Knock out Mouse Model- Pricing Analysis, [by Indication, Mouse type, End users, Discounting, Corporate Agreements, Economic Model of Demand and Supply, Physiological Characteristics, Business Models, and Stakeholder Analysis]

  • ID: 3624692
  • Report
  • Region: Global
  • 57 Pages
  • Markets and Markets
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Mice Models Are Indispensable Tools in Research Activities With their Capability to Elucidate Human Disease Processes

FEATURED COMPANIES

  • Taconic Biosciences, Inc.
  • The Jackson Laboratory
  • MORE
Knockout mice models are of paramount importance in biomedical researches which focus on finding cure for human diseases. Extensive research on the knock-out mice model market has brought to light that knock-out mice models are available with a broad price range and there are many factors that impact the pricing of knockout mice. The factors having high impact on the pricing trend have been grouped under pivotal factors and the lesser impacting factors have been categorised as other factors.
Price of Knock-out mice models varies from USD 2,000 to USD 10, 0000. Below is the list of some of the factors affecting pricing of knock-out mice models -

PIVOTAL FACTORS:
? Indications
For instance, the high popularity and easy availability of mice models for diseases like cancer, diabetes, and cardiovascular diseases translates into relatively lower prices of these models as compared to knockout mice models that address indications such as neurological disorders and rare diseases.

? Type of knock-out mice
For instance, high complexity in the development of conditional knockouts makes them expensive than constitutive and double knockout models.

? Agreements
For instance, the price is high in case the agreements are for commercial purposes and low if the agreements are for a non-commercial and non-profit purpose.

? Discounts
For instance, companies offer a range of discounts such as bulk discounts, seasonal discounts, and discounts on full upfront payments that leads to the variation in the final the price of the models.

OTHER FACTORS:

? Demand & Supply
For instance, the high demand for some models translates into strong sales, thereby enabling the sellers to reach Break Even Point (BEP) earlier which in turn allows them to recover the cost of development. This factor plays a crucial role in reducing the price of knockout mice models which are in high demand

? End users
For instance, Costs are relatively higher for commercial end users such as pharmaceutical companies, biotechnology companies, and non-profit organizations affiliated with a for-profit entity

? Physiological factors
These factors include age, weight (in case of obesity models) For instance, as the mice age their cost increases. This is attributed to the increase in the expenditure for housing and looking after the mice. Moreover, the welfare monitoring of old mice is more complex than that of young mice, since it is difficult to differentiate between signs of ageing and signs of ill health in old mice

Reasons to Buy the Report:
The report will enrich both established firms as well as new entrants/smaller firms to gauge the price variation of knock-out mice models. Pricing assessment of knock-out mice models would help stakeholders in the market to align or re-align their business strategies with respect to pricing of these models. Appropriate pricing of these models is likely to translate into greater revenue share and customer base for the stakeholders in the market.
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FEATURED COMPANIES

  • Taconic Biosciences, Inc.
  • The Jackson Laboratory
  • MORE
1 Introduction
1.1 Scope of the Study
1.2 Factors Affecting Cost of Knockout Mice

2 Indications
2.1 Commonly Available Knockout Mice Cost Less
2.2 Cost of Knockout Mice Models for Other Disorders Relatively High
2.3 Cancer Knockout Mice Models Priced Lower
2.4 Rare Diseases Driving Demand for Customized Models
2.5 Price Tables for Non-Obese Diabetic (NOD) Scid Mice, By Company
2.5.1 The Jackson Laboratory
2.5.2 Harlan Laboratories (Now Part of Envigo)
2.5.3 Charles River Laboratories, Inc.
2.5.4 Taconic Biosciences, Inc.
2.6 Price Variation of Non-Obese Diabetic Mice (Non Scid), By Company

3 Types of Knockout Mice
3.1 Price of Knockout Mice, By Type (2-In-1, Constitutive, Conditional, Cluster)
3.2 Conditional Knockouts Highly Complex and Priced High
3.3 Customized Knockout Can Cost Up to Usd 100,000

4 Economic Model of Demand & Supply
4.1 Mice Models for Autism, Schizophrenia, Alzheimer’s Gaining Popularity

5 Agreements
5.1 Agreements Impact Cost of Knockout Mice Models
5.2 Price Determination Illustration in A Business Segment
5.3 Illustrative Examples

6 Discounts
6.1 Bulk, Seasonal and Other Discounts Impact Pricing

7 Physiological Characteristics
7.1 Price Variation for Obesity (C57bl6) Mice Models, By Weight, Sex and Age

8 End Users
8.1 Commercial Customers Charged Higher Than Non-Profits

9 Business Models
9.1 Technology Licensing
9.2 Co-Distribution Through Partnerships/Agreements
9.3 Independent Commercial Production

10 Stakeholders
10.1 Key Stakeholders for Mass Produce and Customized Mice Models
10.2 Indicative List of Buying Companies and Universities

11 Appendix
11.1 Selected References
11.2 Related Reports
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FEATURED COMPANIES

  • Taconic Biosciences, Inc.
  • The Jackson Laboratory
  • MORE
Mice serve as appropriate study models for a variety of diseases because of their close genetic and physiological similarities to humans as well as the ease with which their genomes can be manipulated and analyzed. Knockout mice models are of paramount importance in biomedical researches which focus on finding cure for human diseases.

Market players are continuously focusing on innovations in mice models for research on various human diseases. Growing innovations and advances in mice models are providing increased options to researchers to conduct research activities in particular diseases, which is a major factor driving market growth.

Oncology knockout mice are in high demand, owing to the increasing number of cancer research activities and increasing innovation in mice models that are tailored to meet cancer research needs. Thus, the popularity and availability of cancer knockout mice has led to reduction in the cost of these models. In the present scenario, the availability of knockout mice models for rare diseases is low and the cost of these models is relatively higher as compared to knockout mice models for common indications such as cancer, cardiovascular diseases, and diabetes.

In addition, the type of the knock-out mice developed determines the complexity of the project and thus, the price of the knock-out mice model. Development of Cluster Knockout is highly complex as it involves knocking out of many genes at once. Thus the price of cluster knockout is higher than other types of knockout.

The demand & supply status of the knock-out mice also affect the pricing trend. For instance, Knockout mice models for cancer, cardiovascular diseases, neurological disorders, and diabetes are well-established, available in sufficient supply, and priced lower than the knockout mice models that address indications such as neurological disorders and rare diseases. Knockout models for rare diseases are in low supply as research in these fields is yet to gain momentum. With a steady increase in research activities and low supply of knockout models for these indications, the demand for customized knockout mice for these indications is likely to grow, thus leading to their high price.

The price also depends upon the type of agreements within the research organizations. The price is high in case the agreements are for commercial purposes and low if the agreements are for a non-commercial and non-profit purpose.

Similarly, some other factors like physiological characteristics, discounts, end users, among others affect the pricing range of the knock-out mice models.

Exteneded Description

Mice models are the most popularly used animal models due to their small size, short generation time, accelerated lifespan, low cost, and requirement of less space. These factors help in accelerating the research and development of drug therapies.

Knockout mice are produced by inactivating/silencing or "knocking out" an existing gene and replacing it with an artificial piece of DNA, thereby resulting in the loss of gene activity. This leads to changes in the mouse's phenotypic characteristics, such as appearance, behavior, and other observable biochemical characteristics.

Different research areas that widely use knockout/ knock-in mice include studying and modeling different types of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging, and Parkinson’s disease, among others.

Apart from rampant use of knockout/ knock-in mice in diverse research areas, continuous introduction of new models coupled with signing of various licensing agreements that adds to the widened usage of the models is providing impetus for growth of this market.

Clinical Research Organizations (CROs), Mice Model and Services Distributors, Academic Institutes, Government and Private Research Institutes, and Medical Research Centers are some of the are some of the key stakeholders who are likely to benefit from the pricing assessment of knock-out mice. The report will enrich both established firms as well as new entrants/smaller firms to gauge the price variation of knock-out mice models.

Pricing assessment of knock-out mice models would help stakeholders in the market to align or re-align their business strategies with respect to pricing of these models. Appropriate pricing of these models is likely to translate into greater revenue share and customer base for the stakeholders in the market.

Scope of the Report

This report provides pricing assessment of the knock-out mice models in terms of indications, type, physiological characteristics, end users, economic model, business model, stakeholders, agreements, and discounts.

Introduction

- Scope of the study
- Factors affecting cost of knock-out mice

Indications

- Commonly available knockout mice cost less
- Cost of knockout mice models for other disorders relatively high
- Cancer knockout mice models priced lower
- Rare diseases driving demand for customized models
- Price tables for non-obese diabetic (nod) SCID mice, by company
-- The Jackson Laboratory
-- Harlan Laboratories (Now part of Envigo)
-- Charles River Laboratories, Inc.
-- Taconic Biosciences, Inc.
- Price variation of non-obese diabetic mice (NON SCID), by company

Types of Knockout Mice

- Price of knockout mice, by type (2-in-1, constitutive, conditional, cluster)
- Conditional knockouts highly complex and priced high
- Customized knockout can cost up to USD 100,000

Economic Model of Demand & Supply

- Mice models for autism, schizophrenia, Alzheimer’s gaining popularity

Agreements

- Agreements impact cost of knockout mice models
- Price determination illustration in a business segment
- Illustrative examples

Discounts

- Bulk, seasonal and other discounts impact pricing

Physiological Characteristics

- Price variation for obesity (c57bl6) mice models, by weight, sex and age

End Users

- Commercial customers charged higher than non-profits

Business Models

- Technology licensing
- Co-distribution through partnerships/agreements
- Independent commercial production

Stakeholders

- Key stakeholders for mass produce and customized mice models
- Indicative list of buying companies and universities
Note: Product cover images may vary from those shown
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- Charles River Laboratories, Inc.
- Harlan Laboratories (Now Part of Envigo)
- Taconic Biosciences, Inc.
- The Jackson Laboratory
Note: Product cover images may vary from those shown
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Note: Product cover images may vary from those shown
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