Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies.
This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.
- Provides a comprehensive introduction to collagen and structural proteins
- Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation
- Includes a chapter dedicated to the biomarkers of structural proteins
- Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states
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Chapter 1. Type I Collagen
Chapter 2. Type II Collagen
Chapter 3. Type III Collagen
Chapter 4. Type IV Collagen
Chapter 5. Type V Collagen
Chapter 6. Type VI Collagen
Chapter 7. Type VII Collagen
Chapter 8. Type VIII Collagen
Chapter 9. Type IX Collagen
Chapter 10. Type X Collagen
Chapter 11. Type XI Collagen
Chapter 12. Type XII Collagen
Chapter 13. Type XIII Collagen
Chapter 14. Type XIV Collagen
Chapter 15. Type XV Collagen
Chapter 16. Type XVI Collagen
Chapter 17. Type XVII Collagen
Chapter 18. Type XVIII Collagen
Chapter 19. Type XIX Collagen
Chapter 20. Type XX Collagen
Chapter 21. Type XXI Collagen
Chapter 22. Type XXII Collagen
Chapter 23. Type XXIII Collagen
Chapter 24. Type XXIV Collagen
Chapter 25. Type XXV Collagen
Chapter 26. Type XXVI Collagen
Chapter 27. Type XXVII Collagen
Chapter 28. Type XXVIII Collagen
Chapter 29. Laminins
Chapter 30. Elastin
Chapter 31. Structural Biomarkers
Morten Karsdal has been CEO of Nordic Bioscience A/S since June 2010.
Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.