Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic.
Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications.
Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics.
- Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery
- Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues
- Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab
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Chapter 1. Andrographolide: A Molecule of Antidiabetic Promise
Chapter 2. Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products
Chapter 3. Identification and Extraction of Antidiabetic Antioxidants from Natural Sources
Chapter 4. Glucose Transporter 4 Translocation Activators From Nature
Chapter 5. Carbohydrate-Based Antidiabetic Agents From Nature
Chapter 6. Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues
Chapter 7. Prediction of Prediabetes and Its Prevention by Functional Food Compounds
Chapter 8. Immunomodulators in Prophylaxis and Therapy of Type-1 Diabetes
Chapter 9. ?-Glucosidase Enzyme Inhibitors From Natural Products
Chapter 10. Treasures of Indigenous Indian Herbal Antidiabetics: An Overview
Goutam Brahmachari is a professor of organic chemistry at Visva-Bharati, India, and teaches courses in organic chemistry, natural products chemistry, synthetic organic chemistry, and physical methods in organic chemistry. In addition to over 20 years of teaching and research experience, he is a Fellow of the Royal Society of Chemistry, a Who's Who in the World Listee, and a recipient of Academic Brilliance Award (2015) for Excellence in Research and the Dr. Kalam Best Teaching Faculty Award (2017). Prof. Brahmachari serves as journal referee, editor-in-chief, associate editor, guest editor, and Editorial Advisory Board Member for several international journals, book publishers, and research funding agencies. He currently has 200 publications in the fields of organic and medicinal chemistry, including 22 books and over 40 book chapters, published by internationally reputed publishers.