Accurate assessment of human drug toxicity is a major challenge in the pharmaceutical industry. Drug metabolism and toxicology are two scientific disciplines that traditionally have been considered independently. For instance, in drug development, drug candidates are evaluated for properties in these two disciplines in different departments. It is now becoming apparent that the two disciplines are closely related in terms of safety evaluation.
Transporters and Drug–Metabolizing Enzymes in Drug Toxicity provides a comprehensive and up–to–date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity. It brings together the scientific disciplines of drug metabolism and toxicology, with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. In addition, the author describes promising experimental approaches to accurately assess human drug toxicity via the incorporation of human–specific drug metabolism in toxicity assays.
Offering a valuable resource for those scientific professionals and researchers involved with drug development, pharmacology, and toxicology; Transporters and Drug–Metabolizing Enzymes in Drug Toxicity features key benefits that include:
Unites both the metabolism and transporter components of drug toxicity two aspects not normally connected and the latter often neglected
Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transportersDescribes methods to investigate the role drug metabolizing enzymes and transporters in drug toxicity
Drug Drug Interactions in Pharmaceutical Development and co–editor of
Enzyme Inhibition in Drug Discovery and Development: The Good and the Bad, both published by Wiley.