Hemoglobinopathy is a collective term used for the blood disorder that primarily affects the red blood cells (RBCs). The abnormal production or structural change in the hemoglobin molecule causes hemoglobinopathies. Majorly, hemoglobinopathies are divided into two groups, namely abnormal structural hemoglobin variant and thalassemia. The abnormal structural hemoglobin variants are caused by mutations in the hemoglobin gene structure and thalassemia is occurred by abnormal or underproduction of hemoglobin molecules. Many hemoglobinopathies currently have some approved drugs in the market and some drugs are in development stages.
The increasing prevalence of sickle cell disease (SCD) and thalassemia is expected to drive the market growth. The key driver for the growth of the global hemoglobinopathies market is increasing prevalence of hemoglobinopathies in under-developed and developing countries. In addition, the lack of awareness and low diagnosis rate are some major factors increasing the prevalence of the hemoglobinopathies. Moreover, the lack of treatment alternatives, unavailability of treatments and low diagnosis rate are the factors restraining the growth of the global hemoglobinopathies market during the forecast period. The hemoglobinopathies market is projected to grow with the arrival of treatments for beta thalassemia and sickle cell diseases. Treatments based on transfer of genetically corrected stem cells, in which the lentiviral vectors transfer beta globin chain, and the transcription is regulated by the beta globin locus. For instance, there are various factors limiting growth of the market, such as insufficient stem-cell quantity and quality, gene expression complexity, and high cost of the treatment.
The hemoglobinopathies market is segmented on the basis of disease type, type of therapy, distribution channel, and region. By disease type, the market is segmented into thalassemia, sickle cell disease, and others. The other segment is further classified into hemoglobin (Hb) variants, beta thalassemia, alpha thalassemia, and porphyria. On the basis of type of therapy, the market is segmented into monoclonal antibody medication, angiotensin-converting enzyme (ACE) inhibitors, stem cell transplantation, hydroxyurea, and others. The other segment is further classified into gene therapy, iron chelation therapy, blood transfusion, and bone marrow transplant. By distribution channel, the market is segmented into hospital pharmacy, online providers, and drug stores and retail pharmacy.
Region-wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA. Major key players that operate in the global hemoglobinopathies market are Abbott Laboratories, Alnylam Pharmaceuticals, Biogen Idec, Bluebird, Inc, Bristol Myers Squibb Company, Canthera Discovery Ltd., Danaher, Emmacus Life Science Inc, F. Hoffman-La Roche Ag, Gamida Cell Ltd, Global blood therapeutics, Merck & Co., Novartis AG, Pfizer, Inc, Prolong Pharmaceuticals, LLC, Sangamo Therapeutics, and Sanofi.
The increasing prevalence of sickle cell disease (SCD) and thalassemia is expected to drive the market growth. The key driver for the growth of the global hemoglobinopathies market is increasing prevalence of hemoglobinopathies in under-developed and developing countries. In addition, the lack of awareness and low diagnosis rate are some major factors increasing the prevalence of the hemoglobinopathies. Moreover, the lack of treatment alternatives, unavailability of treatments and low diagnosis rate are the factors restraining the growth of the global hemoglobinopathies market during the forecast period. The hemoglobinopathies market is projected to grow with the arrival of treatments for beta thalassemia and sickle cell diseases. Treatments based on transfer of genetically corrected stem cells, in which the lentiviral vectors transfer beta globin chain, and the transcription is regulated by the beta globin locus. For instance, there are various factors limiting growth of the market, such as insufficient stem-cell quantity and quality, gene expression complexity, and high cost of the treatment.
The hemoglobinopathies market is segmented on the basis of disease type, type of therapy, distribution channel, and region. By disease type, the market is segmented into thalassemia, sickle cell disease, and others. The other segment is further classified into hemoglobin (Hb) variants, beta thalassemia, alpha thalassemia, and porphyria. On the basis of type of therapy, the market is segmented into monoclonal antibody medication, angiotensin-converting enzyme (ACE) inhibitors, stem cell transplantation, hydroxyurea, and others. The other segment is further classified into gene therapy, iron chelation therapy, blood transfusion, and bone marrow transplant. By distribution channel, the market is segmented into hospital pharmacy, online providers, and drug stores and retail pharmacy.
Region-wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA. Major key players that operate in the global hemoglobinopathies market are Abbott Laboratories, Alnylam Pharmaceuticals, Biogen Idec, Bluebird, Inc, Bristol Myers Squibb Company, Canthera Discovery Ltd., Danaher, Emmacus Life Science Inc, F. Hoffman-La Roche Ag, Gamida Cell Ltd, Global blood therapeutics, Merck & Co., Novartis AG, Pfizer, Inc, Prolong Pharmaceuticals, LLC, Sangamo Therapeutics, and Sanofi.
KEY BENEFITS FOR STAKEHOLDERS
- This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the hemoglobinopathies market analysis from 2021 to 2031 to identify the prevailing hemoglobinopathies market opportunities.
- The market research is offered along with information related to key drivers, restraints, and opportunities.
- Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
- In-depth analysis of the hemoglobinopathies market segmentation assists to determine the prevailing market opportunities.
- Major countries in each region are mapped according to their revenue contribution to the global market.
- Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
- The report includes the analysis of the regional as well as global hemoglobinopathies market trends, key players, market segments, application areas, and market growth strategies.
Key Market Segments
By Type
- Thalassemia
- Sickle Cell Disease
- Others
By Therapy
- Monoclonal Antibody Medication
- ACE inhibitors
- Hydroxyurea
- Others
By Distribution Channel
- Hospital Pharmacy
- Online Providers
- Drug Stores and Retail Pharmacy
By Region
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- France
- UK
- Italy
- Spain
- Rest of Europe
- Asia-Pacific
- Japan
- China
- Australia
- India
- South Korea
- Rest of Asia-Pacific
- LAMEA
- Brazil
- Saudi Arabia
- South Africa
- Rest of LAMEA
Key Market Players
- Abbott Laboratories
- Alnylam Pharmaceuticals, Inc.
- Biogen idc
- Bluebird, Inc.
- Bristol Myers Squibb
- Danaher Corporation
- Emmaus Life Sciences, Inc.
- Global Blood Therapeutics, Inc.
- Merck & Co. Inc.
- Novartis AG
- Pfizer
- Prolong Pharmaceuticals
- Sangamo Therapeutics, Inc.
- Sanofi
- Cancer Therapeutics CRC Pty Ltd
- Gamida-Cell Ltd.
Table of Contents
CHAPTER 1: INTRODUCTION
CHAPTER 2: EXECUTIVE SUMMARY
CHAPTER 3: MARKET OVERVIEW
CHAPTER 4: HEMOGLOBINOPATHIES MARKET, BY TYPE
CHAPTER 5: HEMOGLOBINOPATHIES MARKET, BY THERAPY
CHAPTER 6: HEMOGLOBINOPATHIES MARKET, BY DISTRIBUTION CHANNEL
CHAPTER 7: HEMOGLOBINOPATHIES MARKET, BY REGION
CHAPTER 8: COMPANY LANDSCAPE
CHAPTER 9: COMPANY PROFILES
List of Tables
List of Figures
Executive Summary
According to the report, titled, “Hemoglobinopathies Market," the hemoglobinopathies market was valued at $4.2 billion in 2021, and is estimated to reach $7 billion by 2031, growing at a CAGR of 5.2% from 2022 to 2031.Hemoglobinopathies is a group of inherited blood disorders caused by change in the hemoglobin molecule due to mutation of the gene. This primarily affects the red blood cells (RBCs), in which hemoglobin molecule is present to carry the oxygen. In most of the cases, hemoglobinopathies are inherited from parents to offspring. The diagnosis methods for the disease detections are total blood count, hematological tests, and DNA mutation analysis. The global hemoglobinopathies market share is expected to expand as more research and development (R&D) activities are conducted in an effort to create an effective treatment. During the forecast period, the hemoglobinopathies market growth is expected to boost by expanding government programs and investments for the development of innovative medications and spread of more consciousness about hemoglobinopathies. The market is expected to accelerate due to rise in prevalence of hemoglobinopathies in the developing and low-cost countries. The introduction of the new iron-chelation therapy for thalassemia will also help in market expansion. The increasing prevalence of sickle cell disease (SCD) and thalassemia is expected to drive the market growth. The key driver for the growth of the global hemoglobinopathies industry is increasing prevalence of hemoglobinopathies in under-developed and developing countries. In addition, the lack of awareness and low diagnosis rate are some major factors increasing the prevalence of the hemoglobinopathies. Moreover, the lack of treatment alternatives, unavailability of treatments and low diagnosis rate are the factors restraining the growth of the global hemoglobinopathies market during the forecast period.
Furthermore, the hemoglobinopathies market is expected to increase rapidly due to the various new therapies are in the approval and development stages. The hemoglobinopathies market size is also advancing due to the expansion of the pharmaceutical and healthcare industries and DNA therapies. On the other hand, lack of effective treatments, unavailability of stem-cells, and their high cost are anticipated to restrain the expansion of the global hemoglobinopathies market trends. The need for hemoglobinopathies significantly decreased after the COVID-19 pandemic. The focus of medical professionals, governments and the general public has moved to containing the virus's spread as a result of the fatal virus's quick expansion. It consequently decreased the need for hemoglobinopathies therapy. People visited clinics and hospitals only if they had an emergency. As a result, the COVID-19 pandemic caused severe disruptions in the market for diagnosis and treatment of the hemoglobinopathies.
Coronavirus severe acute respiration syndrome (SARS-CoV-2) is an infectious disease caused by the novel coronavirus (COVID-19), which originated in the Wuhan district in China in the late 2019, and since has spread to 212 countries. The virus was initially referred to as “novel coronavirus 2019” (2019-nCoV) by the WHO, However, on February 11, 2020, it was given the official name of SARS-CoV-2 by the International Committee on Taxonomy of Viruses. WHO declared COVID-19 as pandemic on March 11, 2020, and by September 1, 2020, over 28.1 million people have been infected globally with over 909,000 deaths. COVID-19 symptoms include fever, cough, and shortness of breath.
Nearly all industries have been impacted by the global public health COVID-19 pandemic. As coronavirus crises sweep the globe and force healthcare organizations to devote the majority of their funds to fight COVID-19, the outbreak of COVID-19 has resulted in a significant decline in demand for the hemoglobinopathies market across several sectors, particularly the health and pharmaceutical sectors. The main cause of the interruptions experienced by patients getting treatment for hemoglobinopathies in hospitals was the risk of infection. The treatments for thalassemia and sickle cell disease requires hospitalization for blood transfusion and bone marrow transplantation, hence the market growth declined in this period. As a result, the COVID-19 outbreak is expected to slow down the global market growth for treatments of hemoglobinopathies, which will have a negative effect on the market's value in 2022 and beyond.
By disease type, the thalassemia segment dominated the market in 2021 and is expected to remain dominant during the forecast period. The factors responsible for the segment growth are increase in thalassemia prevalence and increase in approval of the novel treatments for thalassemia, such as Committee for Medicinal Products for Human Use approved Luspatercept in 2020 for beta thalassemia. Furthermore, increased demand for gene therapy and stem cell therapy supported the segment growth during the forecast period.
Depending on type of therapy, the monoclonal antibody medication segment dominated the market in 2021 and is expected to remain dominant during the forecast period. The use of antibody medication has increased over past years as new drugs have been approved, including Oxbryta (voxelotor), approved by the U.S FDA to treat sickle cell disease. Furthermore, the strong emerging pipeline of novel medication is expected to drive the segment growth.
On the basis of distribution channel, the drug stores and retail pharmacy segment dominated the market in 2021 and is expected to remain dominant during the forecast period. The market growth of this segment is driven by increase in prescription drug. Also, during COVID-19 pandemic people preferred drug stores and retail pharmacy ultimately led to increased segmental growth. Region-wise, North America has the highest market share.
Major key players that operate in the global hemoglobinopathies market are Abbott Laboratories, Alnylam Pharmaceuticals, Biogen Idec, Bluebird, Inc, Bristol Myers Squibb Company, Canthera Discovery Ltd., Danaher, Emmacus Life Science Inc, F. Hoffman-La Roche Ag, Gamida Cell Ltd, Global blood therapeutics, Merck & Co., Novartis AG, Pfizer, Inc, Prolong Pharmaceuticals, LLC, Sangamo Therapeutics, and Sanofi.
Key Findings of the Study
- · By disease type, thalassemia dominated the market in 2021 and is expected to remain dominant during the forecast period.
· By distribution channel, the drug stores and retail pharmacy held the largest market share in 2021.
Region-wise, North America dominated the market in 2021 and is expected to grow at a CAGR of 5.4%.
Companies Mentioned
- Abbott Laboratories
- Alnylam Pharmaceuticals, Inc.
- Biogen Idc
- Bluebird, Inc.
- Bristol Myers Squibb
- Danaher Corporation
- Emmaus Life Sciences, Inc.
- Global Blood Therapeutics, Inc.
- Merck & Co. Inc.
- Novartis AG
- Pfizer
- Prolong Pharmaceuticals
- Sangamo Therapeutics, Inc.
- Sanofi
- Cancer Therapeutics Crc Pty Ltd
- Gamida-Cell Ltd.
Methodology
The analyst offers exhaustive research and analysis based on a wide variety of factual inputs, which largely include interviews with industry participants, reliable statistics, and regional intelligence. The in-house industry experts play an instrumental role in designing analytic tools and models, tailored to the requirements of a particular industry segment. The primary research efforts include reaching out participants through mail, tele-conversations, referrals, professional networks, and face-to-face interactions.
They are also in professional corporate relations with various companies that allow them greater flexibility for reaching out to industry participants and commentators for interviews and discussions.
They also refer to a broad array of industry sources for their secondary research, which typically include; however, not limited to:
- Company SEC filings, annual reports, company websites, broker & financial reports, and investor presentations for competitive scenario and shape of the industry
- Scientific and technical writings for product information and related preemptions
- Regional government and statistical databases for macro analysis
- Authentic news articles and other related releases for market evaluation
- Internal and external proprietary databases, key market indicators, and relevant press releases for market estimates and forecast
Furthermore, the accuracy of the data will be analyzed and validated by conducting additional primaries with various industry experts and KOLs. They also provide robust post-sales support to clients.
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