Classical Methods in Structure Elucidation of Natural Products

  • ID: 4085907
  • Book
  • 280 Pages
  • John Wiley and Sons Ltd
1 of 4
Organic chemistry as we know it today originated from a preoccupation with substances isolated from nature. In the period from 1860 to 1960, the main task was to elucidate their molecular structure by way of degradation and synthesis. In light of the limited experimental methods available and the lack of established reference compounds, this represented an unparalleled intellectual challenge.

This book makes use of twenty–five representative examples to retrace the great accomplishments made by the generation of chemists during this era. At the same time, it questions the reliability of the experimental results when judged by today′s criteria, particularly since the structures for numerous natural products are stated as established facts in standard text books.

With each chapter devoted to one organic compound, the author combines results from historic experiments to trace a line of evidence that may follow the path put forward by the original contributors. However, in some cases the experimental facts have been combined to form another, hopefully shorter, line of evidence. As a result, readers are able to determine for themselves the ′facts behind the established structure assignments′ of a number of important natural products.

Note: Product cover images may vary from those shown
2 of 4
COMPOUNDS WITH ONLY OXYGEN FUNCTIONALITIES

Ascorbic Acid

Hinokitiol

Ascorbic Acid

Hinokitiol

Cantharidine

Camphor

Alpha––Terpineol

Lactaroviolin

Santonine

Estrone

Alpha––Tocopherol

COMPOUNDS WITH NITROGEN AND OXYGEN FUNCTIONALITIES

Pyridoxine

Muscarine

Lupinine

Lysergic Acid

Riboflavine

Cocaine

Quinine

Colchicine

Luciferin

Strychnine

COMPOUNDS WITH ADDITIONAL FUNCTIONALITIES

Biotin

Thiamine

Griseofulvin

COMPOUNDS WITHOUT HETEROATOM–FUNCTIONALITIES

Decacyclene

Carotene

CAN YOU DO IT YOURSELF?

Penicillin
Note: Product cover images may vary from those shown
3 of 4

Loading
LOADING...

4 of 4
Reinhard W. Hoffmann is Professor Emeriti of the University of Marburg. He studied chemistry at the Universität Bonn and received his Dr. rer. nat. in 1958 under the direction of Prof. B. Helferich. He spent two years as postdoctoral fellow at The Pennsylvania State University with Prof. G. W. Brindley and moved then to the Universität Heidelberg for another postdoctoral year with Prof. G. Wittig. In 1964 he obtained his habilitation and in 1967 he moved as lecturer to the Technische Hochschule Darmstadt and in 1970 to his present position as Professor of Organic Chemistry at the Universität Marburg. His research interests are new methods in stereoselective C–C–bond formation, their application in natural products synthesis and the stereochemistry of reactive organometallic compounds. More recent research activities concern combinatorial approaches to new catalysts and conformation design.

Note: Product cover images may vary from those shown
5 of 4
Note: Product cover images may vary from those shown
Adroll
adroll