PD-1 and PD-L1 Inhibitors - Competitive Landscape, Pipeline and Market Analysis, 2017

  • ID: 4060531
  • Report
  • Region: Global
  • 311 Pages
  • DelveInsight
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Provides Information on the Therapeutic Development Based on PD-1 and PD-L1 Inhibitors Mechanism of Action Dealing With Around 20+ Active Pipeline Drugs
PD-1 and PD-L1 Inhibitors - Competitive Landscape, Pipeline and Market Analysis, 2017 provides comprehensive insights about marketed and pipeline drugs across this Mechanism of action. Key objective of the report is to establish the understanding for all the marketed and pipeline drugs that fall under PD-1 and PD-L1 Inhibitors.

This report provides comprehensive insights across PD-1 and PD-L1 Inhibitors including detailed Marketed product profiles. The report has information on detailed pipeline portfolio including Phase III, Phase II, Phase I, Pre-Clinical and Discovery Products. With more than 50 products in various stages of development, the pipeline seems encouraging which has made PD-1 and PD-L1 the most talked about Immuno-oncology target.

There are 50+products in pipeline and 5 products have been marketed so far. The focus is majorly on the antibody-based interventions targeting programmed cell death protein 1 (PD-1) on T lymphocytes and its principal ligand (PD-L1) on tumor cells to restore latent anti-tumor immunity.

Key Coverage and Benefits:

1. In-depth analysis of the 50+ pipeline assets.
2. Pipeline landscape provides a deep dive into clinical, pre-clinical and discovery molecules.
3. Extensive coverage of Technology implemented by companies in this space.
4. Licensing and Deals related to PD-1 and PD-L1 inhibitors are also covered.
5. Insights on marketed products including detailed marketed product profiles. Also includes Historical and Five years forecasted sales for Marketed products (Opdivo, Keytruda, Tecentriq, Bavencio and Imfinzi).
6. Extensive coverage of ASCO 2017 updates and related insights.
7. Therapeutic assessment by molecule type, route of administration, monotherapy and combination products.
8. Detailed information on inactive projects in the pipeline for PD-1 & PD-L1 Inhibitors.
9. Information to identify emerging players with potentially lucrative products.

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Executive Summary
Technology
Product Type by Specificity
ASCO 2017 Highlights
Programmed Death 1 (PD-1)
Programmed Death Ligand 1 (PD-L1)
Role of PD-1 and PD-L1 pathways
MOA of PD-1 and PD-L1 inhibitors
Significance of PD-1 and PD-L1 inhibitors
PD-1 and PD-L1 Active Therapy Areas & Epidemiology
Biomarkers - PD-1 and PD-L1 inhibitors
Major issues with PD-L1 as a Biomarker
Market Overview
Comparative Analysis of Pipeline & Marketed Products
Marketed Drug Candidate Profiles
ASCO 2017 Updates
Pipeline Therapeutics
Comparative Analysis
Late Stage Products (Phase III)
Comparative Analysis
Late Stage(Phase III) ProductProfiles
Mid Stage Products (Phase II)
Comparative Analysis
Mid Stage(Phase II) ProductProfiles
Early Stage Products (Phase I and IND)
Comparative Analysis
Early Stage(Phase I and IND) Product Profiles
Pre-clinical and Discovery Stage Products
Comparative Analysis
Pre-clinical and Discovery Stage Product Profiles
Therapeutic Assessment: Active Products
Assessment by Monotherapy Products
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Dormant Products
Comparative Analysis
Appendix

List of Tables
Table 1: Marketed and Pipeline products for PD-1 and PD-L1 Inhibitors
Table 2: Total Drugs for PD-1 and PD-L1 Inhibitors
Table 3: Late Stage Products (Phase III)
Table 4: Mid Stage Products (Phase II)
Table 5: Early Stage Products (Phase I and IND)
Table 6: Pre-clinical and Discovery Stage Products
Table 7: Assessment by Monotherapy Products
Table 8: Assessment by Combination Products
Table 9: Assessment by Route of Administration
Table 10: Assessment by Stage and Route of Administration
Table 11: Assessment by Molecule Type
Table 12: Assessment by Stage and Molecule Type
Table 13: Dormant Products

List of Figures
Figure 1: Illustration: T cell interaction with cancer
Figure 2: Illustration: PD-L1/PD-1 Pathway
Figure 3: Illustration: MOA of PD-1 and PD-L1
Figure 4: Marketed and Pipeline products for PD-1 and PD-L1 Inhibitors
Figure 5: Total Drugs for PD-1 and PD-L1 Inhibitors
Figure 6: Late Stage Products (Phase III)
Figure 7: Mid Stage Products (Phase II)
Figure 8: Early Stage Products (Phase I)
Figure 9: Pre-clinical Stage and Discovery Products
Figure 10: Assessment by Monotherapy Products
Figure 11: Assessment by Route of Administration
Figure 12: Assessment by Stage and Route of Administration
Figure 13: Assessment by Molecule Type
Figure 14: Assessment by Stage and Molecule Type
Figure 15: Dormant Products
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