Global Antibacterial Drugs Market to 2022 - Vaccines Retain Market Prominence While Pipeline Offers Innovative Approaches to Tackling Antimicrobial Resistance

  • ID: 4061483
  • Report
  • Region: Global
  • 177 Pages
  • GBI Research
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Antibacterial Drug Market will Hit $35.6 Billion by 2022, as Efforts Increase to Tackle Antimicrobial Resistance

FEATURED COMPANIES

  • Allergan
  • AstraZeneca
  • Bayer
  • Cempra
  • GlaxoSmithKline
  • Insmed
  • MORE
Bacteria are a major class of prokaryotic micro-organism and are broadly classified as either gram-positive bacteria, which retain their color under gram-staining and have an inner plasma membrane and a thick peptidoglycan layer, or gram-negative bacteria, which lose their color under gram-staining and have both an inner and outer plasma membrane with a thin peptidoglycan wall in-between these structures.

Antibacterial usage is expected to decrease slightly in developed countries as a result of an increasing pressure to combat antimicrobial resistance (AMR). Despite this, the antibacterial drug market is forecast to grow from USD27.7 Billion in 2015 to USD35.6 Billion in 2022, at a compound annual growth rate (CAGR) of 3.97%.

Antibacterial market is dominated by three players: Pfizer, GlaxoSmithKline (GSK) and Merck & Co. Pfizer is expected to maintain its lead in the market in terms of revenue and market share until 2022, while GSK and Merck & Co. are expected to experience substantial growth within antibacterial over the forecast period, helping to drive the growth of the market overall. A large part of this growth is expected to come from the entry into the market of several companies, including Allergan, Cempra and Insmed.

Global antibacterial vaccination market is expected to experience healthy growth across the forecast period due to rising profits for several classes of drugs. Vaccines will still be the leading revenue-generating drugs in the market in 2022, despite the influx of new protein synthesis inhibitors and the release of several new cell-wall synthesis inhibitors.

As per Thomas Jarratt, Analyst, “In an attempt to tackle antimicrobial resistance, many companies are investing in the development of products active against bacteria that are known to be resistant to established classes of antibacterials. The use of protein synthesis inhibitors, for example, is expected to increase dramatically over the forecast period as a result of their effectiveness in treating drug-resistant bacterial infections.”

The report “Global Antibacterial Drugs Market to 2022 - Vaccines Retain Market Prominence While Pipeline Offers Innovative Approaches to Tackling Antimicrobial Resistance” provides an introduction to the antibacterial market, including disease epidemiology, symptoms, etiology, pathophysiology, co-morbidities and complications, diagnosis and prognosis.

In depth, this report provides the following:
  • Provides an overview of the landscape for antibacterial marketed products, including product profiles of key marketed products and revenue projections for each of these drugs.
  • Analyzes the antibacterial pipeline, detailing, among other parameters, drug distribution by stage of development, molecule type and mechanism of action, plus an analysis of the key indications in the pipeline: pneumonia, TB, sepsis and methicillin-resistant staphylococcus aureus (MRSA).
  • Presents forecast projections to 2022 on a global level, with forecasts also provided for the US, plus aggregate revenue forecasts of the top five EU markets (the UK, France, Germany, Italy and Spain) and Japan.
  • Assesses the company landscape in bacterial infections, with an analysis of the key players, the types of company involved in this disease cluster, and whether this disease cluster comprises a large proportion of each company’s pipeline portfolio and total revenue.
  • Analysis about trends in co-development and licensing deals relating to antibacterial products.
Companies mentioned in this report: Merck & Co, GlaxoSmithKline, Pfizer.
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FEATURED COMPANIES

  • Allergan
  • AstraZeneca
  • Bayer
  • Cempra
  • GlaxoSmithKline
  • Insmed
  • MORE

1 Table of Contents

2 Introduction
2.1 Disease Cluster Introduction
2.2 Symptoms
2.2.1 Pneumonia
2.2.2 MRSA
2.2.3 Sepsis
2.2.4 Tuberculosis
2.3 Diagnosis
2.3.1 Pneumonia
2.3.2 MRSA
2.3.3 Sepsis
2.3.4 Tuberculosis
2.4 Etiology and Pathophysiology
2.4.1 Pneumonia
2.4.2 MRSA
2.4.3 Sepsis
2.4.4 Tuberculosis
2.5 Epidemiology
2.5.1 Pneumonia
2.5.2 MRSA
2.5.3 Sepsis
2.5.4 Tuberculosis
2.6 Comorbidities and Complications
2.6.1 Pneumonia
2.6.2 MRSA
2.6.3 Sepsis
2.6.4 Tuberculosis
2.7 Prognosis
2.7.1 Pneumonia
2.7.2 MRSA
2.7.3 Sepsis
2.7.4 Tuberculosis
2.8 Treatment
2.8.1 Beta-lactams
2.8.2 Protein Synthesis inhibitors
2.8.3 Vaccines
2.8.4 Other Classes of Antibacterial Therapy

3 Key Marketed Products
3.1 Overview
3.2 Cubicin (daptomycin) - Merck & Co
3.3 Augmentin - GlaxoSmithKline
3.4 Prevnar 13 - Pfizer
3.5 Infanrix - GlaxoSmithKline
3.6 Boostrix - GlaxoSmithKline
3.7 Zerbaxa - Merck and Co
3.8 Bexsero - GlaxoSmithKline
3.9 Zyvox - Pfizer
3.10 Conclusion

4 Pipeline Landscape Assessment
4.1 Overview
4.2 Pipeline Development Landscape
4.3 Mechanisms of Action in Pipeline
4.4 Clinical Trial Landscape
4.4.1 Failure Rate by Stage of Development, Indication and Molecule Type
4.4.2 Clinical Trial Duration by Stage of Development, Indication, and Molecule Type
4.4.3 Clinical Trial Size by Stage of Development, Indication and Molecule Type
4.4.4 Aggregate Clinical Program Size by Stage of Development, Indication and Molecule Type
4.5 Conclusion
4.6 Assessment of Key Pipeline Products
4.6.1 Solithera - Cempra
4.6.2 Arikace - Insmed
4.6.3 Cadazolid - Actelion
4.6.4 Plazomicin (plazomicin sulfate) - Achaogen
4.6.5 V114 - Merck & Co.
4.6.6 Suvratoxumab (MEDI4893) - MedImmune
4.6.7 Pf-06290510 (SA4Ag vaccine) - Pfizer
4.6.8 PF-06425090 - Pfizer
4.6.9 Conclusion

5 Multi-Scenario Market Forecast to 2022
5.1 Overall Market Size
5.2 Generic Penetration
5.3 Revenue Forecast by Mechanism of Action
5.3.1 Immune Response
5.3.2 Bacterial Cell Wall Disruptor/Inhibitor
5.3.3 Protein Synthesis Inhibitors
5.3.4 DNA Inhibitors
5.3.5 Multiple Mechanisms of Action

6 Company Analysis and Positioning
6.1 Revenue and Market Share Analysis by Company
6.1.1 Pfizer - Will it Maintain its Position as Market Leader?
6.1.2 GlaxoSmithKline - Will Revenues for Key Products Continue to Grow Over Forecast Period?
6.1.3 Merck & Co - How Will Key Approvals and Patent Expiries Affect Revenue?
6.1.4 Allergan - Revenues to Rise Rapidly Following Market Entry
6.1.5 Cempra - Set to Enter the Market in 2017
6.1.6 Insmed - Set to Enter the Market in 2018
6.1.7 Otsuka - How Will the Approval of Deltyba Affect Otsuka’s Market Share?
6.1.8 Roche - Revenues to Continue to Decline Due to Lack of Pipeline Products
6.1.9 Bayer - Steady Decline as All Products Off-Patent
6.1.10 AstraZeneca - Set to Revitalize its Position within the Market
6.2 Company Landscape
6.3 Marketed and Pipeline Portfolio Analysis

7 Strategic Consolidations
7.1 Licensing Deals
7.1.1 Deals by Region, Value and Year
7.1.2 Deals by Indication
7.1.3 Deals by Stage of Development and Value
7.1.4 Deals by Molecule Type, Mechanism of Action and Value
7.1.5 Licensing Deals Valued Above $100m
7.2 Co-development Deals
7.2.1 Deals by Region, Value and Year
7.2.2 Deals by Indication
7.2.3 Deals by Stage of Development and Value
7.2.4 Deals by Molecule Type and Value
7.2.5 Co-development Deals Valued Above $100m

8 Appendix
8.1 References
8.2 Table of all Pipeline Products
8.3 Table of Epidemiology Forecast
8.4 Abbreviations
8.5 Methodology
8.5.1 Coverage
8.5.2 Secondary Research
8.5.3 Market Size and Revenue Forecasts
8.5.4 Pipeline Analysis
8.5.5 Competitive Landscape

List of Tables

Table 1: Antibacterial Drug Market, Global, Key Marketed Products and Approved Indications, 2016
Table 2: Antibacterial Drug Market, Global, Approved Indications for Cubicin, 2016
Table 3: Antibacterial Drug Market, Global, Approved Indications for Augmentin, 2016
Table 4: Antibacterial Drug Market, Global, Approved Indications for Prevnar 13, 2016
Table 5: Antibacterial Drug Market, Global, Approved Indications for Infanrix, 2016
Table 6: Antibacterial Drug Market, Global, Approved Indications for Boostrix, 2016
Table 7: Antibacterial Drug Market, Global, Approved Indications for Zerbaxa, 2016
Table 8: Antibacterial Drug Market, Global, Approved Indications for Bexsero, 2016
Table 9: Antibacterial Drug Market, Global, Approved Indications for Zyvox, 2016
Table 10: Antibacterial Drug Market, Global, Annual Revenue Forecast for Key Products ($m), 2015-2022
Table 11: Antibacterial Drug Market, Global, Usage of Generics Across Key Indications, 2015
Table 12: Antibacterial Drug Market, Global, Forecast Revenues by Company, 2015-2022
Table 13: Antibacterial Drug Market, Global, Licensing Deals Valued Above $100m, 2006-2016
Table 14: Antibacterial Drug Market, Global, Co-development Deals Above $100m, 2006-2016
Table 15: Antibacterial Drug Market, Global, Pipeline Products, Discovery, 2016
Table 16: Antibacterial Drug Market, Global, Pipeline Products, Preclinical, 2016
Table 17: Antibacterial Drug Market, Global, Pipeline Products, IND/CTA-filed, 2016
Table 18: Antibacterial Drug Market, Global, Pipeline Products, Phase I, 2016
Table 19: Antibacterial Drug Market, Global, Pipeline Products, Phase II, 2016
Table 20: Antibacterial Drug Market, Global, Pipeline Products, Phase III, 2016
Table 21: Antibacterial Drug Market, Global, Pipeline Products,Pre-registration, 2016
Table 22: Antibacterial Drug Market, Global, Pipeline Products, Unknown, 2016
Table 23: Antibacterial Drug Market, Prevalence Patterns for Pneumonia, 2015-2022
Table 24: Antibacterial Drug Market, Vaccinations Patterns for Pneumonia, 2015-2022
Table 25: Antibacterial Drug Market, Prevalence Patterns for Sepsis, 2015-2022
Table 26: Antibacterial Drug Market, Prevalence Patterns for Tuberculosis, 2015-2022
Table 27: Abbreviations

List of Figures

Figure 1: Antibacterial Drug Market, Global, Epidemiology Patterns for Pneumonia Incidence, 2015-2022
Figure 2: Antibacterial Drug Market, Global, Epidemiology Patterns for Pneumococcal Vaccinations, 2015-2022
Figure 3: Antibacterial Drug Market, Global, Epidemiology Patterns for Sepsis, 2015-2022
Figure 4: Antibacterial Drug Market, Global, Epidemiology Patterns for Tuberculosis, 2015-2022
Figure 5: Antibacterial Drug Market, Global, Annual Revenue for Cubicin ($m), 2006-2022
Figure 6: Antibacterial Drug Market, Global, Annual Revenue for Augmentin ($m), 2006-2022
Figure 7: Antibacterial Drug Market, Global, Annual Revenue for Prevnar 13 ($bn), 2009-2022
Figure 8: Antibacterial Drug Market, Global, Annual Revenue for Infanrix ($bn), 2006-2022
Figure 9: Antibacterial Drug Market, Global, Annual Revenue for Boostrix ($m), 2006-2022
Figure 10: Antibacterial Drug Market, Global, Annual Revenue for Zerbaxa ($m), 2016-2022
Figure 11: Antibacterial Drug Market, Global, Annual Revenue for Bexsero ($m), 2015-2022
Figure 12: Antibacterial Drug Market, Global, Annual Revenue for Zyvox ($bn), 2006-2022
Figure 13: Antibacterial Drug Market, Global, Overall Pharmaceutical Industry Pipeline by Therapy Area, 2016
Figure 14: Antibacterial Drug Market, Global, Pipeline by Stage of Development and Molecule Type, 2016
Figure 15: Antibacterial Drug Market, Global, Pipeline, Key Indications by Stage of Development, 2016
Figure 16: Antibacterial Drug Market, Global, Pipeline, Key Indications Molecule Type, 2016
Figure 17: Antibacterial Drug Market, Global, Overall Pipeline by Mechanism of Action, 2016
Figure 18: Antibacterial Drug Market, Global, Pipeline by Mechanism of Action and Stage of Development, 2016
Figure 19: Antibacterial Drug Market, Global, Pipeline for Key Bacterial Indications by Mechanism of Action, 2016
Figure 20: Antibacterial Drug Market, Global, Clinical Trial Failure Rates by Stage of Development (%), 2006-2016
Figure 21: Antibacterial Drug Market, Global, Clinical Trial Failure Rates by Stage of Development and Indication (%), 2006-2016
Figure 22: Antibacterial Drug Market, Global, Clinical Trial Failure Rates by Stage of Development and Molecule Type (%), 2006-2016
Figure 23: Antibacterial Drug Market, Global, Clinical Trial Failure Rates by Stage of Development and Mechanism of Action (%), 2006-2016
Figure 24: Antibacterial Drug Market, Global, Clinical Trial Duration by Stage of Development (months), 2006-2016
Figure 25: Antibacterial Drug Market, Global, Clinical Trial Duration by Stage of Development and Indication (months), 2006-2016
Figure 26: Antibacterial Drug Market, Global, Clinical Trial Duration by Stage of Development and Molecule Type (months), 2006-2016
Figure 27: Antibacterial Drug Market, Global, Clinical Trial Duration by Stage of Development and Mechanism of Action (months), 2006-2016
Figure 28: Antibacterial Drug Market, Global, Clinical Trial Size by Stage of Development (participants), 2006-2016
Figure 29: Antibacterial Drug Market, Global, Clinical Trial Size by Stage of Development and Indication (participants), 2006-2016
Figure 30: Antibacterial Drug Market, Global, Clinical Trial Size by Stage of Development and Molecule Type (participants), 2006-2016
Figure 31: Antibacterial Drug Market, Global, Clinical Trial Size by Stage of Development and Mechanism of Action (participants), 2006-2016
Figure 32: Antibacterial Drug Market, Global, Aggregate Clinical Program Size by Stage of Development (participants), 2006-2016
Figure 33: Antibacterial Drug Market, Global, Aggregate Clinical Program Size by Stage of Development and Indication (participants), 2006-2016
Figure 34: Antibacterial Drug Market, Global, Aggregate Clinical Program Size by Stage of Development and Molecule Type (participants), 2006-2016
Figure 35: Antibacterial Drug Market, Global, Aggregate Clinical Program Size by Stage of Development and Mechansim of Action(participants), 2006-2016
Figure 36: Antibacterial Drug Market, Global, Revenue Forecast for Solithera ($m), 2017-2022
Figure 37: Antibacterial Drug Market, Global, Revenue Forecast for Arikace ($m), 2018-2022
Figure 38: Antibacterial Drug Market, Global, Revenue Forecast for Cadazolid ($m), 2017-2022
Figure 39: Antibacterial Drugs Market, Global, Revenue Forecast for Plazomicin ($m), 2018-2022
Figure 40: Antibacterial Drug Market, Global, Revenue Forecast for V114 ($m), 2019-2022
Figure 41: Antibacterial Drugs Market, Global, Revenue Forecast for MEDI4893 ($m), 2019-2022
Figure 42: Antibacterial Drugs Market, Global, Revenue Forecast for Pf-06290510 ($m), 2018-2022
Figure 43: Antibacterial Drugs Market, Global, Revenue Forecast for Pf-06425090 ($m), 2018-2022
Figure 44: Antibacterial Drug Market, Global, Market Size ($bn), 2015-2022
Figure 45: Antibacterial Drug Market, Global, Annual Revenue by Premium and Generic Products ($bn), 2015-2022
Figure 46: Antibacterial Drug Market, Global, Annual Revenue Forecast for Drugs That Modify the Immune Response ($bn), 2015-2022
Figure 47: Antibacterial Drug Market, Global, Annual Revenue Forecast for Bacterial Cell Wall Disruptors/Inhibitors ($bn), 2015-2022
Figure 48: Antibacterial Drug Market, Global, Annual Revenue Forecast for Protein Synthesis Inhibitors ($bn), 2015-2022
Figure 49: Antibacterial Drug Market, Global, Annual Revenue Forecast for DNA Inhibitors ($bn), 2015-2022
Figure 50: Antibacterial Drug Market, Global, Annual Revenue Forecast for Drugs With Multiple Mechanisms of Action ($bn), 2015-2022
Figure 51: Antibacterial Drug Market, Global, Cluster by Growth and Market Share, 2015-2022
Figure 52: Antibacterial Drug Market, Global, Company Analysis Matrix, 2016
Figure 53: Antibacterial Drug Market, Global, Forecast Market Share by Company (%), 2015-2022
Figure 54: Antibacterial Drugs Market, Global, Companies by Compound Annual Growth Rate (%), 2015-2022
Figure 55: Antibacterial Drug Market, Global, Revenues by Product Type, 2015-2022
Figure 56: Antibacterial Drug Market, Global, Pfizer Annual Revenue Forecast, 2015-2022
Figure 57: Antibacterial Drug Market, Global, GlaxoSmithKline Annual Revenue Forecast, 2015-2022
Figure 58: Antibacterial Drug Market, Global, Merck & Co Annual Revenue Forecast, 2015-2022
Figure 59: Antibacterial Drug Market, Global, Allergan Annual Revenue Forecast, 2015-2022
Figure 60: Antibacterial Drug Market, Global, Cempra Annual Revenue Forecast, 2015-2022
Figure 61: Antibacterial Drug Market, Global, Insmed Annual Revenue Forecast, 2015-2022
Figure 62: Antibacterial Drug Market, Global, Otsuka Annual Revenue Forecast, 2015-2022
Figure 63: Antibacterial Drug Market, Global, Roche Annual Revenue Forecast, 2015-2022
Figure 64: Antibacterial Drug Market, Global, Bayer Annual Revenue Forecast, 2015-2022
Figure 65: Antibacterial Drug Market, Global, AstraZeneca Annual Revenue Forecast, 2015-2022
Figure 66: Antibacterial Drug Market, Global, Companies by Type, 2016
Figure 67: Antibacterial Drug Market, Global, Pipeline, Overall, High-Activity and Late-Stage Developers by Level of Specialization, 2016
Figure 68: Antibacterial Drug Market, Global, Proportion of Total Company Revenue Attributed to Antibacterial Disease, 2015-2022
Figure 69: Antibacterial Drugs Market, Global, Licensing Deals by Region, Value and Year, 2006-2016
Figure 70: Antibacterial Drug Market, Global, Licensing Deals by Indication, 2006-2016
Figure 71: Antibacterial Drug Market, Global, Licensing Deals by Stage of Development and Value, 2006-2016
Figure 72: Antibacterial Drug Market, Global, Licensing Deals by Molecule Type, Mechanism of Action and Aggregate Deal Value, 2006-2016
Figure 73: Antibacterial Drug Market, Global, Co-development Deals by Region, Value and Year, 2006-2016
Figure 74: Antibacterial Drug Market, Global, Co-development Deals by Indication and Value, 2006-2016
Figure 75: Antibacterial Drug Market, Global, Co-development Deals by Stage of Development and Value, 2006-2016
Figure 76: Antibacterial Drug Market, Global, Co-development Deals by Molecule Type, Mechanism of Action and Aggregate Deal Value, 2006-2016

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  • Allergan
  • AstraZeneca
  • Bayer
  • Cempra
  • GlaxoSmithKline
  • Insmed
  • Merck & Co
  • Otsuka
  • Pfizer
  • Roche
Note: Product cover images may vary from those shown
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