Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging.
The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.
- Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field
- Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine
- Written at a verbal and technical level that can be understood by scientists and college students
- Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials
1. An Overview of Epigenetics
SECTION I: Molecular Mechanisms of Epigenetics 2. Mechanisms of DNA Methylation 3. Molecular Mechanisms of Histone Modification 4. The Epigenetics of Non-coding RNA
SECTION II: Additional Epigenetic Processes 5. Prions in Epigenetic Inheritance 6. Chromosomal Position Effects 7. Polycomb-group Proteins and Epigenetics
SECTION III: Epigenetic Technology 8. Analyses of Gene-specific DNA Methylation 9. Methods for Assessing Genome-wide DNA Methylation 10. Determination of Histone Modifications of Specific Genes 11. Analyses of Genome-wide Histone Modifications 12. Techniques for Genome-wide Expression of Non-coding RNA 13. Computational Epigenetics
SECTION IV: Model Organisms of Epigenetics 14. Epigenetics of Lower Organisms 15. Drosophila Epigenetics 16. Models of Mouse Epigenetic Inheritance 17. Plant Epigenetics
SECTION V: Metabolism and Epigenetics 18. Metabolic Effects on DNA Methylation 19. Metabolism and Chromatin Dynamics
SECTION VI: Functions of Epigenetics 20. Epigenetics, Stem Cells and Cellular Differentiation 21. Regeneration Epigenetics 22. Epigenetics of X-chromosome Inactivation 23. Genomic Imprinting 24. Epigenetics of Memory Processes 25. Transgenerational Epigenetics 26. Aging Epigenetics
SECTION VII: Evolutionary Epigenetics 27. Evolution of Epigenetic Mechanisms 28. Adaptive Evolution and Epigenetics
SECTION VIII: Epigenetic Epidemiology 29. The Effects of Diet on Epigenetic Processes 30. Environmental Agents and Epigenetic Effects 31. Impact of Infective Agents on the Epigenome 32. Population Pharmacoepigenomics
SECTION IX: Epigenetics and Human Disease 33. Cancer Epigenetics 34. The Role of Epigenetics in Immune Disorders 35. Epigenetics of Brain Disorders 36. The Epigenetics of Metabolic Diseases 37. Imprinting Defects in Humans
SECTION X: Epigenetic Therapy 38. DNA Demethylating Agents in Clinical Medicine 39. Clinical Applications of Histone Deacetylase Inhibitors 40. Combination Epigenetic Therapy
SECTION XI: The Future of Epigenetics 41. New Directions for Epigenetic Research
Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol's research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women's Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biotechnology and Clinical Epigenetics. He is also a contributing Editor of Lewin's GENES X classic textbook. Over 25 of the publications from Dr. Tollefsbol's laboratory have received national or international accolades such as best paper award, selection for press release by the journal editors and featured on the journal homepage. Dr. Tollefsbol has been invited to give presentations on his research in many countries including Germany, China, Italy, Switzerland, France and The Netherlands as well as at various leading institutions in the US such as Harvard Medical School, Tufts University and the University of California at San Francisco. His research has received considerable media attention both nationally and internationally through television, newspaper and radio venues and has been highlighted in eScience News and ScienceDaily. He has ten books which have been published or are in progress and a recent book on "Epigenetics of Aging that Dr. Tollefsbol co-authored and edited was highlighted in Nature.