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Therapeutic Antibody Engineering

  • ID: 3744454
  • Book
  • October 2017
  • Region: Global
  • 696 Pages
  • Elsevier Science and Technology
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The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering.

- Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships
- Integration of knowledge across all areas of antibody engineering, development, and marketing
- Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity
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Introduction to biologics and monoclonal antibodies
Value proposition for therapeutic monoclonal antibodies and Fc fusion proteins
Antibody structure-function relationships
Fundamental technologies for antibody engineering
Sources of antibody variable chains
Variable chain engineering
humanization and optimization approaches
Antibody interactions with the immune system
Monoclonal antibody targets and mechanisms of action
Therapeutic antibody classes
Antibody Fc engineering for optimal antibody performance
IgG glycans and glyco-engineering
Antibody fragments as therapeutics
Multiple antibody and multi-specificity approaches
FcFPs and similar constructs using Fc
Antibody-drug conjugates
Development issues: Antibody stability, developability, immunogenicity, and comparability
Interactions of human IgGs with non-human systems
Cell line development
Issues facing therapeutic monoclonal antibodies for the future.
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Strohl, William R
Dr William R. Strohl is Vice President of Biologics Research at Janssen R&D Biotechnology Center of Excellence, and was previously a leader in Merck's efforts to discover therapeutic monoclonal antibodies, as well as in-licensing of therapeutic targets and technologies associated with monoclonal antibodies. He has over 100 publications and several patents to his credit, and has edited two books.
Strohl, Lila M
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