With the most comprehensive and up–to–date overview of structure–based drug discovery and using experimental and computational approaches,Structural Biology in Drug Discovery: Methods, Techniques, and Practices covers principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a fast–growing field.
The combined chapters, by authors writing from the frontlines of structural biology and drug research, give readers a valuable reference and resource that:
Presents the benefits, limitations, and potentiality of novel techniques in the field, like complex crystallization, X–ray diffraction, NMR, mass spectrometry, and computational chemistry
Assesses macromolecular structures with experimental, analytical, and therapeutic approaches to reveal a successful, multidisciplinary perspective to drug development
Includes detailed chapters on concepts, like protein dynamics, structure–based chemogenomics and polypharmacology, and fragment–based drug design
Illustrates advances in biomolecular targeting using case studies and emerging examples: epigenetic proteins, HCV inhibitors, HIV–1 inhibitors, ribosomes, and antibodies