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B-Cell Maturation Antigen (BCMA): Hot Target for Emerging Treatment Modalities

  • ID: 3844008
  • Report
  • Region: Global
  • 39 Pages
  • La Merie Publishing
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The highly restricted expression of B-cell maturation antigen (BCMA) to plasma cells and its role in the survival and growth for multiple myeloma cells makes BCMA a good potential target for enhanced immunotherapeutic strategies.

This report describes and analyzes the:

- Scientific rationale for BCMA-targeted therapies;
- Preclinical proof-of-concept of BCMA blockade;
- Clinical experience with BCMA-targeted therapies;
- The competitive landscape of BCMA-targeted treatment modalities;
- Profiles of anti-BCMA CAR T-cells, antibody-drug conjugate and T-cell redirecting bispecific antibodies:
- Profiles of companies involved in development of anti-BCMA therapy candidates.

Especially activity-enhanced antibodies and cells such as antibody-drug conjugates (ADCs) and T-cell redirecting bispecific antibodies as well as chimeric antigen receptor (CAR) T-cells, respectively, will benefit from the high target selectivity of BCMA to avoid on-target, off-tumor toxicity.

As a consequence, novel cellular and humoral BCMA-targeted treatment modalities have emerged and resulting product candidates entered first-in-human clinical evaluation. Further development candidates are undergoing IND-enabling studies.
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1. Target Background

2. Target Antigen Expression Profile

3. Preclinical Proof-of-Concept

4. Clinical Indications & Treatment Options

5. Clinical Experience with BCMA-Targeted Treatment Modalities

6. Treatment Modalities & Competitive Landscape

7. Drug & Cell Therapy Candidate Profiles
7.1. CAR T-Cells
7.2. Antibody-Drug Conjugate (ADC)
7.3. T-Cell Redirecting Antibodies

8. Company Profiles

9. References
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