Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment.
With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.
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Section I. Overview of Neuro-Oncological Disorders 1. Overview of Brain Tumor Epidemiology 2. Overview of Pathology and Treatment of Primary Brain Tumors 3. Overview of Pathology and Treatment of Metastatic Brain Tumors 4. Overview of Spinal Cord Tumor Epidemiology 5. Overview of Pathology and Treatment of Primary Spinal Cord Tumors 6. Overview of Pathology and Treatment of Intramedullary Spinal Cord Metastases 7. Epidural Spinal Cord Compression in Adult Neoplasms 8. Neoplastic Meningitis 9. Vascular Disorders: Epidemiology 10. Intracranial Hemorrhage in Cancer Patients 11. CNS Infarction 12. Intracranial Veno-Occlusive Disease 13. Paraneoplastic Syndromes 14. Neoplastic Plexopathies 15. Neurologic Complications of Oncologic Therapy Section II. Physics and Basic Science of Neuro-Imaging 16. Physics of CT: Scanning 17. Physics of CT: Contrast Agents 18. Introductory MRI Physics 19. Advanced MR Imaging of Brain Tumors 20. MR Contrast Agents for Neuroradiology: Current Status 21. Physics of High Field MRI and Applications to Brain Tumor Imaging Section III. Advances in Neuro-Imaging of Brain Tumors 22. Magnetic Resonance Image Guided Neurosurgery 23. Neurosurgical Treatment Planning 24. Use of Neuro-Imaging for Radiation Therapy Planning 25. TTFields Therapy: Preclinical and Clinical Data 26. Applications of Stereotactic Radiosurgery in Neuro-Oncology 27. Diffusion Magnetic Resonance Imaging in Brain Tumors 28. Diffusion Imaging of Brain Tumors 29. Functional MRI 30. Magnetic Resonance Spectroscopy 31. Perfusion Imaging for Brain Tumor Characterization and Assessment of Treatment Response 32. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Physics 33. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Imaging 34. Methionine PET
Overview and Application to Brain Tumor Imaging and Treatment 35. Ultra-High Field Magnetic Resonance Imaging of Brain Tumors 36. Neuroimaging of Brain Tumors in Animal Models of CNS Cancer 37. RANO Criteria: Application to Response Assessment in Clinical Trials Section IV. Neuro-Imaging of Brain Tumors 38. Malignant Astrocytomas 39. Low Grade Astrocytomas 40. Imaging of Oligodendrogliomas 41. Primary Central Nervous System Lymphoma 42. Pituitary and Sellar region Lesions 43. Neoplasms of the Cranial Nerves 44. Meningeal tumors 45. Intracranial Schwannomas 46. Diencephalic and other deep brain tumors 47. Neuro-Imaging of Glioneuronal Tumors 48. Pineal region tumors 49. Chordomas and other skull base tumors 50. Pediatric brain tumors 51. Papillary Glioneuronal Tumors 52. Intracranial Metastases 53. Non-Neoplastic mass lesions of the CNS 54. Neuroimaging Issues in Assessing Response to Brain Tumor Therapy 55. Pseudoprogression in Neuro-Oncology: Overview, Pathophysiology, and Interpretation 56. Pitfalls in the Neuroimaging of Brain Tumors Section V. Neuro-Imaging of Other Neuro-Oncological Syndromes 57. Neuroradiology of Leptomeningeal Metastases 58. Imaging of Epidural Spinal Cord Compression 59. Neuro-imaging for Surgical Treatment Planning of Neoplastic Disease of the Spine 60. Imaging of Plexopathy in Oncologic Patients 61. Imaging of Peripheral Neurogenic Tumors 62. Neuro-Imaging of Cerebrovascular Complications in Cancer Patients 63. Neuroimaging of Paraneoplastic Syndromes
Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years.