Pediatric Brain Stimulation: Mapping and Modulating the Developing Brain presents the latest on this rapidly expanding field that has seen an exponential growth in publications over the past 10 years. Non-invasive modalities like TMS can painlessly map and measure complex neurophysiology in real patients. Neuromodulatory applications like rTMS and tDCS carry increasingly proven therapeutic applications. Rapidly advancing technological methodologies are increasing opportunities and indications.
Despite all these benefits, applications in the more plastic developing brains of children are only just emerging. This book provides a comprehensive overview of brain stimulation in children. Chapters include Transcranial Magnetic Stimulation (TMS) fundamentals, brain stimulation in pediatric neurological conditions, and invasive brain stimulation.
The main audience for this research will be those interested in applying brain stimulation technologies to advance clinical research and patient care, although a wide variety of clinicians and scientist will find this to be a valuable reference on brain stimulation with specific chapters on a variety of conditions.
- Provides an overview of recent findings and knowledge of pediatric brain stimulation and the developing brain
- Edited by renowned leaders in the field of pediatric brain stimulation
- Presents a great resource for basic and clinical scientists and practitioners in neuroscience, neurology, neurosurgery, and psychiatry
1. TMS basics: Single and paired pulse neurophysiology
Ephrem Zewdie and Adam Kirton
2. Assessing normal developmental neurobiology with brain stimulation
Karina Limburg, Nikolai H. Jung and Volker Mall
3. Neuroplasticity Protocols: Inducing and measuring change
Steve W. Wu and Ernest V. Pedapati
4. Therapeutic rTMS in children
Donald L. Gilbert
5. Transcranial direct current stimulation (tDCS): Principles and emerging applications in children
Adam Kirton and Patrick Ciechanski
6. Insights into pediatric brain stimulation protocols from preclinical research
7. Pediatric issues in neuromodulation: Safety, tolerability and ethical considerations
Kathleen M. Friel, Andrew M. Gordon, Jason B. Carmel, Adam Kirton and Bernadette Gillick
Section II: NIBS IN PEDIATRIC NEUROLOGICAL CONDITIONS
8. TMS applications in ADHD and developmental disorders
Donald L. Gilbert
9. TMS mapping of motor development after perinatal brain injury
10. The right stimulation of the right circuits: Merging understanding of brain stimulation mechanisms and systems neuroscience for effective neuromodulation in children
Jason B. Carmel and Kathleen M. Friel
11. Therapeutic brain stimulation trials in children with cerebral palsy
Bernadette Gillick, Kathleen Friel, Jeremiah Menk and Kyle Rudser
12. Brain Stimulation in Children Born Preterm
Promises and Pitfalls
Julia B. Pitcher
13. Brain stimulation to understand and modulate the autism spectrum
Lindsay M. Oberman, Alvaro Pascual-Leone and Alexander Rotenberg
14. Clinical applications of brain stimulation in pediatric epilepsy
15. Brain stimulation in pediatric depression: Biological mechanisms
Paul Croarkin, Stephanie Ameis and Frank P. MacMaster
16. Brain stimulation in childhood mental health: Therapeutic applications
Frank P. MacMaster, Mariko Sembo, Keon Ma and Paul Croarkin
17. Transcranial Magnetic Stimulation Neurophysiology of Paediatric Traumatic Brain Injury
Karen Maria Barlow and Trevor Adam Seeger
18. Brain Stimulation Applications in Pediatric Headache and Pain Disorders
Thilinie Rajapakse and Adam Kirton
Section III: INVASIVE BRAIN STIMULATION IN CHILDREN
19. Deep brain stimulation in children: Clinical considerations
20. Deep brain stimulation in children: Surgical considerations
21. Invasive neuromodulation in pediatric epilepsy: VNS and emerging technologies
Manish Ranjan and Walter Hader
22. Emerging Applications and Future Directions in Pediatric Neurostimulation
Donald L. Gilbert and Adam Kirton
Dr. Kirton is an attending Pediatric Neurologist at the Alberta Children's Hospital and Associate Professor of Pediatrics and Clinical Neurosciences at the University of Calgary. His research focuses on perinatal stroke with two major aims. One is to understand why such strokes occur and develop means to prevent them. The other uses advanced technologies including neuroimaging and non-invasive brain stimulation to measure the response of the developing brain to early injury and generate new therapies. Dr. Kirton is a Heart and Stroke Foundation Clinician Scientist and received CIHR Foundations funding in 2015. He founded and directs the Calgary Pediatric Stroke Program, Alberta Perinatal Stroke Project, and ACH Pediatric Non-Invasive Brain Stimulation Laboratory.
Gilbert, Donald L.
Donald Gilbert, MD, earned his Bachelor of Arts at Princeton University, where he majored in philosophy. He subsequently earned his MD at the University of Michigan and spent a year at the National Institutes of Health as a Howard Hughes Medical Institute Research Scholar. Dr. Gilbert did his pediatrics and neurology training at John Hopkins in Baltimore and is board certified in neurology with special competence in child neurology. Dr. Gilbert has an MS in clinical research design and statistical analysis from the University of Michigan.
At Cincinnati Children's, Dr. Gilbert directs the Movement Disorders and Tourette's Syndrome Clinics, which specialize in evaluation and pharmacologic treatment of tics, chorea, tremor, dystonia, stereotypies, ataxia, and other movement disorders http://www.cincinnatichildrens.org/service/m/movement/default/. Dr. Gilbert directs or participates in a number of single and multi-center studies into causes and treatments of Tourette's syndrome. Dr. Gilbert also does research into cortical inhibition and neuroplasticity mechanisms in childhood at the Transcranial Magnetic Stimulation Laboratory http://www.cincinnatichildrens.org/research/divisions/n/neurology/labs/gilbert-wu/research/ at Cincinnati Children's.