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Industrial Biotechnology. Microorganisms. Advanced Biotechnology

  • ID: 3821073
  • Book
  • 792 Pages
  • John Wiley and Sons Ltd
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The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial–scale production.

Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi–purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high–value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses.

Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial–scale production.

Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi–purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high–value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. 

Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.
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List of Contributors XVII

About the Series Editors XXIX

Preface XXXI

Part I Industrial Biotechnology: From Pioneers to Visionary 1

1 History of Industrial Biotechnology 3Arnold L. Demain, Erick J. Vandamme, John Collins, and Klaus Buchholz

1.1 The Beginning of Industrial Microbiology 3

1.2 Primary Metabolites and Enzymes 7

1.3 The Antibiotic Era 16

1.4 The Biotechnology Era Between 1970 and 2015 27

1.5 How Pioneering Developments Led to Genetic Engineering 48

References 73

2 Synthetic Biology: An Emerging Approach for Strain Engineering 85Jie Sun and Hal Alper

2.1 Introduction 85

2.2 Basic Elements 86

2.3 Functional and Robust Modules 96

2.4 Microbial Communities 102

2.5 Conclusions and Future Prospects 104

Acknowledgments 104

References 104

3 Toward Genome–Scale Metabolic Pathway Analysis 111Jürgen Zanghellini, Matthias P. Gerstl, Michael Hanscho, Govind Nair, Georg Regensburger, Stefan Müller, and Christian Jungreuthmayer

3.1 Introduction 111

3.2 DD Method 114

3.3 Calculating Short EFMs in Genome–Scale Metabolic Networks 116

3.4 Conclusions 120

Acknowledgments 121

References 121

4 Cell–Free Synthetic Systems for Metabolic Engineering and Biosynthetic Pathway Prototyping 125Ashty S. Karim, Quentin M. Dudley, and Michael C. Jewett

4.1 Introduction 125

4.2 Background 127

4.3 The Benefits of Cell–Free Systems 129

4.4 Challenges and Opportunities in Cell–Free Systems 135

4.5 Recent Advances 140

4.6 Summary 141

Acknowledgments 141

References 142

Part II Multipurpose Bacterial Cell Factories 149

5 Industrial Biotechnology: Escherichia coli as a Host 151Matthew Theisen and James C. Liao

5.1 Introduction 151

5.2 E. coli Products 152

5.3 Rewiring Central Metabolism 165

5.4 Alternative Carbon Sources 167

5.5 E. coli Techniques and Concerns 169

5.6 Conclusions 170

References 171

6 Industrial Microorganisms: Corynebacterium glutamicum 183Judith Becker and Christoph Wittmann

6.1 Introduction 183

6.2 Physiology and Metabolism 185

6.3 Genetic Manipulation of Corynebacterium glutamicum  192

6.4 Systems Biology of Corynebacterium glutamicum  196

6.5 Application in Biotechnology 200

6.6 Conclusions and Perspectives 202

References 203

7 Host Organisms: Bacillus subtilis 221Hans–Peter Hohmann, Jan M. van Dijl, Laxmi Krishnappa, and Zoltán Prágai

7.1 Introduction and Scope 221

7.2 Identification of Genetic Traits Pertinent to Enhanced Biosynthesis of a Value Product 222

7.3 Traits to Be Engineered for Enhanced Synthesis and Secretion of Proteinaceous Products 225

7.4 Engineering of Genetic Traits in Bacillus subtilis  231

7.5 Genome Reduction 245

7.6 Significance of Classical Strain Improvement in Times of Synthetic Biology 247

7.7 Resource–Efficient B. subtilis Fermentation Processes 252

7.8 Safety of Bacillus subtilis  254

7.9 Bacillus Production Strains on the Factory Floor: Some Examples 258

Acknowledgments 280

References 280

8 HostOrganism: Pseudomonas putida 299Ignacio Poblete–Castro, José M. Borrero–de Acuña, Pablo I. Nikel, Michael Kohlstedt, and Christoph Wittmann

8.1 Introduction 299

8.2 Physiology and Metabolism 300

8.3 Genetic Manipulation 304

8.4 Systems Biology 307

8.5 Application in Biotechnology 311

8.6 Future Outlook 315

References 315

Part III Exploiting Anaerobic Biosynthetic Power 327

9 Host Organisms: Clostridium acetobutylicum/Clostridium beijerinckii and Related Organisms 329Frank R. Bengelsdorf, Anja Poehlein, Stefanie K. Flitsch, Sonja Linder, Bettina Schiel–Bengelsdorf, Benjamin A. Stegmann, Preben Krabben, Edward Green, Ying Zhang, Nigel Minton, and Peter Dürre

9.1 Introduction 329

9.2 Microorganisms 330

9.3 Bacteriophages 332

9.4 ABE Fermentation of Solvent–Producing Clostridium Strains 336

9.5 Genome–Based Comparison of Solvent–Producing Clostridium Strains 342

9.6 Regulation of Solvent Formation in C. acetobutylicum  345

9.7 Genetic Tools for Clostridial Species 346

9.8 Industrial Application of ABE Fermentation 353

Acknowledgments 355

References 355

10 Advances in Consolidated Bioprocessing Using Clostridium thermocellum and Thermoanaerobacter saccharolyticum 365Lee R. Lynd, Adam M. Guss, Michael E. Himmel, Dhananjay Beri, Chris Herring, Evert K. Holwerda, Sean J. Murphy, Daniel G. Olson, Julie Paye, Thomas Rydzak, Xiongjun Shao, Liang Tian, and Robert Worthen

10.1 Introduction  365

10.2 CBP Organism Development Strategies 366

10.3 Plant Cell Wall Solubilization by C. thermocellum  367

10.4 Bioenergetics of C. thermocellum Cellulose Fermentation 372

10.5 Metabolic Engineering 378

10.6 Summary and Future Directions 386

Acknowledgments 388

References 388

11 Lactic Acid Bacteria 395Luciana Ruiz–Rodríguez, Juliana Bleckwedel, Maria Eugenia Ortiz, Micaela Pescuma, and Fernanda Mozzi

11.1 Introduction 395

11.2 Fermented Foods 398

11.3 Industrially Relevant Compounds 406

11.4 Conclusions 434

Conflict of Interest 435

References 435

Contents to Volume 2

List of Contributors XV

About the Series Editors XXVII

Preface XXIX

Part IV Microbial Treasure Chests for High–Value Natural Compounds 453

12 Host Organisms: Myxobacterium 455Silke C. Wenzel and Rolf Müller

13 Host Organism: Streptomyces 487Oksana Bilyk and Andriy Luzhetskyy

Part V Extending the Raw Material Basis for Bioproduction 505

14 Extreme Thermophiles as Metabolic Engineering Platforms: Strategies and Current Perspective 507Andrew J. Loder, Benjamin M. Zeldes, Jonathan M. Conway, James A. Counts, Christopher T. Straub, Piyum A. Khatibi, Laura L. Lee, Nicholas P. Vitko, Matthew W. Keller, Amanda M. Rhaesa, Gabe M. Rubinstein, Israel M. Scott, Gina L. Lipscomb, Michael W.W. Adams, and Robert M. Kelly

15 Cyanobacteria as a Host Organism 581Fabienne Duchoud, Derrick S.W. Chuang, and James C. Liao

16 Host Organisms: Algae 605Elizabeth A. Specht, Prema S. Karunanithi, Javier A. Gimpel, William S. Ansari, and Stephen P. Mayfield

Part VI Eukaryotic Workhorses: Complex Cells Enable Complex Products 643

17 Host Organisms: Mammalian Cells 645Jennifer Pfizenmaier and Ralf Takors18 Industrial Microorganisms: Saccharomyces cerevisiae and other Yeasts 673Diethard Mattanovich, Brigitte Gasser, Michael Egermeier, Hans Marx, and Michael Sauer

19 Industrial Microorganisms: Pichia pastoris 687Diethard Mattanovich, Michael Sauer, and Brigitte Gasser

Index 715

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Christoph Wittmann
James C. Liao
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