Preneoplasia of the Breast. A New Conceptual Approach to Proliferative Breast Disease

  • ID: 3687888
  • Book
  • 608 Pages
  • Elsevier Health Science
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Safe and accurate preoperative diagnosis of breast lesions is crucial to spare patients unnecessary, disfiguring operations.

Prenoeoplasia of the Breast covers the clinical, radiological and histological diagnosis of benign proliferative breast disease and precursor lesions of breast cancer.

It focuses on a new immunohistochemical method based on an innovative progenitor cell concept of breast epithelium that has been developed by Prof. Boecker, Prof. Schnitt and Prof. Silverstein. This technique can also be used for small samples (percutaneous core biopsy) and offers high specificity, and therefore provides a greater degree of diagnostic security.

The practical applicability and interpretation of the technique are integrated into a comprehensive description of all benign and malignant noninvasive proliferative diseases of the breast, including:

. Interpretation of histologic samples attained by stereotactic biopsy (including immunohistochemistry)
. Comparison of radiologic and pathologic findings
. Action to be taken in the case of in-situ malignoma
. Treatment of DICS
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Chapter 1: The Normal breast

Chapter 2: Fibrocystic change and miscellaneous "non-neoplastic" epithelial and stromal lesion

Chapter 3: Metaplastic changes and their neoplastic counterparts

Chapter 4: Percutaneous breast biopsy

Chapter 5: Pathological diagnosis in minimal invasive biopsy

Chapter 6: Pathological diagnosis in surgical specimens

Chapter 7: Basic principles of benign proliferative breast disease

Chapter 8: Usual ductal hyperplasia

Chapter 9: Sclerosing adenosis and other forms of adenosis

Chapter 10: Radial scar

Chapter 11: Papilloma

Chapter 12: Adenoma of the breast and variants

Chapter 13: Adenoma of the nipple

Chapter 14: Adenomyoepithelial tumors

Chapter 15: Fibroepithelial tumors

Chapter 16: Inflammatory conditions of the breast

Chapter 17: Basic principles of precursor lesions of breast cancer

Chapter 18: Flat epithelial atypia

Chapter 19: Atypical ductal hyperplasia

Chapter 20: Ductal carcinoma in situ

Chapter 21: Lobular neoplasia

Chapter 22: The cytology of preneoplastic disease

Chapter 23: Hormonal and genetic risk factors

Chapter 24: Treatment for patients with ductal carcinoma in situ

Chapter 25: Risk adapted therapy of ductal carcinoma in situ

Chapter 26: Cytogenetic concepts of intraductal proliferative breast disease and invasive breast cancer

Chapter 27: Pleiotropic functions of eht erbB oncogene family in breast cancer development and progression
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Böcker, Werner
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