families of nucleases: ZFNs, TALENs, CRISPR/Cas9, and Meganucleases. Though there are non-nuclease-based approaches and various proprietary gene editing techniques, the industry favorites are still the nuclease-based approaches.

Gene editing technologies have an impact across multiple applications areas including plant and animal genetic engineering. However, the area of most disruption is across human cell line engineering, which enables the development of next generations therapies and drugs. However, the agricultural industry has seen more success with gene editing techniques largely due to the less stringent regulatory environment.

From a regional standpoint, the United States of America, has currently contributed the most toward the development of these unique and highly beneficial techniques. While Europe and Asia are closely following with increased investments entering these regions through partnership agreements.

This research service brings out the impact of gene editing techniques on a global scale, through a detailed strategic assessment of the industry environment, including:

- Technology overview and comparison of technological capabilities between various gene editing techniques.
- Impact of gene editing across multiple applications areas such as agriculture, cosmetics, human therapeutics, animal models and livestock cultivation.
- Industry best practices and strategic insights, measuring performance, assessment of partnerships and alliances as well as detailed company profiles and breakthrough innovations.
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1. Executive Summary

2. Sneak Peak - Gene editing
  • Where does gene editing stand today?
  • Segmentation - Application Overview
  • Segmentation - Technology overview
3. Technology Overview
  • Main technology areas of focus enabling gene editing
  • Other technologies enabling gene editing
  • Technology capability
  • Technology capability : Comparative assessment
  • Approach : Technology Readiness Level (TRL)
  • TRL: ZFNs
  • TRL: TALENs
  • TRL: CRISPR/Cas9
4. Industry Initiatives and Market Impact
  • Market Impact of Technology/Business Accelerators
  • Market Impact of Technology/Business Challenges
  • Innovation Ecosystem: Key Innovators
  • Agriculture - Plant-based applications
  • Player assessment across application
  • Breakthrough’s using gene editing technologies
  • Industrial bio-based applications
  • Player assessment across application
  • Breakthrough’s using gene editing technologies
  • Gene edited animal-based applications
  • Player assessment across application
  • Breakthrough’s using gene editing technologies
  • Human therapeutics applications
  • Player assessment across application
  • Utilization of Gene editing
  • Breakthrough’s using gene editing technologies
  • Breakthrough’s using gene editing technologies
  • Stakeholder Assessment
  • Partnership Assessment
5. Opportunity Assessment and Technology Roadmap
  • Approach - Company Profile
  • Editas Medicine
  • Intellia Therapeutics
  • CRISPR Therapeutics
  • Caribou
  • Regulatory Landscape
  • Geographic Assessment
  • Technology Roadmap
6. Patent Analysis
  • Patent search Scope
  • Patent Publishing Trends, Global, 2010 - 15*
  • Top 20 Patent holders, Global, 2010- 15*
  • Patents per Source Jurisdiction (Top 10 Patent offices), Global, 2010 - 15*
7. Key Contacts
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Gene editing technologies are promising a radical change across the biotechnology community. Every instance when the medical and research community discovered a potentially radical technology that could revolutionize the development of therapeutics, it has resulted in the awakening of the entire stakeholder value chain. This usually leads to the establishment of multi-billion dollar franchise that comprises of venture capitals, biotechnology start-ups, numerous collaborations between university and industry participants. The role of gene editing has been vital across multiple domain areas such as agriculture, veterinary sciences, and also human health and therapeutic research and development. Recently, there has been significant speculation on the ethical and social implications of using certain gene editing techniques like the simple, yet effective CRISPR approach.

Owing to the developments and high level of speculation, as well as large the avid support for and against the utilization of gene editing techniques, an international summit on gene editing was conducted by the National Academies in the United States of America. This event saw the presence of other major national academics, the Royal Society of London and the Chinese Academy of Sciences. The entire summit was spent discussing the progress as well as the future impact that these technologies would have in human health. It culminated with the motivation to move forward in using these techniques, however, with proper regulatory frameworks as well as a holding off on the clinical use of gene editing for germline manipulation.
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