Stress: Neuroendocrinology and Neurobiology: Handbook of Stress Series, Volume 2, focuses on neuroendocrinology, the discipline that deals with the way that the brain controls hormonal secretion, and in turn, the way that hormones control the brain. There have been significant advances in our understanding of neuroendocrine molecular and epigenetic mechanisms, especially in the way in which stress-induced hormonal and neurochemical changes affect brain plasticity, neuronal connectivity, and synaptic function.
The book features the topic of epigenetics, and how it enables stress and other external factors to affect genetic transmission and expression without changes in DNA sequence. Integrated closely with new behavioral findings and relevance to human disorders, the concepts and data in this volume offer the reader cutting-edge information on the neuroendocrinology of stress.
Volume 2 is of prime interest to neuroscientists, clinicians, researchers, academics, and graduate students in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, and in some areas of the social sciences, including stress and its management in the workplace.
- Includes chapters that offer impressive scope with topics addressing the neuroendocrinology and endocrinology of stress
- Presents articles carefully selected by eminent stress researchers and prepared by contributors that represent outstanding scholarship in the field
- Richly illustrated, with explanatory figures and tables
Part I. Neuroendocrine Control of the Stress Response 1. Stress Neuroendocrinology: Highlights and Controversies 2. Limbic Forebrain Modulation of Neuroendocrine Responses to Emotional Stress 3. Adrenergic Neurons in the CNS 4. Noradrenergic Control of Arousal and Stress 5. Evolution and Phylogeny of the Corticotropin-Releasing Factor Family of Peptides 6. Corticotropin-Releasing Factor and Urocortin Receptors 7. Tracking the Coupling of External Signals to Intracellular Programs Controlling Peptide Synthesis and Release in Hypothalamic Neuroendocrine Neurons 8. Neural Circuitry of Stress, Fear, and Anxiety: Focus on Extended Amygdala Corticotropin-Releasing Factor Systems 9. Vasopressin as a Stress Hormone 10. Adrenocorticotropic Hormone 11. The Role of MicroRNAs in Stress-Induced Psychopathologies 12. Stress Reactions Orchestrate Parasympathetic Functioning and Inflammation Under Diverse Cholinergic Manipulations 13. Early Life Stress- and Sex-Dependent Effects on Hippocampal Neurogenesis 14. Stress, Alcohol and Epigenetic Transmission 15. Stress, Panic, and Central Serotonergic Inhibition 16. Neuroendocrinology of Posttraumatic Stress Disorder: Focus on the HPA Axis 17. Stress and Major Depression: Neuroendocrine and Biopsychosocial Mechanisms 18. Telomeres and Early Life Stress
Part II. Endocrine Systems and Mechanisms in Stress Control 19. Stress, Glucocorticoids, and Brain Development in Rodent Models 20. Aging and Adrenocortical Factors 21. Aldosterone and Mineralocorticoid Receptors 22. Androgen Action and Stress 23. Angiotensin-Encyclopedia of Stress 24. Stress, Angiotensin, and Cognate Receptors 25. Annexin A1 26. Corticotropin-Releasing Factor Receptor Antagonists 27. Antidepressant Actions on Glucocorticoid Receptors 28. Lipids and Lipoproteins 29. Corticosteroid Receptors 30. Glucocorticoid Receptor: Genetics and Epigenetics in Veterans With PTSD 31. Stress Effects on Learning and Memory in Humans 32. Sex Differences in Chronic Stress: Role of Estradiol in Cognitive Resilience 33. Rapid and Slow Effects of Corticosteroid Hormones on Hippocampal Activity 34. 11ß-Hydroxysteroid Dehydrogenases 35. Stress, Insulin Resistance, and Type 2 Diabetes 36. Steroid Hydroxylases 37. Manipulating the Brain Corticosteroid Receptor Balance: Focus on Ligands and Modulators 38. Stress and the Central Circadian Clock 39. Nongenomic Effects of Glucocorticoids: Translation From Physiology to Clinic
Part III. Diurnal, Seasonal, and Ultradian Systems 40. Circadian Rhythm Effects on Cardiovascular and Other Stress-Related Events 41. Seasonal Variation in Stress Responses 42. Seasonal Rhythms 43. Ultradian Rhythms
George Fink is a neuroendocrinologist, neuropharmacologist and psychopharmacologist. He is Professorial Research Fellow at the Florey Institute for Neuroscience and Mental Health, Melbourne University at which he is also an Honorary Professor. He is renowned for his research in reproductive neuroendocrinology, the neuroendocrine control of stress, positive and negative hormonal feedback control in neuroendocrine loops, and the effect of sex hormones on central neurotransmission.
He was founding editor of the Encyclopedia of Stress (2000 and 2007) and editor of several other volumes on stress.