The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer's Disease, Parkinson's, addiction, and cardiovascular dysregulation.
Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value.
- Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvement
- Presents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentally
- Provides expert commentary and a perspective on future trends at the end of each chapter
- Addresses translational advances and promising therapeutic options
- Includes references to key articles for additional detailed study
Part I. Introductory Chapters
Chapter 1. Anatomy of the Cerebral Cortex
Chapter 2. Cortical Plasticity in Response to Injury and Disease
Chapter 3. Imaging Approaches to Cerebral Cortex Pathology
Part II. The Cerebral Cortex in Neurodegenerative Disorders
Chapter 4. Alzheimer's Disease
Chapter 5. Vascular Dementia
Chapter 6. Frontotemporal Dementia
Chapter 7. Parkinson's Disease and the Cerebral Cortex
Chapter 8. Huntington Disease
Chapter 9. Cortical Manifestations in Amyotrophic Lateral Sclerosis
Chapter 10. Cortical Involvement in Multiple Sclerosis
Part III. The Cerebral Cortex in Neuropsychiatric Disorders
Chapter 11. Prefrontal Cortical Abnormalities in Cognitive Deficits of Schizophrenia
Chapter 12. Role of the Prefrontal Cortex in Addictive Disorders
Dr. David F. Cechetto is a Professor in the Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry at the University of Western Ontario. His research interests are in the role of inflammation in cerebral ischemia and vascular cognitive impairment and dementia. He has developed animal models for the investigation of the combined effects of Alzheimer's Disease and cerebral ischemia and other risk factors for vascular cognitive impairment such as diabetes, hypertension and atherosclerosis. He has also developed an agent with potential for the treatment of schizophrenia that targets a new unique class of receptors compared to current antipsychotic therapies. An additional area of research involves the examination of mental stress on cardiovascular reactivity (a risk factor for cardiovascular disease) and the regions of the human brain responsible for varying degrees of reactivity in individuals. He is principal investigator on numerous basic neuroscience studies with clinical implications. He has consulted for companies such as Upjohn, Servier (French), Uriach (Spanish), and Johnson & Johnson Pharmaceuticals.
Dr. Nina Weishaupt trained as a veterinarian before committing her career entirely to research in the neurological sciences. Her PhD thesis work in the field of spinal cord injury at the University of Alberta earned her a Dissertation Fellowship and resulted in a number of published articles. Nina has extensive experience with animal models of neurological conditions, and is currently developing a novel rat model for studying early events in the development of Alzheimer's Disease at the University of Western Ontario.