No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations.
In this embattled terrain, the most we can hope for from the biomaterials we design is a type of "meso-compatibility,? a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction.
- Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death- Brings together the two fields of biomaterials and the biology of oxidative stress- Provides approaches for the design of biomaterials with improved biocompatibility
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Chapter 1. Free Radical Chemistry Primer
Chapter 2. Oxidative stress, Inflammation and Disease
Chapter 3. Biomaterial Biocompatibility: Current Understanding and Basics
Chapter 4. Oxidative Stress and Biomaterials: The Inflammatory Link
Chapter 5. Nanoparticle Toxicity and Environmental Impact
Section II. Analytical Tools
Chapter 6. In Vitro -Cell Free Systems for Oxidative stress analysis
Chapter 7. In Vitro- Cellular Assay for Oxidative stress and Biomaterial Response
Chapter 8. In Vivo Assays for Oxidative stress and Biomaterial Biocompatibility
Chapter 9. Emerging Technologies and needs in Oxidative stress analysis
Section III. Incorporating Oxidative Stress into Biomaterial Design
Chapter 10. Oxidation State as a Bioresponsive Trigger
Chapter 11. Antioxidant Polymers as a Biomaterial or Therapeutic choice
Chapter 12. Metal Nanoparticle Antioxidants
Chapter 13. Oxidative Stress and Cancer Therapy
Chapter 14. Immunomodulatory Biomaterials
Dr. Thomas Dziubla, Ph.D. is the Associate Gill Professor and Director of Graduate Studies in the Department of Chemical and Materials Engineering at the University of Kentucky. He received his B.S. and Ph.D in Chemical Engineering from Purdue University (1998) and Drexel University (2002), respectively. In 2002-2004, he was an NRSA postdoctoral fellow in the Institute for Environmental Medicine at the University of Pennsylvania's School of Medicine under the guidance of Dr. Vladimir Muzykantov, where he worked on the design of degradable polymeric nanocarriers for the delivery of antioxidants. His research group is interested in the design of new functional polymeric biomaterials, which can actively control local cellular oxidative stress for improved biomaterial integration and disease treatment. Dr. Dziubla is a member of Society for Biomaterials and American Institute of Chemical Engineers. He holds 8 patents, has authored over 50 peer reviewed publications and has started several companies that are currently commercializing technologies that have originated from his laboratory.
Butterfield, D Allan
Professor, Department of Chemistry and Faculty Associate, Sanders-Brown Center on Aging, University of Kentucky. Also holds the position of Director, Center of Membrane Sciences and Free Radical Biology in Cancer Shared Resources. Professor since 1975 and has co-authored more than 500 articles in Bio-chemistry.