World Biomaterials (Bio Implants) Market - Opportunities and Forecasts, 2014 - 2022

  • ID: 3773327
  • Report
  • Region: Global
  • 155 pages
  • Allied Analytics LLP
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Biomaterials are materials of either synthetic or natural origin that are used for interaction with biological systems for medical purposes such as treating or repairing damage tissues. They are used in joint replacements, plastic surgeries, drug delivery devices, skin repair, heart valves, and in other medical implants. The recent success in the usage of biomaterials was witnessed in the fields of cardiovascular medicine, immunology, orthopedics, dental medicine, infection, and ophthalmology, which has opened new avenues for biomaterials technology. Biomaterial is a groundbreaking technological innovation of medical technology that can enhance the functionalities of damaged tissues or organs.

The world biomaterials market is estimated to garner revenues worth $139,736 million by 2022, and projected to grow at a CAGR of 11.8% from 2016 to 2022. This is attributed to increase in geriatric population, rise in prevalence rates of cardiovascular & orthopedic disorders, advancement in medical technology, and increase in awareness regarding implantable devices. The other driving factors of the market are heavy fundings by government to increase R&D activities in the field of biomaterials and increasing awareness about the advantages of biomaterials products. However, high cost of biomaterial implants and compatibility issues are expected to hamper the market growth. Introduction of new technologies, namely, decellularized dermal matrixes for grafting and hydrogen scaffolding, presenting new products in field of plastic surgery, wound healing, and neurology offers lucrative opportunities to market players.

The report segments the world biomaterials market based on type, application, and geography. By type, the market is segmented into metallic, polymeric, ceramic, and natural. Metallic biomaterials are segmented into stainless steel, titanium & titanium alloys, cobalt-chrome alloys, gold, and silver. Polymeric biomaterials are divided into polymethyl methacrylate (PMMA), polyethylene, polyester, polyvinylchloride, silicone rubber, nylon, and polyetheretherketone. Ceramic biomaterials are segmented into calcium phosphate, zirconia, aluminum oxide, calcium sulfate, carbon, and glass. Natural biomaterials comprise hyaluronic acid, collagen & gelatin, fibrin, cellulose, chitin, alginates, and silk. Based on application, the market is classified into cardiovascular, dental, orthopedic, wound healing, plastic, surgery, ophthalmology, tissue engineering, neurological disorders, and drug delivery systems. The market has been analyzed based on four geographical regions, namely North America, Europe, Asia-Pacific, and LAMEA.

Introduction of novel biomaterials, such as inorganic nanomaterials for detecting enzyme activity is a recent trend of the industry. In July 2016, Cartiva, Inc. received premarket approval for Cartiva Synthetic Cartilage Implant (SCI) that is used for the treatment of osteoarthritis at the base of the great toe, where SCI is a synthetic cartilage joint formed by an organic polymer-based biomaterial. Furthermore, in December 2014, Karmed Saglik Group received first European approval for implant made using PEEK-OPTIMA™ HA enhanced polymer by Invibio Biomaterial Solutions. These implants are used for the treatment of degenerative spinal conditions. Acquisitions and partnerships are the key strategies adopted by market players in the biomaterial industry.

The key market players profiled in the report include:

Royal DSM
Wright Medical Technology, Inc.
Corbion N.V.
Zimmer Biomet Holdings, Inc.
Bayer AG
Carpenter Technology Corporation
Covalon Technologies Ltd.
Evonik Industries AG
BASF SE
Invibio Ltd.
Collagen

Key benefits

This report provides an extensive analysis of the current and emerging market trends and dynamics of the world biomaterials market.
In-depth analysis of the market is based on market estimations of key market segments for the period of 2014-2022.
This report analyzes the competitive landscape and value chain of the market to understand the competitive environment across geographies.
Region-wise and country-wise analysis of the world biomaterials market is provided in the report.
Comprehensive analyses of all regions are provided to determine the prevailing opportunities across various geographies.
Comprehensive analysis of the current research and developments in the world artificial biomaterials market along with key market dynamic factors have been provided in the report to understand the market scenario.

Key market segments

The world biomaterials market is segmented as follows:

By Type

Metallic
Stainless Steel
Titanium & Titanium Alloys
Cobalt-Chrome Alloys
Gold
Silver
Polymeric
Polymethylmethacrylate (PMMA)
Polyethylene
Polyester
Polyvinylchloride
Silicone Rubber
Nylon
Polyetheretherketone
Ceramic
Calcium Phosphate
Zirconia
Aluminum Oxide
Calcium Sulfate
Carbon
Glass
Natural
Hyaluronic Acid
Collagen & Gelatin
Fibrin
Cellulose
Chitin
Alginates
Silk

By Application

Cardiovascular
Dental
Orthopedic
Wound Healing
Plastic Surgery
Ophthalmology
Tissue Engineering
Neurological Disorders
Drug-Delivery Systems

By Geography

North America
U.S.
Canada
Mexico
Europe
Germany
France
United Kingdom
Others
Asia-Pacific
Japan
China
India
Others
Latin America, Middle East, and Africa (LAMEA)
Brazil
Turkey
Saudi Arabia
Republic of South Africa
Others
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CHAPTER 1 INTRODUCTION
1.1 Report description
1.2 Key benefits
1.3 Key market segments
1.4 Research methodology
1.4.1 Secondary research
1.4.2 Primary research
1.4.3 Analyst tools and models

CHAPTER 2 EXECUTIVE SUMMARY
2.1 CXO Perspective

CHAPTER 3 MARKET OVERVIEW
3.1 Market definition and scope
3.2 Key findings
3.2.1 Top investment pockets
3.2.2 Top winning strategies
3.3 Porters five forces analysis
3.3.1 Bargaining power of suppliers
3.3.2 Bargaining power of buyers
3.3.3 Threat of new entrants
3.3.4 Threat of substitutes
3.3.5 Competitive rivalry
3.4 Market dynamics
3.4.1 Drivers
3.4.1.1 Rise in geriatric population
3.4.1.2 Rise in prevalence of cardiovascular and orthopedic disorders
3.4.1.3 Rising demand for implantable devices
3.4.1.4 Advancements in medical technology
3.4.1.5 Advantages of biomaterials products
3.4.1.6 Heavy funding by government agencies
3.4.2 Restraints
3.4.2.1 High cost of biomaterial production
3.4.2.2 Compatibility issues
3.4.2.3 Difficulty in wearing the products
3.4.3 Opportunities
3.4.3.1 Introduction of decellularized dermal matrixes for grafting and hydrogel scaffolding
3.4.3.2 Introduction of new products in plastic surgery, wound healing, and neurology sector

CHAPTER 4 WORLD BIOMATERIALS MARKET, BY TYPE, 2014-2022
4.1 Overview
4.1.1 Market size and forecast
4.2 Metallic
4.2.1 Key market trends
4.2.2 Key growth factors and opportunities
4.2.3 Market size and forecast
4.2.4 Stainless steel
4.2.6 Titanium & titanium alloys
4.2.8 Cobalt-chrome alloys
4.2.10 Gold
4.2.12 Silver
4.3 Polymeric
4.3.1 Key market trends
4.3.2 Key growth factors and opportunities
4.3.3 Market size and forecast
4.3.4 Polymethylmethacrylate (PMMA)
4.3.6 Polyethylene
4.3.8 Polyester
4.3.10 Polyvinylchloride
4.3.12 Silicone rubber
4.3.14 Nylon
4.3.16 Polyetheretherketone
4.4 Ceramic
4.4.1 Key market trends
4.4.2 Key growth factors and opportunities
4.4.3 Market size and forecast
4.4.4 Calcium phosphate
4.4.5 Calcium phosphate market size & forecast
4.4.6 Zirconia
4.4.8 Aluminum oxide
4.4.10 Calcium sulfate
4.4.12 Carbon
4.4.14 Glass
4.5 Natural
4.5.1 Key market trends
4.5.2 Key growth factors and opportunities
4.5.1 Market size and forecast
4.5.2 Hyaluronic acid
4.5.4 Collagen & gelatin
4.5.6 Fibrin
4.5.8 Cellulose
4.5.10 Chitin
4.5.12 Alginates
4.5.14 Silk

CHAPTER 5 WORLD BIOMATERIALS MARKET, BY APPLICATION, 2014-2022
5.1 Overview
5.1.1 Market size and forecast
5.2 Cardiovascular
5.2.1 Market size and forecast
5.3 Dental
5.3.1 Market size and forecast
5.4 Orthopedic
5.4.1 Market size and forecast
5.5 Wound healing
5.5.1 Market size and forecast
5.6 Plastic surgery
5.6.1 Market size and forecast
5.7 Ophthalmology
5.7.1 Market size and forecast
5.8 Tissue engineering
5.8.1 Market size and forecast
5.9 Neurological disorders
5.9.1 Market size and forecast
5.10 Drug delivery systems
5.10.1 Market size and forecast

CHAPTER 6 WORLD BIOMATERIALS MARKET, BY GEOGRAPHY, 2014-2022
6.1 Overview
6.1.1 Market size and forecast
6.1 North America
6.1.1 Key market trends
6.1.2 Key growth factors and opportunities
6.1.3 Market size and forecast
6.1.4 U.S. market size and forecast
6.1.5 Canada market size and forecast
6.1.6 Mexico market size and forecast
6.2 Europe
6.2.1 Key market trends
6.2.2 Key growth factors and opportunities
6.2.3 Market size and forecast
6.2.4 Germany market size and forecast
6.2.5 France market size and forecast
6.2.6 U.K. market size and forecast
6.2.7 Italy market size and forecast
6.2.8 Spain market size and forecast
6.2.9 Russia market size and forecast
6.2.10 Others market size and forecast
6.3 Asia-Pacific
6.3.1 Key market trends
6.3.2 Key growth factors and opportunities
6.3.3 Market size and forecast
6.3.4 Japan market size and forecast
6.3.5 China market size and forecast
6.3.6 Australia market size and forecast
6.3.7 India market size and forecast
6.3.8 South Korea market size and forecast
6.3.9 Taiwan market size and forecast
6.3.10 Others market size and forecast
6.4 LAMEA
6.4.1 Key market trends
6.4.2 Key growth factors and opportunities
6.4.3 Market size and forecast
6.4.4 Brazil market size and forecast
6.4.5 Turkey market size and forecast
6.4.6 Venezuela market size and forecast
6.4.7 Saudi Arabia market size and forecast
6.4.8 Republic of South Africa market size and forecast
6.4.9 Others market size and forecast

CHAPTER 7 COMPANY PROFILES
7.1 Royal DSM
7.1.1 Company overview
7.1.2 Operating business segments
7.1.3 Business performance
7.1.4 Key strategic moves & developments
7.2 Wright Medical Group N.V.
7.2.1 Company overview
7.2.2 Operating business segments
7.2.3 Business performance
7.2.4 Key strategic moves & developments
7.3 Corbion N.V.
7.3.1 Company overview
7.3.2 Operating business segments
7.3.3 Business performance
7.3.4 Key strategic moves & developments
7.4 Zimmer Biomet Holdings, Inc.
7.4.1 Company overview
7.4.2 Operating business segments
7.4.3 Business performance
7.4.4 Key strategic moves & developments
7.5 Bayer AG
7.5.1 Company overview
7.5.2 Operating business segments
7.5.3 Business performance
7.6 Carpenter Technology Corporation
7.6.1 Company overview
7.6.2 Operating business segments
7.6.3 Business performance
7.7 Covalon Technologies Ltd.
7.7.1 Company overview
7.7.2 Operating business segments
7.7.3 Business performance
7.8 Evonik Industries AG
7.8.1 Company overview
7.8.2 Operating business segments
7.8.3 Business performance
7.8.4 Key strategic moves & developments
7.9 BASF SE
7.9.1 Company overview
7.9.2 Operating business segments
7.9.3 Business performance
7.10 Victrex plc.
7.10.1 Company overview
7.10.2 Operating business segments
7.10.3 Business performance
7.10.4 Key strategic moves & developments
7.11 Collagen Matrix, Inc.
7.11.1 Company overview
7.11.2 Operating business segments
Table 1 World Biomaterials Market, By Type, 2014-2022 ($Million)
Table 2 World Metallic Biomaterials Market, By Type, 2014-2022 ($Million)
Table 3 World Polymeric Biomaterials Market, By Type, 2014-2022 ($Million)
Table 4 World Ceramics Biomaterials Market, By Type, 2014-2022 ($Million)
Table 5 World Natural Biomaterials Market, By Type, 2014-2022 ($Million)
Table 6 World Biomaterials Market, By Application, 2014-2022 ($Million)
Table 7 World Cardiovascular Biomaterials Market, By Region, 2014-2022 ($Million)
Table 8 World Dental Biomaterials Market, By Region, 2014-2022 ($Million)
Table 9 World Orthopedic Biomaterials Market, By Region, 2014-2022 ($Million)
Table 10 World Wound Healing Biomaterials Market, By Region, 2014-2022 ($Million)
Table 11 World Plastic Surgery Biomaterials Market, By Region, 2014-2022 ($Million)
Table 12 World Ophthalmology Biomaterials Market, By Region, 2014-2022 ($Million)
Table 13 World Tissue Engineering Biomaterials Market, By Region, 2014-2022 ($Million)
Table 14 World Neurological Disorders Biomaterials Market, By Region, 2014-2022 ($Million)
Table 15 World Drug Delivery Systems Biomaterials Market, By Region, 2014-2022 ($Million)
Table 16 World Biomaterials Market, By Region, 2014-2022 ($Million)
Table 17 North America Biomaterials Market, By Country, 2014-2022 ($Million)
Table 18 North America Biomaterials Market, By Type, 2014-2022 ($Million)
Table 19 North America Biomaterials Market, By Application, 2014-2022 ($Million)
Table 20 Europe Biomaterials Market, By Country, 2014-2022 ($Million)
Table 21 Europe Biomaterials Market, By Type, 2014-2022 ($Million)
Table 22 Europe Biomaterials Market, By Application, 2014-2022 ($Million)
Table 23 Asia-Pacific Biomaterials Market, By Country, 2014-2022 ($Million)
Table 24 Asia-Pacific Biomaterials Market, By Type, 2014-2022 ($Million)
Table 25 Asia-Pacific Biomaterials Market, By Application, 2014-2022 ($Million)
Table 26 Lamea Biomaterials Market, By Country, 2014-2022 ($Million)
Table 27 Lamea Biomaterials Market, By Type, 2014-2022 ($Million)
Table 28 Lamea Biomaterials Market, By Application, 2014-2022 ($Million)
Table 29 Royal Dsm - Company Snapshot
Table 30 Royal Dsm - Segment Information
Table 31 Wright Medical - Company Snapshot
Table 32 Wright Medical - Operating Segments
Table 33 Corbion N.V. - Company Snapshot
Table 34 Corbion N.V. - Business Segment
Table 35 Zimmer Biomet - Company Snapshot
Table 36 Zimmer Biomet - Operating Segments
Table 37 Bayer - Company Snapshot
Table 38 Bayer - Operating Segments
Table 39 Carpenter - Company Snapshot
Table 40 Carpenter - Operating Segments
Table 41 Covalon - Company Snapshot
Table 42 Covalon - Business Segments
Table 43 Evonik - Company Snapshot
Table 44 Evonik - Business Segment
Table 45 Basf Se - Company Snapshot
Table 46 Basf Se - Operating Segments
Table 47 Victrex - Company Snapshot
Table 48 Victrex - Operating Segments
Table 49 Collagen Matrix - Company Snapshot
Table 50 Collagen Matrix - Operating Segments
Fig. 1 Top Investment Pockets In World Biomaterials Market
Fig. 2 Top Winning Strategies: Percentage Distribution (2014-2016)
Fig. 3 Top Winning Strategies
Fig. 4 Porters Five Forces Analysis
Fig. 5 Top Impacting Factors
Fig. 6 Stainless Steel Biomaterials Market, 2014-2022 ($Million)
Fig. 7 Titanium & Titanium Alloys Biomaterials Market, 2014-2022 ($Million)
Fig. 8 Cobalt-Chrome Alloys Biomaterials Market, 2014-2022 ($Million)
Fig. 9 Gold Biomaterials Market, 2014-2022 ($Million)
Fig. 10 Silver Biomaterials Market, 2014-2022 ($Million)
Fig. 11 Polymethylmethacrylate Biomaterials Market, 2014-2022 ($Million)
Fig. 12 Polyethylene Biomaterials Market, 2014-2022 ($Million)
Fig. 13 Polyester Biomaterials Market, 2014-2022 ($Million)
Fig. 14 Polyvinylchloride Biomaterials Market, 2014-2022 ($Million)
Fig. 15 Silicone Rubber Biomaterials Market, 2014-2022 ($Million)
Fig. 16 Nylon Biomaterials Market, 2014-2022 ($Million)
Fig. 17 Polyetheretherketone Biomaterials Market, 2014-2022 ($Million)
Fig. 18 Calcium Phosphate Biomaterials Market, 2014-2022 ($Million)
Fig. 19 Zirconia Biomaterials Market, 2014-2022 ($Million)
Fig. 20 Aluminum Oxide Biomaterials Market, 2014-2022 ($Million)
Fig. 21 Calcium Sulfate Biomaterials Market, 2014-2022 ($Million)
Fig. 22 Carbon Biomaterials Market, 2014-2022 ($Million)
Fig. 23 Glass Biomaterials Market, 2014-2022 ($Million)
Fig. 24 Hyaluronic Acid Biomaterials Market, 2014-2022 ($Million)
Fig. 25 Collagen & Gelatin Biomaterials Market, 2014-2022 ($Million)
Fig. 26 Fibrin Biomaterials Market, 2014-2022 ($Million)
Fig. 27 Cellulose Biomaterials Market, 2014-2022 ($Million)
Fig. 28 Chitin Biomaterials Market, 2014-2022 ($Million)
Fig. 29 Alginates Biomaterials Market, 2014-2022 ($Million)
Fig. 30 Silk Biomaterials Market, 2014-2022 ($Million)
Fig. 31 U.S. Biomaterials Market, 2014-2022 ($Million)
Fig. 32 Canada Biomaterials Market, 2014-2022 ($Million)
Fig. 33 Mexcio Biomaterials Market, 2014-2022 ($Million)
Fig. 34 Germany Biomaterials Market, 2014-2022 ($Million)
Fig. 35 France Biomaterials Market, 2014-2022 ($Million)
Fig. 36 U.K. Biomaterials Market, 2014-2022 ($Million)
Fig. 37 Italy Biomaterials Market, 2014-2022 ($Million)
Fig. 38 Spain Biomaterials Market, 2014-2022 ($Million)
Fig. 39 Russia Biomaterials Market, 2014-2022 ($Million)
Fig. 40 Others Biomaterials Market, 2014-2022 ($Million)
Fig. 41 Japan Biomaterials Market, 2014-2022 ($Million)
Fig. 42 China Biomaterials Market, 2014-2022 ($Million)
Fig. 43 Australia Biomaterials Market, 2014-2022 ($Million)
Fig. 44 India Biomaterials Market, 2014-2022 ($Million)
Fig. 45 South Korea Biomaterials Market, 2014-2022 ($Million)
Fig. 46 Taiwan Biomaterials Market, 2014-2022 ($Million)
Fig. 47 Others Biomaterials Market, 2014-2022 ($Million)
Fig. 48 Brazil Biomaterials Market, 2014-2022 ($Million)
Fig. 49 Turkey Biomaterials Market, 2014-2022 ($Million)
Fig. 50 Venezuela Biomaterials Market, 2014-2022 ($Million)
Fig. 51 Saudi Arabia Biomaterials Market, 2014-2022 ($Million)
Fig. 52 Republic Of South Africa Biomaterials Market, 2014-2022 ($Million)
Fig. 53 Others Biomaterials Market, 2014-2022 ($Million)
Fig. 54 Royal Dsm: Revenue By Year ($Million)
Fig. 55 Royal Dsm: Revenue By Segment, 2015 (%)
Fig. 56 Royal Dsm: Revenue By Geography, 2015 (%)
Fig. 57 Wright Medical: Revenue By Year ($Million)
Fig. 58 Wright Medical: Revenue By Segment, 2015 (%)
Fig. 59 Wright Medical: Revenue By Geography, 2015 (%)
Fig. 60 Corbion N.V.: Revenue By Year ($Million)
Fig. 61 Corbion N.V.: Revenue By Segment, 2015 (%)
Fig. 62 Corbion N.V.: Revenue By Geography, 2015 (%)
Fig. 63 Zimmer Biomet: Revenue By Year ($Million)
Fig. 64 Zimmer Biomet: Revenue By Segment, 2015 (%)
Fig. 65 Zimmer Biomet: Revenue By Geography, 2015 (%)
Fig. 66 Bayer: Revenue By Year ($Million)
Fig. 67 Bayer: Revenue By Segment, 2015 (%)
Fig. 68 Bayer: Revenue By Geography, 2015 (%)
Fig. 69 Carpenter: Reveneu By Year ($Million)
Fig. 70 Carpenter: Revenue By Segment, 2015 (%)
Fig. 71 Carpenter: Revenue By Market, 2015 (%)
Fig. 72 Carpenter: Revenue By Geography, 2015 (%)
Fig. 73 Covalon: Revenue By Year ($Million)
Fig. 74 Evonik: Revenue By Year ($Million)
Fig. 75 Evonik: Revenue By Segment, 2015 (%)
Fig. 76 Evonik: Revenue By Geography, 2015 (%)
Fig. 77 Basf Se: Revenue By Year ($Million)
Fig. 78 Basf Se: Revenue By Segment, 2015 (%)
Fig. 79 Basf Se: Revenue By Geography, 2015 (%)
Fig. 80 Victrex: Revenue By Year ($Million)
Fig. 81 Victrex: Revenue By Segment, 2015 (%)
Fig. 82 Victrex: Revenue By Geography, 2015 (%)
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Global biomaterials market is expected to reach $139 billion by 2022, from $62 billion in 2015, growing at a CAGR of 11.8% from 2016 to 2022, according to Allied Market Research. Metallic biomaterials segment is expected to contribute significantly to the global market revenue until 2022. North America held the leading position in the global market in 2015, and is expected to maintain its lead throughout the study period.

Metallic biomaterials segment contributed the highest revenue share to the global market, owing to highly used in orthopedic treatments for bone support and replacement, due to their strength and resistance to fatigue degradation. Polymeric biomaterials segment is projected to grow at a CAGR of 13.0% from 2016 to 2022, due to increasing demand for biodegradable products, and their use in various applications due their unique features such as flexibility, lightweight, remarkable biocompatibility, and physical & mechanical properties.

Orthopedic disorder was the leading application segment in the market, followed by cardiovascular disorders and drug-delivery systems segments, cumulatively contributing about three-fourths shares of the global market. This was attributed to the high incidence of conditions characterized by degenerative symptoms and notable relief offered by the use of biomaterial-based products. Neurological disorder is an another key application area of the biomaterials market, and is expected to offer lucrative investment opportunities to market players in the near future. However, tissue engineering is projected to be the fastest growing segment due to the introduction of scaffolds, which is one of the biomaterials used in 3D printing.

Key Findings of the Biomaterials Market

In 2015, metallic biomaterials segment contributed significantly to the revenue of the global market, and is projected to maintain this trend during the forecast period.
Among biomaterials, polymeric biomaterial segment is projected to grow rapidly registering a CAGR of 13.0% from 2016 to 2022.
Tissue engineering is projected to be the fastest growing application segment of biomaterials market with CAGR of 35.6% during analysis period.
North America is the leading region in the global biomaterials market.
North America and Europe jointly contributed over three-fourths share of the overall revenue in 2015.
Asia-Pacific biomaterials market is expected to be the fastest growing region during study period.
Chinese biomaterials market is expected to grow at a significant CAGR of 18.5% from 2016 to 2022.

In 2015, North America accounted for significant revenue share in the global biomaterials market, and is expected to maintain this trend throughout the forecast period. This is attributed to increase in prevalence of chronic and degenerative diseases coupled with growth in geriatric population, advent of innovative technologies, heavy funding by government agencies for R&D activities, and growing need to improve quality of life in North America. However, Asia-Pacific is expected to be the fastest growing region throughout 2022, owing to the presence of ample growth opportunities in terms of unmet medical needs for the treatment of cardiovascular, neurological & orthopedic disorders, increasing awareness about biomaterials advantages, and rising acceptance of advanced technologies in this region.

The key players in this market have adopted product development & launch as their key strategies to cater to the changing needs of the industry. Furthermore, companies have collaborated with other key players to develop cost-effective and technologically efficient technologies to strengthen their market positions. The development of novel products with innovative technologies and acquisition of companies possessing innovative technologies are the top strategies adopted by leading players in the market. The key players profiled in this report include Royal DSM, Wright Medical Group N.V., Corbion N.V., Zimmer Biomet Holdings, Inc., Bayer AG, Carpenter Technology Corporation, Covalon Technologies Ltd., Evonik Industries AG, BASF SE, Victrex plc., and Collagen Matrix, Inc.
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