Nanomaterials are able to penetrate nanoscale pores of tissues, possess prolonged circulation, enter cells, and have increased surface area per volume allowing for greater drug loading. For these reasons, nanomaterials are finding numerous uses in medicine including fighting cancer, promoting tissue regeneration, reversing aging, inhibiting infection, limiting inflammation or scar tissue growth, and many others.
This book describes the engineering applications and challenges of using nanostructured surfaces and nanomaterials in healthcare. Topics covered include biomimetic coating of calcium phosphates on Ti metals; surface modifications of orthopedic implant materials using an electroplating process; design, fabrication and application of carbon-based nano biomaterials; usage of stem cells in bone and cartilage tissue engineering; nanobiomaterials and 3D bioprinting for osteochondral regeneration; self- assembled peptide hydrogels for biomedical applications; antimicrobial properties of nanomaterials; nanoparticle enhanced radiation therapy for bacterial infection; nanomaterials used in implant technology and their toxicity; challenges of risk assessment of nanomaterials in consumer products and current regulatory status; and the clinical rationale for silicon nitride bioceramics in orthopedics.
With contributions from an international selection of researchers this book is essential reading for researchers in industry and academia working at the interfaces of healthcare, engineering and nanotechnology.
- Chapter 1: Biomimetic coating of calcium phosphates on titanium alloys
- Chapter 2: Surface modifications of orthopedic implant materials using an electroplating process
- Chapter 3: Carbon-based nano biomaterials: design, fabrication and application
- Part II: Nanomaterials for soft tissue engineering
- Chapter 4: Usage of stem cells in bone and cartilage tissue engineering
- Chapter 5: Nanobiomaterials and 3D bioprinting for osteochondral regeneration
- Chapter 6: Self-assembling peptide hydrogels for biomedical applications
- Part III: Nanomaterials for bacterial infections and their toxicity
- Chapter 7: Antimicrobial properties of nanomaterials
- Chapter 8: Nanoparticle-enhanced radiation killing of bacteria
- Chapter 9: Conventional and nano-based approaches to prevent bacterial infection
- Chapter 10: Nanomaterials used in implant technology and their toxicity
- Part IV: Current and future clinical applications of nanomaterails
- Chapter 11: Nanotechnology and consumer products: challenges of risk assessment of nanomaterials and current regulatory status
- Chapter 12: The scientific rationale for using silicon nitride in biomedical implants
Northeastern University in Boston, USA.
Thomas Webster is the Department Chair and Professor of Chemical Engineering at Northeastern University in Boston, USA. His research explores the use of nanotechnology in numerous applications. He is the President of the Society of Biomaterials, founding editor-in-chief of the International Journal of Nanomedicine, and serves on the editorial board of 15 additional journals. He has helped to organize 22 conferences emphasizing nanotechnology in medicine, and has organised over 53 symposia at numerous conferences emphasizing biological interactions with nanomaterials for AIChE, IEEE, MRS and ASME Annual Meetings.Hilal Yazici Senior Researcher.
TUBITAK - GEBI, Turkey.
Hilal Yazici is currently Senior Researcher at TUBITAK (The Scientific and Technological Research Council of Turkey)-GEBI. Previously, she was a postdoctoral research associate in Professor Thomas Webster's Group at Northeastern University. She also worked as researcher at various universities including University of Washington, University of Potsdam and Technical University of Berlin. She received her MSc and PhD from Istanbul Technical University in 2005 and 2012 respectively. Her research interests are molecular biomimetics, material binding peptides, biological coating of biomaterials and protein-enabled biosensors. She has authored over 50 peer reviewed journal papers, conference proceedings and presentations.