EpiCast Report: Ulcerative Colitis - Epidemiology Forecast to 2025

  • ID: 4051399
  • Drug Pipelines
  • 101 pages
  • GlobalData
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Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by long-lasting inflammation and ulcers (sores) in the lining of the digestive tract. In UC, because of an abnormal response of the body’s immune system, the lining of the colon becomes inflamed and develops tiny open sores, or ulcers, that produce pus and mucous. This causes abdominal discomfort and frequent emptying of the colon. UC is a type of IBD, not to be confused with irritable bowel syndrome (IBS), a disorder that affects the muscle contractions of the colon and is not characterized by intestinal inflammation.

UC commonly affects teenagers and young adults, and can result in poor development and growth; nonetheless, the disease can also occur in children and older individuals (CCFA, 2016a). Unlike the other form of IBD-Crohn’s disease (CD), which has similar symptoms but can occur anywhere in the digestive tract, with ulceration deep into the tissues-UC is limited to the colon and has less frequent complications, such as rupture of the colon, bleeding from deep ulcerations, and failure of treatment response.

In the 7MM, epidemiologists forecast that the diagnosed incident cases of UC will increase from 86,509 cases in 2015 to 95,864 cases in 2025, at an annual growth rate (AGR) of 1.08%. The US will have the highest number of diagnosed incident cases of UC over the forecast period, while Spain will have the lowest.

Epidemiologists forecast that the undiagnosed prevalent cases of UC will increase from 556,966 cases in 2015 to 614,036 cases in 2025, at an AGR of 1.02%. The US will have the highest number of undiagnosed prevalent cases of UC over the forecast period, while Spain will have the lowest.

The report “EpiCast Report: Ulcerative Colitis - Epidemiology Forecast to 2025” provide an overview of the risk factors and global trends of UC in the seven major markets (7MM) (US, France, Germany, Italy, Spain, UK, and Japan). It includes a 10-year epidemiological forecast for the diagnosed incident cases, diagnosed prevalent cases, undiagnosed prevalent cases, and total prevalent cases of UC segmented by sex and age in these seven markets. The diagnosed incident cases are further segmented by stage at diagnosis and severity grading. The diagnosed prevalent cases are further segmented by severity grading. Additionally, autoimmune comorbidities, colectomy due to failure of medical management, and mortality due to complications of UC among the diagnosed prevalent cases of UC are also included in this analysis. Furthermore, the report includes diagnosed incident cases and diagnosed prevalent cases of indeterminate colitis (IC) for both sexes and all ages in the 7MM.
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1.1 List of Tables

1.2 List of Figures

2 Epidemiology

2.1 Disease Background

2.2 Risk Factors and Comorbidities

2.3 Global Trends

2.3.1 Incidence

2.3.2 Prevalence

2.4 Forecast Methodology

2.4.1 Sources Used

2.4.2 Forecast Assumptions and Methods

2.4.3 Sources Not Used

2.5 Epidemiological Forecast for UC (2015-2025)

2.5.1 Diagnosed Incident Cases of UC

2.5.2 Diagnosed Prevalent Cases of UC

2.5.3 Undiagnosed Prevalent Cases of UC

2.5.4 Total Prevalent Cases of UC

2.5.5 Diagnosed Incident Cases of IC

2.5.6 Diagnosed Prevalent Cases of IC

2.6 Discussion

2.6.1 Epidemiological Forecast Insight

2.6.2 Limitations of the Analysis

2.6.3 Strengths of the Analysis

3 Appendix

3.1 Bibliography

3.2 Physicians and Specialists Included in this Study

3.3 About the Authors

3.3.1 Epidemiologists

3.3.2 Reviewers

3.3.3 Global Director of Therapy Analysis and Epidemiology

3.4 About

3.5 About EpiCast

3.6 Disclaimer

1.1 List of Tables

Table 1: Risk Factors and Comorbidities for UC and IBD

Table 2: Incidence of UC in the 5EU

Table 3: Prevalence of UC in Italy, Spain, and the UK

Table 4: 7MM, Sources Used to Forecast the Diagnosed Incident Cases of UC

Table 5: 7MM, Sources Used to Forecast the Diagnosed Prevalent Cases of UC

Table 6: 7MM, Sources Used to Forecast Undiagnosed Prevalent Cases of UC

Table 7: 7MM, Sources Used to Forecast the Total Prevalent Cases of UC

Table 8: 7MM, Sources Used to Forecast the Diagnosed Incident Cases of UC by Stage at Diagnosis

Table 9: 7MM, Sources of Epidemiological Data Used to Forecast the Diagnosed Incident/Prevalent Cases of UC by Severity

Table 10: 7MM, Sources of Epidemiological Data used to Forecast Mortality Due to CRC and TMC Among the Diagnosed Prevalent Cases of UC

Table 11: 7MM, Sources Used to Forecast Autoimmune Comorbidities Among the Diagnosed Prevalent Cases of UC

Table 12: 7MM, Sources Used to Forecast UC Cases Requiring Colectomy Among the Diagnosed Prevalent Cases of UC Due to Failure of Medical Management

Table 13: 7MM, Sources Used to Forecast the Diagnosed Incident Cases of IC

Table 14: 7MM, Sources Used to Forecast the Diagnosed Prevalent Cases of IC

Table 15: 7MM, Sources Not Used in Epidemiological Analysis of UC

Table 16: 7MM, Diagnosed Incident Cases of UC, Both Sexes, All Ages, N, Selected Years 2015-2025

Table 17: 7MM, Age-Specific Diagnosed Incident Cases of UC, Both Sexes, N (Row %), 2015

Table 18: 7MM, Sex-Specific Diagnosed Incident Cases of UC, All Ages, N (Row %), 2015

Table 19: 7MM, Diagnosed Prevalent Cases of UC, Both Sexes, All Ages, N, Selected Years, 2015-2025

Table 20: 7MM, Age-Specific Diagnosed Prevalent Cases of UC, Both Sexes, N (Row %), 2015

Table 21: 7MM, Sex-Specific Diagnosed Prevalent Cases of UC, All Ages, N (Row %), 2015

Table 22: 7MM, Undiagnosed Prevalent Cases of UC, Both Sexes, All Ages, N, Select Years, 2015-2025

Table 23: 7MM, Age-Specific Undiagnosed Prevalent Cases of UC, Both Sexes, N (Row %), 2015

Table 24: 7MM, Sex-Specific Undiagnosed Prevalent Cases of UC, All Ages, N (Row %), 2015

Table 25: 7MM, Total Prevalent Cases of UC, Both Sexes, All Ages, N, Selected Years, 2015-2025

Table 26: 7MM, Age-Specific Total Prevalent Cases of UC, Both Sexes, N (Row %), 2015

Table 27: 7MM, Sex-Specific Total Prevalent Cases of UC, All Ages, N (Row %), 2015

Table 28: 7MM, Diagnosed Incident Cases of IC, Both Sexes, All Ages, N, Selected Years, 2015-2025

Table 29: 7MM, Diagnosed Prevalent Cases of IC, Both Sexes, All Ages, N, Selected Years, 2015-2025

1.2 List of Figures

Figure 1: 7MM, Diagnosed Incident Cases of UC, Both Sexes, All Ages, Selected Years, 2015-2025

Figure 2: 7MM, Age-Specific Diagnosed Incident Cases of UC, Both Sexes, All Ages, N, 2015

Figure 3: 7MM, Sex-Specific Diagnosed Incident Cases of UC, All Ages, N, 2015

Figure 4: 7MM, Age-Standardized Diagnosed Incidence of UC (Cases per 100,000 Population), All Ages, Both Sexes, N, 2015

Figure 5: 7MM, Diagnosed Incident Cases of UC Segmented by Stage at Diagnosis, Both Sexes, All Ages, N, 2015

Figure 6: 7MM, Diagnosed Incident Cases of UC Segmented by Severity, Both Sexes, All ages, N, 2015

Figure 7: 7MM, Diagnosed Prevalent Cases of UC, Both Sexes, All Ages, Selected Years, 2015-2025

Figure 8: 7MM, Age-Specific Diagnosed Prevalent Cases of UC, Both Sexes, N, 2015

Figure 9: 7MM, Sex-Specific Diagnosed Prevalent Cases of UC, All Ages, N, 2015

Figure 10: 7MM, Age-Standardized Diagnosed Prevalence of UC, All Ages, Both Sexes, %, 2015

Figure 11: 7MM, Diagnosed Prevalent Cases of UC Segmented by Severity, Both Cases, All Ages, N, 2015

Figure 12: 7MM, Mortality Due to Complications Among the Diagnosed Prevalent Cases of UC, Both Sexes, All Ages, N, 2015

Figure 13: 7MM, Colectomy Due to Failure of Medical Management Among the Diagnosed Prevalent Cases of UC, Both Sexes, All Ages, N, 2015

Figure 14: 7MM. Comorbidities Among the Diagnosed Prevalent Cases of UC, Both Sexes, All Ages, N, 2015

Figure 15: 7MM, Undiagnosed Prevalent Cases of UC, Both Sexes, All Ages, Selected Years, N, 2015-2025

Figure 16: 7MM, Age-Specific Undiagnosed Prevalent Cases of UC, Both Sexes, N, 2015

Figure 17: 7MM, Sex-Specific Undiagnosed Prevalent Cases of UC, All Ages, N, 2015

Figure 18: 7MM, Age-Standardized Undiagnosed Prevalence of UC, All Ages, Both Sexes, %, 2015

Figure 19: 7MM, Total Prevalent Cases of UC, Both Sexes, All Ages, Selected Years, N, 2015-2025

Figure 20: 7MM, Age-Specific Total Prevalent Cases of UC, Both Sexes, N, 2015

Figure 21: 7MM, Sex-Specific Total Prevalent Cases of UC, All Ages, N, 2015

Figure 22: 7MM, Age-Standardized Total Prevalence of UC, All Ages, Both Sexes, %, 2015

Figure 23: 7MM, Diagnosed Incident Cases of IC, Both Sexes, All Ages, Selected Years, N, 2015-2025

Figure 24: 7MM, Diagnosed Prevalent Cases of IC, Both Sexes, All Ages, Selected Years, N, 2015-2025
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