Next-Generation Sequencing (NGS) Process Report - Market Trends, Unmet Needs & Challenges, and Ecosystem Analysis

  • ID: 3771603
  • Report
  • Region: Global
  • 111 Pages
  • EnlightenBio
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Busy NGS Process Space with Commercial Leaders that Provide Sequencing Reagents, Instruments, and Analysis Solutions

FEATURED COMPANIES

  • Agilent Technologies
  • Bina Technologies (Roche)
  • CLC Bio (Qiagen)
  • DNAnexus
  • Genalice
  • Omicia
  • MORE
The NGS process space is extremely busy with many commercial players that provide sequencing reagents, instruments, and analysis solutions. An extensive analysis of this space highlights that as the sequencing technology has matured, the challenges have shifted toward data explosion and computing, data interpretation to gather and report actionable information, and information management.

This report is unique, in that it is not a predictive market research report, but rather builds on data gathered from the many end-user interviews and the data available in the scientific literature.

Our specific analysis identified the obvious top players which includes Illumina on the instruments side (and to some extent on the reagents side), Thermo Fisher Scientific, and Pacific Biosciences; Illumina also offers a data analysis and interpretation solution via BaseSpace. Agilent technologies, Qiagen, and Thermo Fisher Scientific are the main actors on the reagents side, while on the analysis side we observe several providers that are strong in different areas of data analysis and interpretation. DNAnexus and Seven Bridges Genomics have emerged as open and flexible platforms for data analysis, Bluebee, Genalice, and Edico Genome as alternatives enabling fast DNA processing. On the data interpretation side we have several noteworthy companies such as Congenica, Ingenuity (Qiagen), Omicia, Station X, or WuXi NextCODE offering elegant interpretation solutions. Alongside these established companies, we should not overlook the significant impact of open source tools that command a sizable share of the data analysis volume (~68% of all users still use in-house or open source tools for their analyses - some as standalone solutions and some in combination with commercially available offerings), such as the Broad Institute Scientific Community Software and Sanger Institute Tools and Software made available to the entire community.

Our data is substantiated with an analysis of the published NGS/sequencing literature, 28 interviews (19 end-users and nine industry representative interviews) highlighting product preferences for sample preparation and sample sequencing, customer/end-users unmet needs and challenges, and the brand perception users have for the different supplier companies and their products, plus an extensive comparative analysis of key players in the sequence data analysis and interpretation space. Furthermore, this report provides lists of top global organizations and researchers for the top sequencing applications (bioinformatics, RNA-seq, Sanger sequencing, exome, de novo assembly, variant calling, and ChIP-seq), as identified across the NGS/sequencing literature.

The approach taken to decipher the NGS process and its components, as summarized within this report, was rooted in the following questions: who are the key commercial companies in this process, who are the end-users and what are their unmet needs and challenges, and when researching the analysis and interpretation side of the equation, what challenges need the commercial life science product providers address, and who addresses them how?

This 111 page NGS Process Report consists of 23 Figures, 39 Tables, and 17 comprehensive company profiles (Agilent Technologies, Bina Technologies (Roche), Bluebee, CLC Bio (Qiagen), Congenica, DNAnexus, Edico Genome, Genalice, BaseSpace (Illumina), Ingenuity Systems (Qiagen), New England Biolabs, Omicia, Qiagen, Seven Bridges Genomics, Station X, Thermo Fisher Scientific, and WuXi NextCODE) which includes company metrics (funding, number of employees, etc.), product details, founder/executive and board information, additional notes, and the respective company vision.
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FEATURED COMPANIES

  • Agilent Technologies
  • Bina Technologies (Roche)
  • CLC Bio (Qiagen)
  • DNAnexus
  • Genalice
  • Omicia
  • MORE
Foreword
Learnings
Table of Figures
Table of Tables
The NGS Process
- The published NGS literature

1. The Lab Components Including Reagents & Sequencing Instruments
- Top life science product suppliers in the NGS literature
- Top products by reagents and sequencing instrument vendors
- Sequencing instruments in the literature
- Top 20 countries, institutions, and researchers across the NGS space

2. User type
- The non-computational researcher
- The computational researcher
- End-user sample and library preparation reagents and kits preferences
- End-user sequencing instrument preferences

3. The NGS Analysis and Interpretation Ecosystem
- NGS utilization and analysis challenges
- - Secondary analysis companies addressing NGS utilization and analysis challenges
- - Tertiary interpretation companies addressing NGS utilization and analysis challenges
- - End-user feedback on secondary analysis
- - End-user feedback on tertiary analysis
- Deep dive into secondary analysis and tertiary interpretational tool companies
- - Secondary analysis tool companies
- - - Data analysis speed, scalability, and flexibility
- - - Sequencing machine integration
- - Tertiary data interpretation tool companies
- - - Tertiary interpretation content
- - A comparative functionality assessment
- - - Infrastructure requirements
- - - Data security and compliance features
- - Partnerships
- - - Overview of partnerships in the analysis and interpretation space
- - Company momentum

4. Concluding notes
- Data explosion
- Training non-computational scientists
- Information management
- Knowledge extraction and actionable reporting
- End-to-end-solutions
- Reporting of clinical findings

5. Company/Product Profiles
- Agilent Technologies
- BaseSpace (Illumina)
- Bina Technologies
- Bluebee
- CLC Bio
- Congenica
- DNAnexus
- Edico Genome
- Genalice
- Ingenuity with IPA and IVA (Qiagen)
- New England Biolabs
- Omicia
- Qiagen
- Seven Bridges Genomics
- Station X
- Thermo Fisher Scientific
- Wuxi NextCODE Genomics

Appendix
- Companies in the data analysis and interpretation space
- Top countries, institutions, and researchers in the NGS literature

Abbreviations

About the publisher
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- Agilent Technologies
- BaseSpace (Illumina)
- Bina Technologies (Roche)
- Bluebee
- CLC Bio (Qiagen)
- Congenica
- DNAnexus
- Edico Genome
- Genalice
- Ingenuity Systems (Qiagen)
- New England Biolabs
- Omicia
- Qiagen
- Seven Bridges Genomics
- Station X
- Thermo Fisher Scientific
- WuXi NextCODE
Note: Product cover images may vary from those shown
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